t(8;21)(q22;q22) Fusion proteins preferentially bind to duplicated AML1/RUNX1 DNA-binding sequences to differentially regulate gene expression.
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A stable transcription factor complex nucleated by oligomeric AML1–ETO controls leukaemogenesisRunx1 binds as a dimeric complex to overlapping Runx1 sites within a palindromic element in the human GM-CSF enhancerAML1/ETO oncoprotein is directed to AML1 binding regions and co-localizes with AML1 and HEB on its targets.Cbfb/Runx1 repression-independent blockage of differentiation and accumulation of Csf2rb-expressing cells by Cbfb-MYH11.RUNX1 repression-independent mechanisms of leukemogenesis by fusion genes CBFB-MYH11 and AML1-ETO (RUNX1-RUNX1T1).Attenuation of AML1-ETO cellular dysregulation correlates with increased leukemogenic potential.MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome.The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation.PRMT1 interacts with AML1-ETO to promote its transcriptional activation and progenitor cell proliferative potentialRUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis.RUNX1/AML1 DNA-binding domain and ETO/MTG8 NHR2-dimerization domain are critical to AML1-ETO9a leukemogenesis.Core binding factor at the crossroads: determining the fate of the HSC.New insights into transcriptional and leukemogenic mechanisms of AML1-ETO and E2A fusion proteins.RUNX1: A microRNA hub in normal and malignant hematopoiesis.Runx1 Structure and Function in Blood Cell Development.The impact of TEL-AML1 (ETV6-RUNX1) expression in precursor B cells and implications for leukaemia using three different genome-wide screening methods.AML1-ETO targets and suppresses cathepsin G, a serine protease, which is able to degrade AML1-ETO in t(8;21) acute myeloid leukemia.Acute myeloid leukemia with the t(8;21) translocation: clinical consequences and biological implications.Heterodimerization of AML1/ETO with CBFβ is required for leukemogenesis but not for myeloproliferation.RUNX1 and CBFβ Mutations and Activities of Their Wild-Type Alleles in AML.RUNX1-ETO Leukemia.The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation
P2860
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P2860
t(8;21)(q22;q22) Fusion proteins preferentially bind to duplicated AML1/RUNX1 DNA-binding sequences to differentially regulate gene expression.
description
2008 nî lūn-bûn
@nan
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
t
@nl
t(8;21)(q22;q22) Fusion protei ...... ally regulate gene expression.
@ast
t(8;21)(q22;q22) Fusion protei ...... ally regulate gene expression.
@en
type
label
t
@nl
t(8;21)(q22;q22) Fusion protei ...... ally regulate gene expression.
@ast
t(8;21)(q22;q22) Fusion protei ...... ally regulate gene expression.
@en
prefLabel
t
@nl
t(8;21)(q22;q22) Fusion protei ...... ally regulate gene expression.
@ast
t(8;21)(q22;q22) Fusion protei ...... ally regulate gene expression.
@en
P2093
P2860
P1433
P1476
t(8;21)(q22;q22) Fusion protei ...... ally regulate gene expression.
@en
P2093
Akiko J Okumura
Anita Boyapati
Dong-Er Zhang
Fumihiko Okumura
Luke F Peterson
P2860
P304
P356
10.1182/BLOOD-2007-11-124735
P407
P577
2008-05-29T00:00:00Z