Cholesterol oxidation in the retina: implications of 7KCh formation in chronic inflammation and age-related macular degeneration
about
Cholesterol-enriched diet causes age-related macular degeneration-like pathology in rabbit retinaLipid biomarkers of oxidative stress in a genetic mouse model of Smith-Lemli-Opitz syndrome7-Dehydrocholesterol-derived oxysterols and retinal degeneration in a rat model of Smith-Lemli-Opitz syndromeAMD and the alternative complement pathway: genetics and functional implicationsRegulation of signaling events involved in the pathophysiology of neovascular AMDThe unfolded protein response in retinal vascular diseases: implications and therapeutic potential beyond protein foldingOxysterols in the pathogenesis of major chronic diseasesMacular xanthophylls, lipoprotein-related genes, and age-related macular degenerationAbnormal vascularization in mouse retina with dysregulated retinal cholesterol homeostasis.Ion-current-based proteomic profiling of the retina in a rat model of Smith-Lemli-Opitz syndrome.Oxysterols and their cellular effectors.Cholesterol in the retina: the best is yet to come.Differential effects of the estrogen receptor agonist estradiol on toxicity induced by enzymatically-derived or autoxidation-derived oxysterols in human ARPE-19 cells.Why AMD is a disease of ageing and not of development: mechanisms and insights.7-Ketocholesterol-induced inflammation signals mostly through the TLR4 receptor both in vitro and in vivo.Sterculic acid antagonizes 7-ketocholesterol-mediated inflammation and inhibits choroidal neovascularization.The ins and outs of cholesterol in the vertebrate retina.Age-related macular degeneration: genetics and biology coming together.7-Ketocholesterol induces inflammation and angiogenesis in vivo: a novel rat model.7-ketocholesterol accumulates in ocular tissues as a consequence of aging and is present in high levels in drusen.Mechanisms of oxysterol-induced carcinogenesis.Conversion of 7-ketocholesterol to oxysterol metabolites by recombinant CYP27A1 and retinal pigment epithelial cells.Inflammasomes Induced by 7-Ketocholesterol and Other Stimuli in RPE and in Bone Marrow-Derived Cells Differ Markedly in Their Production of IL-1β and IL-18.7-Ketocholesterol increases retinal microglial migration, activation, and angiogenicity: a potential pathogenic mechanism underlying age-related macular degenerationExtra-hepatic metabolism of 7-ketocholesterol occurs by esterification to fatty acids via cPLA2α and SOAT1 followed by selective efflux to HDLNovel oxysterols observed in tissues and fluids of AY9944-treated rats: a model for Smith-Lemli-Opitz syndrome.Free radical oxidation of cholesterol and its precursors: Implications in cholesterol biosynthesis disorders.Structural characterization of human cholesterol 7α-hydroxylaseCETP/LPL/LIPC gene polymorphisms and susceptibility to age-related macular degeneration.Complement dysregulation in AMD: RPE-Bruch's membrane-choroidAssays of plasma dehydrocholesteryl esters and oxysterols from Smith-Lemli-Opitz syndrome patientsPosttranslational modification by an isolevuglandin diminishes activity of the mitochondrial cytochrome P450 27A1Aging is not a disease: distinguishing age-related macular degeneration from aging.7-ketocholesterol induces apoptosis of MC3T3-E1 cells associated with reactive oxygen species generation, endoplasmic reticulum stress and caspase-3/7 dependent pathway7-Ketocholesterol induces ATM/ATR, Chk1/Chk2, PI3K/Akt signalings, cytotoxicity and IL-8 production in endothelial cells.Mechanism of inflammation in age-related macular degeneration: an up-to-date on genetic landmarks.Consumption of Red/Processed Meat and Colorectal Carcinoma: Possible Mechanisms Underlying the Significant Association.Plasma lipoprotein subfraction concentrations are associated with lipid metabolism and age-related macular degeneration.Inhibition of endothelial- and neuronal-type, but not inducible-type, nitric oxide synthase by the oxidized cholesterol metabolite secosterol aldehyde: Implications for vascular and neurodegenerative diseases.Differential cytotoxic effects of 7-dehydrocholesterol-derived oxysterols on cultured retina-derived cells: Dependence on sterol structure, cell type, and density.
P2860
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P2860
Cholesterol oxidation in the retina: implications of 7KCh formation in chronic inflammation and age-related macular degeneration
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Cholesterol oxidation in the r ...... e-related macular degeneration
@ast
Cholesterol oxidation in the r ...... e-related macular degeneration
@en
Cholesterol oxidation in the r ...... e-related macular degeneration
@nl
type
label
Cholesterol oxidation in the r ...... e-related macular degeneration
@ast
Cholesterol oxidation in the r ...... e-related macular degeneration
@en
Cholesterol oxidation in the r ...... e-related macular degeneration
@nl
prefLabel
Cholesterol oxidation in the r ...... e-related macular degeneration
@ast
Cholesterol oxidation in the r ...... e-related macular degeneration
@en
Cholesterol oxidation in the r ...... e-related macular degeneration
@nl
P2860
P356
P1476
Cholesterol oxidation in the r ...... e-related macular degeneration
@en
P2093
Ignacio M Larrayoz
Ignacio R Rodríguez
P2860
P304
P356
10.1194/JLR.R004820
P577
2010-06-21T00:00:00Z