about
Chemical Structure-Biological Activity Models for Pharmacophores' 3D-InteractionsMinimal Pharmacophoric Elements and Fragment Hopping, an Approach Directed at Molecular Diversity and Isozyme Selectivity. Design of Selective Neuronal Nitric Oxide Synthase InhibitorsPeptide-Like Molecules (PLMs): A Journey from Peptide Bond Isosteres to Gramicidin S Mimetics and Mitochondrial Targeting Agents.Online chemical modeling environment (OCHEM): web platform for data storage, model development and publishing of chemical informationHow many molecules does it take to tell a story? Case studies, language, and an epistemic view of medicinal chemistry.N-acylpolyamine inhibitors of HDM2 and HDMX binding to p53.New Synthesis, Structure and Analgesic Properties of Methyl 1-R-4-Methyl-2,2-Dioxo-1H-2λ⁶,1-Benzothiazine-3-Carboxylates.Triazole inhibitors of Cryptosporidium parvum inosine 5'-monophosphate dehydrogenaseDiscovery of benzamide analogues as a novel class of 5-HT₃ receptor agonists.Imaging molecular transport across lipid bilayersBis(4-amino-pyridinium) dichromate(VI).Discovery and synthesis of hydronaphthoquinones as novel proteasome inhibitors.Exploration of 3-Aminoazetidines as Triple Reuptake Inhibitors by Bioisosteric Modification of 3-α-OxyazetidineEffects of endostatin and a new drug terpestacin against human neuroblastoma xenograft and cell lines.Bis(2,6-diamino-pyridin-1-ium) hexa-aqua-cobalt(II) disulfate dihydrateAnthracene-based inhibitors of dengue virus NS2B-NS3 proteasePantothenamides are potent, on-target inhibitors of Plasmodium falciparum growth when serum pantetheinase is inactivatedOptimization of the anti-cancer activity of phosphatidylinositol-3 kinase pathway inhibitor PITENIN-1: switching a thiourea with 1,2,3-triazoleSynthesis and biological evaluation of carbocyclic analogues of pachastrissamine.Probing myo-inositol 1-phosphate synthase with multisubstrate adducts.Efficient discovery of responses of proteins to compounds using active learningModeling biophysical and biological properties from the characteristics of the molecular electron density, electron localization and delocalization matrices, and the electrostatic potential.Imidazolines as non-classical bioisosteres of N-acyl homoserine lactones and quorum sensing inhibitors.Identification of Leishmania donovani Topoisomerase 1 inhibitors via intuitive scaffold hopping and bioisosteric modification of known Top 1 inhibitorsDeciphering the Structural Requirements of Nucleoside Bisubstrate Analogues for Inhibition of MbtA in Mycobacterium tuberculosis: A FB-QSAR Study and Combinatorial Library Generation for Identifying Potential Hits.Comparison of carbon-sulfur and carbon-amine bond in therapeutic drug: 4β-S-aromatic heterocyclic podophyllum derivatives display antitumor activity.Development of Chlamydial Type III Secretion System Inhibitors for Suppression of Acute and Chronic Forms of Chlamydial InfectionDesign, Synthesis, and Identification of Silicon Incorporated Oxazolidinone Antibiotics with Improved Brain Exposure.Fluoride-containing podophyllum derivatives exhibit antitumor activities through enhancing mitochondrial apoptosis pathway by increasing the expression of caspase-9 in HeLa cells.When Medicine Meets Engineering-Paradigm Shifts in Diagnostics and TherapeuticsDesign, Synthesis, and Evaluation of Irciniastatin Analogues: Simplification of the Tetrahydropyran Core and the C(11) Substituents.Structure Property Relationships of Carboxylic Acid Isosteres.Carboxylic acid (bio)isosteres in drug design.Pyrazolo[1,5-a]-1,3,5-triazine as a purine bioisostere: access to potent cyclin-dependent kinase inhibitor (R)-roscovitine analogue.Simple di- and trivanillates exhibit cytostatic properties toward cancer cells resistant to pro-apoptotic stimuli.Synthesis of alkenyldiarylmethanes (ADAMs) containing benzo[d]isoxazole and oxazolidin-2-one rings, a new series of potent non-nucleoside HIV-1 reverse transcriptase inhibitors.Synthesis of 2-oxoamides based on sulfonamide analogs of gamma-amino acids and their activity on phospholipase A2.Design and synthesis of novel antimicrobials with activity against Gram-positive bacteria and mycobacterial species, including M. tuberculosis.Graph-based similarity concepts in virtual screening.Novel HIV-1 non-nucleoside reverse transcriptase inhibitors: a patent review (2005 - 2010).
P2860
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P2860
description
1996 nî lūn-bûn
@nan
1996 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Bioisosterism: A Rational Approach in Drug Design.
@ast
Bioisosterism: A Rational Approach in Drug Design.
@en
Bioisosterism: A Rational Approach in Drug Design.
@nl
type
label
Bioisosterism: A Rational Approach in Drug Design.
@ast
Bioisosterism: A Rational Approach in Drug Design.
@en
Bioisosterism: A Rational Approach in Drug Design.
@nl
prefLabel
Bioisosterism: A Rational Approach in Drug Design.
@ast
Bioisosterism: A Rational Approach in Drug Design.
@en
Bioisosterism: A Rational Approach in Drug Design.
@nl
P356
P1433
P1476
Bioisosterism: A Rational Approach in Drug Design.
@en
P2093
Edmond J. LaVoie
George A. Patani
P304
P356
10.1021/CR950066Q
P577
1996-12-01T00:00:00Z