A mechanism for synergy with combined mTOR and PI3 kinase inhibitors.
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U12, a UDCA derivative, acts as an anti-hepatoma drug lead and inhibits the mTOR/S6K1 and cyclin/CDK complex pathwaysAddition of Everolimus Post VEGFR Inhibition Treatment Failure in Advanced Sarcoma Patients Who Previously Benefited from VEGFR Inhibition: A Case SeriesTemsirolimus with or without megestrol acetate and tamoxifen for endometrial cancer: a gynecologic oncology group study.Targeting the PI3K/mTOR axis, alone and in combination with autophagy blockade, for the treatment of malignant peripheral nerve sheath tumorsAutophagy down regulates pro-inflammatory mediators in BV2 microglial cells and rescues both LPS and alpha-synuclein induced neuronal cell death.Increased drug resistance is associated with reduced glucose levels and an enhanced glycolysis phenotype.CaMKIV-dependent preservation of mTOR expression is required for autophagy during lipopolysaccharide-induced inflammation and acute kidney injury.NVP-BEZ235, a novel dual PI3K/mTOR inhibitor, enhances the radiosensitivity of human glioma stem cells in vitro.Augmenting autophagy to treat acute kidney injury during endotoxemia in mice.Synergistic effects of concurrent blockade of PI3K and MEK pathways in pancreatic cancer preclinical modelsRole of autophagy in the ω-3 long chain polyunsaturated fatty acid-induced death of lung cancer A549 cells.Heat Stress-Induced PI3K/mTORC2-Dependent AKT Signaling Is a Central Mediator of Hepatocellular Carcinoma Survival to Thermal Ablation Induced Heat StressRapamycin has paradoxical effects on S6 phosphorylation in rats with and without seizures.Application and interpretation of current autophagy inhibitors and activators.mTOR inhibitors in urinary bladder cancer.Comparative analysis of Tsc1 and Tsc2 single and double radial glial cell mutants.Inhibition of pan-class I phosphatidyl-inositol-3-kinase by NVP-BKM120 effectively blocks proliferation and induces cell death in diffuse large B-cell lymphoma.Utilization of genomic signatures to identify high-efficacy candidate drugs for chemorefractory endometrial cancers.Threonine-120 phosphorylation regulated by phosphoinositide-3-kinase/Akt and mammalian target of rapamycin pathway signaling limits the antitumor activity of mammalian sterile 20-like kinase 1.Loss of p27 Associated with Risk for Endometrial Carcinoma Arising in the Setting of Obesity.Restoration of klotho gene expression induces apoptosis and autophagy in gastric cancer cells: tumor suppressive role of klotho in gastric cancer.Autophagy inhibition enhances colorectal cancer apoptosis induced by dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235.Combination treatment of RAD001 and BEZ235 exhibits synergistic antitumor activity via down-regulation of p-4E-BP1/Mcl-1 in small cell lung cancer.Modest enhancement of sensory axon regeneration in the sciatic nerve with conditional co-deletion of PTEN and SOCS3 in the dorsal root ganglia of adult mice.
P2860
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P2860
A mechanism for synergy with combined mTOR and PI3 kinase inhibitors.
description
2011 nî lūn-bûn
@nan
2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
A mechanism for synergy with combined mTOR and PI3 kinase inhibitors.
@ast
A mechanism for synergy with combined mTOR and PI3 kinase inhibitors.
@en
A mechanism for synergy with combined mTOR and PI3 kinase inhibitors.
@nl
type
label
A mechanism for synergy with combined mTOR and PI3 kinase inhibitors.
@ast
A mechanism for synergy with combined mTOR and PI3 kinase inhibitors.
@en
A mechanism for synergy with combined mTOR and PI3 kinase inhibitors.
@nl
prefLabel
A mechanism for synergy with combined mTOR and PI3 kinase inhibitors.
@ast
A mechanism for synergy with combined mTOR and PI3 kinase inhibitors.
@en
A mechanism for synergy with combined mTOR and PI3 kinase inhibitors.
@nl
P2860
P1433
P1476
A mechanism for synergy with combined mTOR and PI3 kinase inhibitors.
@en
P2093
P2860
P304
P356
10.1371/JOURNAL.PONE.0026343
P407
P577
2011-10-19T00:00:00Z