Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening - Wikidata - thesis-toulmin - TriplyDB

Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening

Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening

http://www.wikidata.org/entity/Q33749260

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Metabolomics annotates ABHD3 as a physiologic regulator of medium-chain phospholipids Global profiling of dynamic protein palmitoylation Chemical probes of endocannabinoid metabolism The pharmacological landscape and therapeutic potential of serine hydrolases The physiology of protein S-acylation Chemical genetic strategy for targeting protein kinases based on covalent complementarity Biochemical and pharmacological characterization of the human lymphocyte antigen B-associated transcript 5 (BAT5/ABHD16A)Multidimensional profiling platforms reveal metabolic dysregulation caused by organophosphorus pesticides The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs Activity-based proteomic and metabolomic approaches for understanding metabolism Ion channel regulation by protein S-acylation.Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors.Identification of palmitoyl protein thioesterase 1 in human THP1 monocytes and macrophages and characterization of unique biochemical activities for this enzyme High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors.ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice.How chemoproteomics can enable drug discovery and development Exploring metabolic pathways and regulation through functional chemoproteomic and metabolomic platforms Chemical proteomics and its impact on the drug discovery process.Decoupled roles for the atypical, bifurcated binding pocket of the ybfF hydrolase.Chemical genetics screening reveals KIAA1363 as a cytokine-lowering target.Acyl protein thioesterase inhibitors as probes of dynamic S-palmitoylation.A new class of rhomboid protease inhibitors discovered by activity-based fluorescence polarization Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors.Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1.A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors.A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity.The metabolic serine hydrolases and their functions in mammalian physiology and disease.Selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival.ThermoMouse: an in vivo model to identify modulators of UCP1 expression in brown adipose tissue.Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors.Mapping proteome-wide interactions of reactive chemicals using chemoproteomic platforms.Competitive activity-based protein profiling identifies aza-β-lactams as a versatile chemotype for serine hydrolase inhibition.Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates.Identification of selective covalent inhibitors of platelet activating factor acetylhydrolase 1B2 from the screening of an oxadiazolone-capped peptoid-azapeptoid hybrid library.Clickable, photoreactive inhibitors to probe the active site microenvironment of fatty acid amide hydrolase().Screen of Non-annotated Small Secreted Proteins of Pseudomonas syringae Reveals a Virulence Factor That Inhibits Tomato Immune Proteases.An activity-based imaging probe for the integral membrane hydrolase KIAA1363.Substrate-Competitive Activity-Based Profiling of Ester Prodrug Activating Enzymes

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P2860

Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening

http://www.wikidata.org/entity/Q33749260

description

2010 nî lūn-bûn

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2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2010 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Superfamily-wide portrait of s ...... brary-versus-library screening

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Superfamily-wide portrait of s ...... brary-versus-library screening

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Superfamily-wide portrait of s ...... brary-versus-library screening

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Superfamily-wide portrait of s ...... brary-versus-library screening

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Superfamily-wide portrait of s ...... brary-versus-library screening

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PNAS.1011663107

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Proceedings of the National Academy of Sciences of the United States of America

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Superfamily-wide portrait of s ...... brary-versus-library screening

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Alexander Adibekian

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Daniel A Bachovchin

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Gabriel M Simon

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Heather Hoover

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Jacqueline L Blankman

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Sherry Niessen

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Tianyang Ji

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Weiwei Li

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P2860

Rivastigmine for Alzheimer's disease

Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness.

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

Activity-based proteomics of enzyme superfamilies: serine hydrolases as a case study

Mechanism of carbamate inactivation of FAAH: implications for the design of covalent inhibitors and in vivo functional probes for enzymes

A role for the protease falcipain 1 in host cell invasion by the human malaria parasite

Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain

Divergent evolution of enzymatic function: mechanistically diverse superfamilies and functionally distinct suprafamilies

Systematic genome-wide screens of gene function

Enzymatic pathways that regulate endocannabinoid signaling in the nervous system

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20941-20946

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scholarly article

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10.1073/PNAS.1011663107

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P433

49

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107

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Benjamin Cravatt III

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2010-11-17T00:00:00Z

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47811962

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21084632

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3000285

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