Chronic exposure of HIT cells to high glucose concentrations paradoxically decreases insulin gene transcription and alters binding of insulin gene regulatory protein.
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Concise review: in search of unlimited sources of functional human pancreatic beta cellsThe role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells.An islet in distress: β cell failure in type 2 diabetes.Multiple chromatin-bound protein kinases assemble factors that regulate insulin gene transcription.The activation of the rat insulin gene II by BETA2 and PDX-1 in rat insulinoma cells is repressed by Pax6The relationship between fasting hyperglycemia and insulin secretion in subjects with normal or impaired glucose toleranceDown-regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype 5: a novel mechanism for inhibition of cellular proliferation and insulin secretion by somatostatin.Reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expressionRegulation of MafA expression in pancreatic beta-cells in db/db mice with diabetes.A role for glutathione peroxidase in protecting pancreatic beta cells against oxidative stress in a model of glucose toxicity.High glucose predisposes gene expression and ERK phosphorylation to apoptosis and impaired glucose-stimulated insulin secretion via the cytoskeletonGlucolipotoxicity in Pancreatic β-Cells.Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants.Endoplasmic reticulum stress and insulin biosynthesis: a reviewTranscriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxesGlucose induces MafA expression in pancreatic beta cell lines via the hexosamine biosynthetic pathway.The Effects of Empagliflozin, an SGLT2 Inhibitor, on Pancreatic β-Cell Mass and Glucose Homeostasis in Type 1 DiabetesNegative regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype 5.Inhibition of Small Maf Function in Pancreatic β-Cells Improves Glucose Tolerance Through the Enhancement of Insulin Gene Transcription and Insulin Secretion.The ethyl acetate fraction of corn silk exhibits dual antioxidant and anti-glycation activities and protects insulin-secreting cells from glucotoxicity.Short-term regulation of insulin gene transcription by glucose.Sustained expression of the transcription factor GLIS3 is required for normal beta cell function in adults.Glucolipotoxicity: fuel excess and beta-cell dysfunction.Ebselen treatment prevents islet apoptosis, maintains intranuclear Pdx-1 and MafA levels, and preserves β-cell mass and function in ZDF ratsBeta-cell failure as a complication of diabetes.Chronic exposure of betaTC-6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator.Effects of tacrolimus (FK506) on human insulin gene expression, insulin mRNA levels, and insulin secretion in HIT-T15 cells.Differentiation of glucose toxicity from beta cell exhaustion during the evolution of defective insulin gene expression in the pancreatic islet cell line, HIT-T15Adaptation and failure of pancreatic beta cells in murine models with different degrees of metabolic syndromeDiscovery, Synthesis, and Evaluation of 2,4-Diaminoquinazolines as a Novel Class of Pancreatic β-Cell-Protective Agents against Endoplasmic Reticulum (ER) Stress.Beta-cell deterioration during diabetes: what's in the gun?Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes.Targeting orphan nuclear receptor SHP in the treatment of metabolic diseases.Systemic effects of white adipose tissue dysregulation and obesity-related inflammation.Oxidative stress and diabetes mellitus.Beta cell function: the role of macrophage migration inhibitory factor.Involvement of oxidative stress in suppression of insulin biosynthesis under diabetic conditions.SGLT2 inhibition: a novel prospective strategy in treatment of diabetes mellitus.Glucose modulates the binding activity of the beta-cell transcription factor IUF1 in a phosphorylation-dependent manner.Suppression of transcription factor PDX-1/IPF1/STF-1/IDX-1 causes no decrease in insulin mRNA in MIN6 cells.
P2860
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P2860
Chronic exposure of HIT cells to high glucose concentrations paradoxically decreases insulin gene transcription and alters binding of insulin gene regulatory protein.
description
1993 nî lūn-bûn
@nan
1993 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Chronic exposure of HIT cells ...... sulin gene regulatory protein.
@ast
Chronic exposure of HIT cells ...... sulin gene regulatory protein.
@en
Chronic exposure of HIT cells ...... sulin gene regulatory protein.
@nl
type
label
Chronic exposure of HIT cells ...... sulin gene regulatory protein.
@ast
Chronic exposure of HIT cells ...... sulin gene regulatory protein.
@en
Chronic exposure of HIT cells ...... sulin gene regulatory protein.
@nl
prefLabel
Chronic exposure of HIT cells ...... sulin gene regulatory protein.
@ast
Chronic exposure of HIT cells ...... sulin gene regulatory protein.
@en
Chronic exposure of HIT cells ...... sulin gene regulatory protein.
@nl
P2093
P2860
P356
P1476
Chronic exposure of HIT cells ...... nsulin gene regulatory protein
@en
P2093
R P Robertson
P2860
P304
P356
10.1172/JCI116596
P407
P577
1993-07-01T00:00:00Z