The benzenesulfoamide T0901317 [N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide] is a novel retinoic acid receptor-related orphan receptor-alpha/gamma inverse agonist.

The benzenesulfoamide T0901317 [N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide] is a novel retinoic acid receptor-related orphan receptor-alpha/gamma inverse agonist.

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http://www.wikidata.org/entity/Q33613397

Q33613397

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Prospero-related homeobox 1 (Prox1) functions as a novel modulator of retinoic acid-related orphan receptors α- and γ-mediated transactivation Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists Targeting Th17 Cells with Small Molecules and Small Interference RNA Orphan nuclear receptors and the regulation of nutrient metabolism: understanding obesity ROR nuclear receptors: structures, related diseases, and drug discovery The therapeutic potential of RORγ modulators in the treatment of human disease Chronopharmacology: new insights and therapeutic implications Cytochrome P450 20A1 in zebrafish: Cloning, regulation and potential involvement in hyperactivity disorders Structural Basis of Digoxin That Antagonizes ROR t Receptor Activity and Suppresses Th17 Cell Differentiation and Interleukin (IL)-17 Production Benzoxazepines Achieve Potent Suppression of IL-17 Release in Human T-Helper 17 (TH 17) Cells through an Induced-Fit Binding Mode to the Nuclear Receptor RORγ Circadian molecular clock in lung pathophysiology Regulation of Adaptive Immunity in Health and Disease by Cholesterol Metabolism Therapeutic Effect of a Synthetic RORα/γ Agonist in an Animal Model of Autism Adipogenesis and insulin sensitivity in obesity are regulated by retinoid-related orphan receptor gamma Development of a Topical Treatment for Psoriasis Targeting RORγ: From Bench to Skin RORγ directly regulates the circadian expression of clock genes and downstream targets in vivo Macrophage-independent regulation of reverse cholesterol transport by liver X receptors.Identification of an allosteric binding site for RORγt inhibition.Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice Hydrogen/deuterium exchange reveals distinct agonist/partial agonist receptor dynamics within vitamin D receptor/retinoid X receptor heterodimer Fasting-induced FGF21 is repressed by LXR activation via recruitment of an HDAC3 corepressor complex in mice Artemisia scoparia enhances adipocyte development and endocrine function in vitro and enhances insulin action in vivo Regulation of FGF21 expression and secretion by retinoic acid receptor-related orphan receptor alpha.A second class of nuclear receptors for oxysterols: Regulation of RORalpha and RORgamma activity by 24S-hydroxycholesterol (cerebrosterol)Ligand regulation of retinoic acid receptor-related orphan receptors: implications for development of novel therapeutics Genome-wide landscape of liver X receptor chromatin binding and gene regulation in human macrophages.Regulation of expression of citrate synthase by the retinoic acid receptor-related orphan receptor α (RORα)Action of RORs and their ligands in (patho)physiology.REV-ERB and ROR nuclear receptors as drug targets.Identification of SR1078, a synthetic agonist for the orphan nuclear receptors RORα and RORγ.LXR-mediated inhibition of CD4+ T helper cells.Crucial roles of mixed-lineage leukemia 3 and 4 as epigenetic switches of the hepatic circadian clock controlling bile acid homeostasis in mice.Small molecule modifiers of circadian clocks.Small molecule amides as potent ROR-γ selective modulators.Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation Nuclear receptors take center stage in Th17 cell-mediated autoimmunity.Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB.Homozygous staggerer (sg/sg) mice display improved insulin sensitivity and enhanced glucose uptake in skeletal muscle Identification of SR3335 (ML-176): a synthetic RORα selective inverse agonist The identification of naturally occurring neoruscogenin as a bioavailable, potent, and high-affinity agonist of the nuclear receptor RORα (NR1F1).

P2860

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P2860

The benzenesulfoamide T0901317 [N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide] is a novel retinoic acid receptor-related orphan receptor-alpha/gamma inverse agonist.

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http://www.wikidata.org/entity/Q33613397

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2009 nî lūn-bûn

@nan

2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2009 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年學術文章

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