about
Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activationTargeting the apoptosis pathway in hematologic malignanciesThermodynamic, enzymatic and structural effects of removing a salt bridge at the base of loop 4 in (pro)caspase-3.A designed redox-controlled caspaseStructural and Enzymatic Insights into Caspase-2 Protein Substrate Recognition and CatalysisAutoactivation of Thrombin PrecursorsFree Glycine Accelerates the Autoproteolytic Activation of Human AsparaginaseStructural snapshots reveal distinct mechanisms of procaspase-3 and -7 activationAllosteric modulation of caspase 3 through mutagenesisTailoring small molecules for an allosteric site on procaspase-6Dual small-molecule targeting of procaspase-3 dramatically enhances zymogen activation and anticancer activityReversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathwaysDiscovery of novel allosteric effectors based on the predicted allosteric sites for Escherichia coli D-3-phosphoglycerate dehydrogenaseFirst- and second-shell metal binding residues in human proteins are disproportionately associated with disease-related SNPs.Docking Screens for Novel Ligands Conferring New Biology.Binding of a small molecule at a protein-protein interface regulates the chaperone activity of hsp70-hsp40.Potent and selective inhibition of the open-channel conformation of AMPA receptors by an RNA aptamer.Allosteric regulation of protease activity by small molecules.Targeted rescue of cancer-associated IDH1 mutant activity using an engineered synthetic antibody.The potential for caspases in drug discoveryA bifunctional allosteric site in the dimer interface of procaspase-3Parallel synthesis and biological evaluation of 837 analogues of procaspase-activating compound 1 (PAC-1)Self-assembling small molecules form nanofibrils that bind procaspase-3 to promote activationUnraveling the mechanism of cell death induced by chemical fibrils.Small molecule screen reveals regulation of survival motor neuron protein abundance by Ras proteins.Structural basis of a point mutation that causes the genetic disease aspartylglucosaminuria.Small-molecule procaspase activators identified using fluorescence polarization.Caspases come together over LPS.Turning on caspases with genetics and small moleculesAllostery in trypsin-like proteases suggests new therapeutic strategies.Removal of Metabolic Liabilities Enables Development of Derivatives of Procaspase-Activating Compound 1 (PAC-1) with Improved PharmacokineticsDerivatives of Procaspase-Activating Compound 1 (PAC-1) and their Anticancer Activities.Differential effects of procaspase-3 activating compounds in the induction of cancer cell death.Conformational selection in trypsin-like proteases.Fibrils colocalize caspase-3 with procaspase-3 to foster maturation.A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed.Designing small molecules to target cryptic pockets yields both positive and negative allosteric modulators.Substrates of IAP ubiquitin ligases identified with a designed orthogonal E3 ligase, the NEDDylatorInnovation in academic chemical screening: filling the gaps in chemical biologyQuantitative studies of caspase-3 catalyzed αII-spectrin breakdown.
P2860
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P2860
description
2009 nî lūn-bûn
@nan
2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Small-molecule activators of a proenzyme.
@ast
Small-molecule activators of a proenzyme.
@en
Small-molecule activators of a proenzyme.
@nl
type
label
Small-molecule activators of a proenzyme.
@ast
Small-molecule activators of a proenzyme.
@en
Small-molecule activators of a proenzyme.
@nl
prefLabel
Small-molecule activators of a proenzyme.
@ast
Small-molecule activators of a proenzyme.
@en
Small-molecule activators of a proenzyme.
@nl
P2093
P2860
P356
P1433
P1476
Small-molecule activators of a proenzyme.
@en
P2093
Daniel C Gray
James A Wells
Julie A Zorn
P2860
P304
P356
10.1126/SCIENCE.1177585
P407
P577
2009-11-01T00:00:00Z