MRS2500 [2-iodo-N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate], a potent, selective, and stable antagonist of the platelet P2Y1 receptor with strong antithrombotic activity in mice
about
G-protein-coupled receptors signaling pathways in new antiplatelet drug developmentIn silico Approach for Anti-Thrombosis Drug Discovery: P2Y1R Structure-Based TCMs ScreeningPar4 is required for platelet thrombus propagation but not fibrin generation in a mouse model of thrombosis.Characterization of purinergic P2X4 receptor channels expressed in anterior pituitary cellsActivation of distinct P2Y receptor subtypes stimulates insulin secretion in MIN6 mouse pancreatic beta cells.Pharmacochemistry of the platelet purinergic receptors.Functionalized congener approach to the design of ligands for G protein-coupled receptors (GPCRs).Functionalized congeners of P2Y1 receptor antagonists: 2-alkynyl (N)-methanocarba 2'-deoxyadenosine 3',5'-bisphosphate analogues and conjugation to a polyamidoamine (PAMAM) dendrimer carrier.P2Y nucleotide receptors: promise of therapeutic applicationsTwo disparate ligand-binding sites in the human P2Y1 receptor.Ser352 and Ser354 in the carboxyl terminus of the human P2Y(1) receptor are required for agonist-promoted phosphorylation and internalization in MDCK cellsIntestinal alkaline phosphatase regulates protective surface microclimate pH in rat duodenum.Development of selective high affinity antagonists, agonists, and radioligands for the P2Y1 receptor.Agonists and antagonists for P2 receptors.Activation and regulation of purinergic P2X receptor channelsCharacterization of a novel function-blocking antibody targeted against the platelet P2Y1 receptor.P2Y receptors in the mammalian nervous system: pharmacology, ligands and therapeutic potential.Anti-platelet therapy: ADP receptor antagonists.The impact of commercially available purinergic ligands on purinergic signalling research.Purinergic signaling pathways in endocrine system(N)-methanocarba-2MeSADP (MRS2365) is a subtype-specific agonist that induces rapid desensitization of the P2Y1 receptor of human platelets.Virtual screening leads to the discovery of novel non-nucleotide P2Y₁ receptor antagonists.P2Y1 Receptor Activation of the TRPV4 Ion Channel Enhances Purinergic Signaling in Satellite Glial Cells.P2Y Receptors Sensitize Mouse and Human Colonic Nociceptors.Caged agonist of P2Y1 and P2Y12 receptors for light-directed facilitation of platelet aggregation.Action of nucleosides and nucleotides at 7 transmembrane-spanning receptors.Platelet P2 receptors: old and new targets for antithrombotic drugs.Predominant role of spinal P2Y1 receptors in the development of neuropathic pain in rats.Synthesis of enantiomerically pure (S)-methanocarbaribo uracil nucleoside derivatives for use as antiviral agents and P2Y receptor ligands.The Molecular Mechanism of P2Y1 Receptor ActivationDiscovery of Potential Orthosteric and Allosteric Antagonists of P2Y1R from Chinese Herbs by Molecular Simulation Methods.Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli.Stimulation of the P2Y1 receptor up-regulates nucleoside-triphosphate diphosphohydrolase-1 in human retinal pigment epithelial cells.P2 receptors and platelet function.A novel enteric neuron-glia coculture system reveals the role of glia in neuronal development.Antagonism of P2Y1-induced vasorelaxation by acyl CoA: a critical role for palmitate and 3'-phosphate.Gi- and Gq-coupled ADP (P2Y) receptors act in opposition to modulate nociceptive signaling and inflammatory pain behavior.Calmodulin interacts with the platelet ADP receptor P2Y1Ligand binding to a G protein-coupled receptor captured in a mass spectrometer.Identification of a Different Agonist-Binding Site and Activation Mechanism of the Human P2Y1 Receptor.
P2860
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P2860
MRS2500 [2-iodo-N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate], a potent, selective, and stable antagonist of the platelet P2Y1 receptor with strong antithrombotic activity in mice
description
2005 nî lūn-bûn
@nan
2005 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
MRS2500 [2-iodo-N6-methyl-(N)- ...... ntithrombotic activity in mice
@ast
MRS2500 [2-iodo-N6-methyl-(N)- ...... ntithrombotic activity in mice
@en
type
label
MRS2500 [2-iodo-N6-methyl-(N)- ...... ntithrombotic activity in mice
@ast
MRS2500 [2-iodo-N6-methyl-(N)- ...... ntithrombotic activity in mice
@en
prefLabel
MRS2500 [2-iodo-N6-methyl-(N)- ...... ntithrombotic activity in mice
@ast
MRS2500 [2-iodo-N6-methyl-(N)- ...... ntithrombotic activity in mice
@en
P2093
P2860
P50
P356
P1476
MRS2500 [2-iodo-N6-methyl-(N)- ...... ntithrombotic activity in mice
@en
P2093
Béatrice Hechler
Christelle Nonne
Christian Gachet
Eun Joo Roh
François Lanza
P2860
P304
P356
10.1124/JPET.105.094037
P407
P577
2005-10-19T00:00:00Z