The small GTPase Rap1 is required for Mn(2+)- and antibody-induced LFA-1- and VLA-4-mediated cell adhesion.
about
The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1A LAD-III syndrome is associated with defective expression of the Rap-1 activator CalDAG-GEFI in lymphocytes, neutrophils, and plateletsThe small GTPase Rap1b regulates the cross talk between platelet integrin alpha2beta1 and integrin alphaIIbbeta3Ezrin and moesin are required for efficient T cell adhesion and homing to lymphoid organsMultiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functionsGlycosyltransferase-programmed stereosubstitution (GPS) to create HCELL: engineering a roadmap for cell migrationThe LFA-1-associated molecule PTA-1 (CD226) on T cells forms a dynamic molecular complex with protein 4.1G and human discs largeRap1 activation in collagen phagocytosis is dependent on nonmuscle myosin II-A.Direct spatial control of Epac1 by cyclic AMP.SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility.Small molecule agonists of integrin CD11b/CD18 do not induce global conformational changes and are significantly better than activating antibodies in reducing vascular injury.Regulation of the small GTPase Rap1 and extracellular signal-regulated kinases by the costimulatory molecule CTLA-4.CTLA-4 up-regulation of lymphocyte function-associated antigen 1 adhesion and clustering as an alternate basis for coreceptor function.B-Raf regulation of integrin α4β1-mediated resistance to shear stress through changes in cell spreading and cytoskeletal association in T cellsSpatial regulation of cyclic AMP-Epac1 signaling in cell adhesion by ERM proteins.The small GTPase Rap1 is activated by turbulence and is involved in integrin [alpha]IIb[beta]3-mediated cell adhesion in human megakaryocytes.Rapid flow cytometry method for quantitation of LFA-1-adhesive T cellsReceptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression.Glucagon stimulates hepatic FGF21 secretion through a PKA- and EPAC-dependent posttranscriptional mechanism.Acquisition of resistance toward HYD1 correlates with a reduction in cleaved α4 integrin expression and a compromised CAM-DR phenotype.Actin polymerization stabilizes α4β1 integrin anchors that mediate monocyte adhesion.Dysregulation of neutrophil CXCR2 and pulmonary endothelial icam-1 promotes age-related pulmonary inflammation.Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 but not VLA-4 integrin mediated human T-cell adhesionDynamin2 controls Rap1 activation and integrin clustering in human T lymphocyte adhesionCyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptorReduced neutrophil chemotaxis and infiltration contributes to delayed resolution of cutaneous wound infection with advanced age.Novel mutations in RASGRP2, which encodes CalDAG-GEFI, abrogate Rap1 activation, causing platelet dysfunction.EPAC proteins transduce diverse cellular actions of cAMP.The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function.Podocyte-specific RAP1GAP expression contributes to focal segmental glomerulosclerosis-associated glomerular injuryCbl-family proteins as regulators of cytoskeleton-dependent phenomena.Contribution of very late antigen-4 (VLA-4) integrin to cancer progression and metastasis.The ubiquitin C-terminal hydrolase UCH-L1 regulates B-cell proliferation and integrin activation.SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras.Characterization of interactions of adapter protein RAPL/Nore1B with RAP GTPases and their role in T cell migration.Active Rap1, a small GTPase that induces malignant transformation of hematopoietic progenitors, localizes in the nucleus and regulates protein expression.Specific integrin alpha and beta chain phosphorylations regulate LFA-1 activation through affinity-dependent and -independent mechanisms.Protein kinase A-dependent phosphorylation of Lutheran/basal cell adhesion molecule glycoprotein regulates cell adhesion to laminin alpha5.Down-regulation of Rap1 activity is involved in ephrinB1-induced cell contraction.Epac- and Ca2+ -controlled activation of Ras and extracellular signal-regulated kinases by Gs-coupled receptors.
P2860
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P2860
The small GTPase Rap1 is required for Mn(2+)- and antibody-induced LFA-1- and VLA-4-mediated cell adhesion.
description
2002 nî lūn-bûn
@nan
2002 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
The small GTPase Rap1 is required for Mn
@nl
The small GTPase Rap1 is requi ...... VLA-4-mediated cell adhesion.
@ast
The small GTPase Rap1 is requi ...... VLA-4-mediated cell adhesion.
@en
type
label
The small GTPase Rap1 is required for Mn
@nl
The small GTPase Rap1 is requi ...... VLA-4-mediated cell adhesion.
@ast
The small GTPase Rap1 is requi ...... VLA-4-mediated cell adhesion.
@en
prefLabel
The small GTPase Rap1 is required for Mn
@nl
The small GTPase Rap1 is requi ...... VLA-4-mediated cell adhesion.
@ast
The small GTPase Rap1 is requi ...... VLA-4-mediated cell adhesion.
@en
P2093
P2860
P356
P1476
The small GTPase Rap1 is requi ...... VLA-4-mediated cell adhesion.
@en
P2093
Johannes L Bos
Kim M T de Bruyn
Kris A Reedquist
Savithri Rangarajan
P2860
P304
29468-29476
P356
10.1074/JBC.M204990200
P407
P50
P577
2002-05-24T00:00:00Z