Pantothenamides are potent, on-target inhibitors of Plasmodium falciparum growth when serum pantetheinase is inactivated
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Genetic Characterization of Plasmodium Putative Pantothenate Kinase Genes Reveals Their Essential Role in Malaria Parasite Transmission to the MosquitoStage-Specific Changes in Plasmodium Metabolism Required for Differentiation and Adaptation to Different Host and Vector EnvironmentsMolecular Mechanisms for Drug Hypersensitivity Induced by the Malaria Parasite's Chloroquine Resistance TransporterBiological characterization of chemically diverse compounds targeting the Plasmodium falciparum coenzyme A synthesis pathwayThe Malaria Parasite's Lactate Transporter PfFNT Is the Target of Antiplasmodial Compounds Identified in Whole Cell Phenotypic ScreensDiverse chemotypes disrupt ion homeostasis in the Malaria parasite.Structural modification of pantothenamides counteracts degradation by pantetheinase and improves antiplasmodial activityGenetic Characterization of Coenzyme A Biosynthesis Reveals Essential Distinctive Functions during Malaria Parasite Development in Blood and Mosquito.A novel approach for the discovery of chemically diverse anti-malarial compounds targeting the Plasmodium falciparum Coenzyme A synthesis pathway.Exploring structural motifs necessary for substrate binding in the active site of Escherichia coli pantothenate kinase.A pantetheinase-resistant pantothenamide with potent, on-target, and selective antiplasmodial activityA cross-metathesis approach to novel pantothenamide derivatives.Triazole Substitution of a Labile Amide Bond Stabilizes Pantothenamides and Improves Their Antiplasmodial Potency.Stereochemical modification of geminal dialkyl substituents on pantothenamides alters antimicrobial activityChemical biology tools to study pantetheinases of the vanin family.Recent advances in targeting coenzyme A biosynthesis and utilization for antimicrobial drug development.Exploiting the coenzyme A biosynthesis pathway for the identification of new antimalarial agents: the case for pantothenamides.Novel pantothenate derivatives for anti-malarial chemotherapy.Acetyl-4'-phosphopantetheine is stable in serum and prevents phenotypes induced by pantothenate kinase deficiency.Combination of pantothenamides with vanin inhibitors as a novel antibiotic strategy against gram-positive bacteria.Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues.Variation in pantothenate kinase type determines the pantothenamide mode of action and impacts on coenzyme A salvage biosynthesis.Diverse antimalarials from whole-cell phenotypic screens disrupt malaria parasite ion and volume homeostasis.Biochemical characterization and chemical inhibition of PfATP4-associated Na-ATPase activity in membranesCell Swelling Induced by the Antimalarial KAE609 (Cipargamin) and Other PfATP4-Associated Antimalarials
P2860
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P2860
Pantothenamides are potent, on-target inhibitors of Plasmodium falciparum growth when serum pantetheinase is inactivated
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2013 nî lūn-bûn
@nan
2013 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2013年の論文
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2013年論文
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2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Pantothenamides are potent, on ...... m pantetheinase is inactivated
@ast
Pantothenamides are potent, on ...... m pantetheinase is inactivated
@en
Pantothenamides are potent, on ...... m pantetheinase is inactivated
@nl
type
label
Pantothenamides are potent, on ...... m pantetheinase is inactivated
@ast
Pantothenamides are potent, on ...... m pantetheinase is inactivated
@en
Pantothenamides are potent, on ...... m pantetheinase is inactivated
@nl
prefLabel
Pantothenamides are potent, on ...... m pantetheinase is inactivated
@ast
Pantothenamides are potent, on ...... m pantetheinase is inactivated
@en
Pantothenamides are potent, on ...... m pantetheinase is inactivated
@nl
P2093
P2860
P50
P1433
P1476
Pantothenamides are potent, on ...... m pantetheinase is inactivated
@en
P2093
Cristiano Macuamule
Kristopher G Virga
Zhiyang Lin
P2860
P304
P356
10.1371/JOURNAL.PONE.0054974
P407
P577
2013-02-06T00:00:00Z