The murine gene p27Kip1 is haplo-insufficient for tumour suppression. - Wikidata - thesis-toulmin - TriplyDB

The murine gene p27Kip1 is haplo-insufficient for tumour suppression.

The murine gene p27Kip1 is haplo-insufficient for tumour suppression.

http://www.wikidata.org/entity/Q33574523

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Negative regulation of G(1)/S transition by the candidate bladder tumour suppressor gene DBCCR1 p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2 Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development.A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression.Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling Chromosome 14 transfer and functional studies identify a candidate tumor suppressor gene, mirror image polydactyly 1, in nasopharyngeal carcinoma Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors Role of the UBL-UBA protein KPC2 in degradation of p27 at G1 phase of the cell cycle.The tumor spectrum in FHIT-deficient mice Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene Expression of several genes in the human chromosome 3p21.3 homozygous deletion region by an adenovirus vector results in tumor suppressor activities in vitro and in vivo Differential gene expression of p27Kip1 and Rb knockout pituitary tumors associated with altered growth and angiogenesis Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans Regulation of the p27(Kip1) tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation No evidence for involvement of SDHD in neuroblastoma pathogenesis The cyclin dependent kinase inhibitor p27 and its prognostic role in breast cancer.Atm heterozygous deficiency enhances development of mammary carcinomas in p53 heterozygous knockout mice.Deregulation of p27 by oncogenic signaling and its prognostic significance in breast cancer Ultrasensitization: switch-like regulation of cellular signaling by transcriptional induction Cap-Independent Translational Control of Carcinogenesis Mourning Dr. Alfred G. Knudson: the two-hit hypothesis, tumor suppressor genes, and the tuberous sclerosis complex AML1 interconnected pathways of leukemogenesis A possible tumor suppressor role of the KLF5 transcription factor in human breast cancer Identification of oncogenes collaborating with p27Kip1 loss by insertional mutagenesis and high-throughput insertion site analysis.6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27 Mutant B-RAF signaling and cyclin D1 regulate Cks1/S-phase kinase-associated protein 2-mediated degradation of p27Kip1 in human melanoma cells p27(Kip1) induction and inhibition of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cells Cloning and functional expression of a degradation-resistant novel isoform of p27Kip1 Tumor suppressor and hepatocellular carcinoma Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytes Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo Roles for Nkx3.1 in prostate development and cancer Conditional loss of Nkx3.1 in adult mice induces prostatic intraepithelial neoplasia Altered prostatic epithelial proliferation and apoptosis, prostatic development, and serum testosterone in mice lacking cyclin-dependent kinase inhibitors Mouse tumor model for neurofibromatosis type 1 Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions Effect of Xpcl1 activation and p27(Kip1) loss on gene expression in murine lymphoma Animal Models of Chemical Carcinogenesis: Driving Breakthroughs in Cancer Research for 100 Years

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The murine gene p27Kip1 is haplo-insufficient for tumour suppression.

http://www.wikidata.org/entity/Q33574523

description

1998 nî lūn-bûn

@nan

1998 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

1998 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

1998年の論文

@ja

1998年論文

@yue

1998年論文

@zh-hant

1998年論文

@zh-hk

1998年論文

@zh-mo

1998年論文

@zh-tw

1998年论文

@wuu

name

The murine gene p27Kip1 is haplo-insufficient for tumour suppression.

@ast

The murine gene p27Kip1 is haplo-insufficient for tumour suppression.

@en

The murine gene p27Kip1 is haplo-insufficient for tumour suppression.

@nl

type

label

The murine gene p27Kip1 is haplo-insufficient for tumour suppression.

@ast

The murine gene p27Kip1 is haplo-insufficient for tumour suppression.

@en

The murine gene p27Kip1 is haplo-insufficient for tumour suppression.

@nl

prefLabel

The murine gene p27Kip1 is haplo-insufficient for tumour suppression.

@ast

The murine gene p27Kip1 is haplo-insufficient for tumour suppression.

@en

The murine gene p27Kip1 is haplo-insufficient for tumour suppression.

@nl

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The murine gene p27Kip1 is haplo-insufficient for tumour suppression.

@en

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C J Kemp

http://www.w3.org/2001/XMLSchema#string

E Randel

http://www.w3.org/2001/XMLSchema#string

J M Roberts

http://www.w3.org/2001/XMLSchema#string

K E Gurley

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M L Fero

http://www.w3.org/2001/XMLSchema#string

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Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

Mutation and cancer: statistical study of retinoblastoma

A cell cycle regulator potentially involved in genesis of many tumor types

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest

Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas

Effects of an Rb mutation in the mouse

Transgenic mouse model for studying the transcriptional activity of the p53 protein: age- and tissue-dependent changes in radiation-induced activation during embryogenesis.

Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice.

A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice.

Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.

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177-180

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10.1038/24179

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396

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9823898

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5395202

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