Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter.
about
Expression of GATA3 in MDA-MB-231 triple-negative breast cancer cells induces a growth inhibitory response to TGFßEndocytosis and Physiology: Insights from Disabled-2 Deficient MiceSwitching Roles of TGF-β in Cancer Development: Implications for Therapeutic Target and Biomarker StudiesBMP9 is a proliferative and survival factor for human hepatocellular carcinoma cellsGenome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populationsDisabled homolog 2 controls macrophage phenotypic polarization and adipose tissue inflammationGene expression pathways of high grade localized prostate cancer.Regulation of ovarian cancer progression by microRNA-187 through targeting Disabled homolog-2.Dynamic regulation of Tgf-B signaling by Tif1γ: a computational approach.Hormonal induction and roles of Disabled-2 in lactation and involution.Identification of ovarian cancer associated genes using an integrated approach in a Boolean framework.miR-93-directed downregulation of DAB2 defines a novel oncogenic pathway in lung cancer.The translational significance of epithelial-mesenchymal transition in head and neck cancer.Differential requirement for Dab2 in the development of embryonic and extra-embryonic tissues.Epithelial-mesenchymal transition in oral squamous cell carcinomaThe cancer stem cell subtype determines immune infiltration of glioblastoma.The regulation of cell-cell adhesion during epithelial-mesenchymal transition, motility and tumor progression.Genes regulated in metastatic osteosarcoma: evaluation by microarray analysis in four human and two mouse cell line systems.The complexities of TGF-β action during mammary and squamous cell carcinogenesis.Targeting the TGFβ signalling pathway in disease.MicroRNA-106b is involved in transforming growth factor β1-induced cell migration by targeting disabled homolog 2 in cervical carcinoma.PPARδ promotes oncogenic redirection of TGF-β1 signaling through the activation of the ABCA1-Cav1 pathway.The Dual Role of TGFβ in Human Cancer: From Tumor Suppression to Cancer MetastasisThe LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation.Metformin inhibits proliferation and migration of glioblastoma cells independently of TGF-β2.Low disabled-2 expression promotes tumor progression and determines poor survival and high recurrence of esophageal squamous cell carcinoma.Role of Smads in TGFβ signaling.Analysis of microRNA-target interactions across diverse cancer types.Cathepsin-B-mediated cleavage of Disabled-2 regulates TGF-β-induced autophagy.TGF-β signaling in liver and gastrointestinal cancersDisabled-2: A modular scaffold protein with multifaceted functions in signaling.Intrinsic TGF-β2-triggered SDF-1-CXCR4 signaling axis is crucial for drug resistance and a slow-cycling state in bone marrow-disseminated tumor cells.Dab2 inhibits the cholesterol-dependent activation of JNK by TGF-βTargeting TGF-β Signaling for Therapeutic Gain.A human monoclonal antibody 264RAD targeting αvβ6 integrin reduces tumour growth and metastasis, and modulates key biomarkers in vivo.Transforming growth factor-β enhances invasion and metastasis in Ras-transfected human malignant epidermal keratinocytes.Casein kinase 2 regulates the mRNA-destabilizing activity of tristetraprolin.Disabled-2; an autophagic and apoptotic switch.Micro ribonucleic acid-93 promotes proliferation and migration of esophageal squamous cell carcinoma by targeting disabled 2Endocytosis and cancer.
P2860
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P2860
Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Epigenetic downregulation of h ...... uppressor to a tumor promoter.
@ast
Epigenetic downregulation of h ...... uppressor to a tumor promoter.
@en
Epigenetic downregulation of h ...... uppressor to a tumor promoter.
@nl
type
label
Epigenetic downregulation of h ...... uppressor to a tumor promoter.
@ast
Epigenetic downregulation of h ...... uppressor to a tumor promoter.
@en
Epigenetic downregulation of h ...... uppressor to a tumor promoter.
@nl
prefLabel
Epigenetic downregulation of h ...... uppressor to a tumor promoter.
@ast
Epigenetic downregulation of h ...... uppressor to a tumor promoter.
@en
Epigenetic downregulation of h ...... uppressor to a tumor promoter.
@nl
P2093
P2860
P50
P356
P1476
Epigenetic downregulation of h ...... suppressor to a tumor promoter
@en
P2093
Adèle Hannigan
Blanca Herrera
Clare Orange
Darren I O'Brien
David C K Chu
Francesca M Buffa
Gabriela Kalna
Jelena Mann
Johanna K Thurlow
Jonathan A Cooper
P2860
P304
P356
10.1172/JCI36125
P407
P50
P577
2010-07-01T00:00:00Z