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Structural insights into the human and avian IMP cyclohydrolase mechanism via crystal structures with the bound XMP inhibitorCrystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolatesA comprehensive and scalable database search system for metaproteomicsStructural insights into the avian AICAR transformylase mechanismStructure of avian AICAR transformylase with a multisubstrate adduct inhibitor beta-DADF identifies the folate binding siteTurning a protein kinase on or off from a single allosteric site via disulfide trapping.Ultrahigh and High Resolution Structures and Mutational Analysis of Monomeric Streptococcus pyogenes SpeB Reveal a Functional Role for the Glycine-rich C-terminal LoopSelective detection of caspase-3 versus caspase-7 using activity-based probes with key unnatural amino acidsSelective inhibition of initiator versus executioner caspases using small peptides containing unnatural amino acidsIdentification and Co-complex Structure of a New S. pyogenes SpeB Small Molecule InhibitorSynthesis and Sulfur Electrophilicity of theNupharThiaspirane PharmacophoreProteome-wide covalent ligand discovery in native biological systemsQuantitative Metaproteomics and Activity-Based Probe Enrichment Reveals Significant Alterations in Protein Expression from a Mouse Model of Inflammatory Bowel Disease.Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identify novel nonfolate inhibitors.Data Streaming for Metabolomics: Accelerating Data Processing and Analysis from Days to Minutes.Small-molecule activators of a proenzyme.Self-assembling small molecules form nanofibrils that bind procaspase-3 to promote activationSmall-molecule procaspase activators identified using fluorescence polarization.Fibrils colocalize caspase-3 with procaspase-3 to foster maturation.Acetone-Linked Peptides: A Convergent Approach for Peptide Macrocyclization and Labeling.Molecules that modulate Apaf-1 activity.Substrate Profiling and High Resolution Co-complex Crystal Structure of a Secreted C11 Protease Conserved across Commensal Bacteria.Selective detection and inhibition of active caspase-3 in cells with optimized peptides.Structure-based optimization and synthesis of antiviral drug Arbidol analogues with significantly improved affinity to influenza hemagglutinin.Inducible nitric oxide synthase: role of the N-terminal beta-hairpin hook and pterin-binding segment in dimerization and tetrahydrobiopterin interaction.Nitrosopurines en route to potently cytotoxic asmarinesDiscovery of a highly selective caspase-3 substrate for imaging live cells.Metaproteomics of colonic microbiota unveils discrete protein functions among colitic mice and control groups.METLIN: A Technology Platform for Identifying Knowns and Unknowns.Domain swapping in inducible nitric-oxide synthase. Electron transfer occurs between flavin and heme groups located on adjacent subunits in the dimer.Lipoprotein Signal Peptidase Inhibitors with Antibiotic Properties Identified through Design of a Robust In Vitro HT Platform.X-ray Structures of Two Bacteroides thetaiotaomicron C11 Proteases in Complex with Peptide-Based InhibitorsComPIL 2.0: An Updated Comprehensive Metaproteomics DatabaseA Commensal Dipeptidyl Aminopeptidase with Specificity for N-Terminal Glycine Degrades Human-Produced Antimicrobial Peptides in VitroTriflic Acid Treatment Enables LC-MS/MS Analysis of Insoluble Bacterial BiomassProbing substrate recognition of bacterial lipoprotein signal peptidase using FRET reportersAnnouncement of 2019 Keystone Symposia Conference: "Microbiome: Chemical Mechanisms and Biological Consequences"Genetic basis for the cooperative bioactivation of plant lignans by Eggerthella lenta and other human gut bacteriaSelective and Rapid Cell-Permeable Inhibitor of Human Caspase-3A glycal-based photoaffinity probe that enriches sialic acid binding proteins
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
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հետազոտող
@hy
name
Dennis W Wolan
@es
Dennis W. Wolan
@en
Dennis W. Wolan
@nl
Dennis W. Wolan
@sl
type
label
Dennis W Wolan
@es
Dennis W. Wolan
@en
Dennis W. Wolan
@nl
Dennis W. Wolan
@sl
altLabel
Dennis Wolan
@en
prefLabel
Dennis W Wolan
@es
Dennis W. Wolan
@en
Dennis W. Wolan
@nl
Dennis W. Wolan
@sl
P108
P106
P1153
6603281444
P21
P31
P496
0000-0001-9879-8353
P569
2000-01-01T00:00:00Z