Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma. - Wikidata - thesis-toulmin - TriplyDB

Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma.

Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma.

http://www.wikidata.org/entity/Q34171081

about

DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas DLC-1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic development DLC-1: a Rho GTPase-activating protein and tumour suppressor DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity The RhoGAP protein DLC-1 functions as a metastasis suppressor in breast cancer cells DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration Deleted in liver cancer-1 (DLC-1): a tumor suppressor not just for liver Underexpression of deleted in liver cancer 2 (DLC2) is associated with overexpression of RhoA and poor prognosis in hepatocellular carcinoma Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities The liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma Mutationally activated Rho GTPases in cancer Deleted in liver cancer-1 (DLC1): an emerging metastasis suppressor gene Mapping of Mcs30, a new mammary carcinoma susceptibility quantitative trait locus (QTL30) on rat chromosome 12: identification of fry as a candidate Mcs gene Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?Restoration of DLC-1 gene expression induces apoptosis and inhibits both cell growth and tumorigenicity in human hepatocellular carcinoma cells Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin A novel isoform of the 8p22 tumor suppressor gene DLC1 suppresses tumor growth and is frequently silenced in multiple common tumors StarD13 is a tumor suppressor in breast cancer that regulates cell motility and invasion Deleted in liver cancer protein family in human malignancies (Review)DLC1 activation requires lipid interaction through a polybasic region preceding the RhoGAP domain Role of DLC1 tumor suppressor gene and MYC oncogene in pathogenesis of human hepatocellular carcinoma: potential prospects for combined targeted therapeutics (review)Functional cross-talk between ras and rho pathways: a Ras-specific GTPase-activating protein (p120RasGAP) competitively inhibits the RhoGAP activity of deleted in liver cancer (DLC) tumor suppressor by masking the catalytic arginine finger DLC1 is the principal biologically-relevant down-regulated DLC family member in several cancers The somatostatin analogue octreotide inhibits growth of small intestine neuroendocrine tumour cells The tumour suppressor DLC2 ensures mitotic fidelity by coordinating spindle positioning and cell-cell adhesion The NMR structure of the murine DLC2 SAM domain reveals a variant fold that is similar to a four-helix bundle Deleted in liver cancer 2 (DLC2) was dispensable for development and its deficiency did not aggravate hepatocarcinogenesis.Co-regulatory expression quantitative trait loci mapping: method and application to endometrial cancer.Molecular Pathogenesis of Hepatitis-B-virus-associated Hepatocellular Carcinoma.MicroRNA-125b induces metastasis by targeting STARD13 in MCF-7 and MDA-MB-231 breast cancer cells StarD10, a START domain protein overexpressed in breast cancer, functions as a phospholipid transfer protein.The retroviral oncoprotein Tax targets the coiled-coil centrosomal protein TAX1BP2 to induce centrosome overduplication.Metabolomics identifies the intersection of phosphoethanolamine with menaquinone-triggered apoptosis in an in vitro model of leukemia The regulation of RhoA at focal adhesions by StarD13 is important for astrocytoma cell motility.Cytogenetic and molecular genetic alterations in hepatocellular carcinoma.Expression of deleted in liver cancer 2 in colorectal cancer and its correlation with clinicopathological parameters.StARD13(Dlc-2) RhoGap mediates ceramide activation of phosphatidylglycerolphosphate synthase and drug response in Chinese hamster ovary cells.Chronic hepatitis B in hepatocarcinogenesis Current knowledge of the large RhoGAP family of proteins.

P2860

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P2860

Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma.

http://www.wikidata.org/entity/Q34171081

description

2003 nî lūn-bûn

@nan

2003 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2003年の論文

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2003年論文

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2003年論文

@zh-hant

2003年論文

@zh-hk

2003年論文

@zh-mo

2003年論文

@zh-tw

2003年论文

@wuu

name

Deleted in liver cancer (DLC) ...... d in hepatocellular carcinoma.

@ast

Deleted in liver cancer (DLC) ...... d in hepatocellular carcinoma.

@en

Deleted in liver cancer

@nl

type

label

Deleted in liver cancer (DLC) ...... d in hepatocellular carcinoma.

@ast

Deleted in liver cancer (DLC) ...... d in hepatocellular carcinoma.

@en

Deleted in liver cancer

@nl

prefLabel

Deleted in liver cancer (DLC) ...... d in hepatocellular carcinoma.

@ast

Deleted in liver cancer (DLC) ...... d in hepatocellular carcinoma.

@en

Deleted in liver cancer

@nl

P1433

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P2860

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P1433

Journal of Biological Chemistry

P1476

Deleted in liver cancer (DLC) ...... d in hepatocellular carcinoma.

@en

P2093

Chun-Ming Wong

http://www.w3.org/2001/XMLSchema#string

David Chi-Heng Ng

http://www.w3.org/2001/XMLSchema#string

Dong-Yan Jin

http://www.w3.org/2001/XMLSchema#string

Irene Oi-lin Ng

http://www.w3.org/2001/XMLSchema#string

Shing-Fai Chan

http://www.w3.org/2001/XMLSchema#string

Thomas Ho-Yin Leung

http://www.w3.org/2001/XMLSchema#string

Yick-Pang Ching

http://www.w3.org/2001/XMLSchema#string

P2860

PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia

Hepatitis C virus core protein-induced loss of LZIP function correlates with cellular transformation

Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain.

Structure and lipid transport mechanism of a StAR-related domain

Polymerization of the SAM domain of TEL in leukemogenesis and transcriptional repression

The crystal structure of an Eph receptor SAM domain reveals a mechanism for modular dimerization

Genetic instabilities in human cancers

START: a lipid-binding domain in StAR, HD-ZIP and signalling proteins

Mouse peroxiredoxin V is a thioredoxin peroxidase that inhibits p53-induced apoptosis

AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

P304

10824-10830

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P31

scholarly article

P356

10.1074/JBC.M208310200

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P407

P433

12

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P478

278

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P577

2003-01-16T00:00:00Z

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P698

12531887

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