Selective induction of calcineurin activity and signaling by oligomeric amyloid beta - Wikidata - thesis-toulmin - TriplyDB

Selective induction of calcineurin activity and signaling by oligomeric amyloid beta

Selective induction of calcineurin activity and signaling by oligomeric amyloid beta

http://www.wikidata.org/entity/Q34194579

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Protein phosphatases and Alzheimer's disease Calcineurin inhibition at the clinical phase of prion disease reduces neurodegeneration, improves behavioral alterations and increases animal survival Development of a Fluorescent Quenching Based High Throughput Assay to Screen for Calcineurin Inhibitors Alzheimers Disease A central role for calcineurin in protein misfolding neurodegenerative diseases.S100a9 knockdown decreases the memory impairment and the neuropathology in Tg2576 mice, AD animal model.Dysregulated phosphorylation of Ca(2+) /calmodulin-dependent protein kinase II-α in the hippocampus of subjects with mild cognitive impairment and Alzheimer's disease.Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation.Calcium signaling and amyloid toxicity in Alzheimer disease.TNF-α contributes to caspase-3 independent apoptosis in neuroblastoma cells: role of NFAT Amyloid-beta oligomers impair fear conditioned memory in a calcineurin-dependent fashion in mice.Calcineurin and glial signaling: neuroinflammation and beyond Neuroprotective role of γ-enolase in microglia in a mouse model of Alzheimer's disease is regulated by cathepsin X.Proteolysis of calcineurin is increased in human hippocampus during mild cognitive impairment and is stimulated by oligomeric Abeta in primary cell culture.α-Synuclein oligomers oppose long-term potentiation and impair memory through a calcineurin-dependent mechanism: relevance to human synucleopathic diseases.Mechanism of Oxidative Stress and Synapse Dysfunction in the Pathogenesis of Alzheimer's Disease: Understanding the Therapeutics Strategies Reduction in neuronal L-type calcium channel activity in a double knock-in mouse model of Alzheimer's disease.Absence of amyloid β oligomers at the postsynapse and regulated synaptic Zn2+ in cognitively intact aged individuals with Alzheimer's disease neuropathology.Reduced Incidence of Dementia in Solid Organ Transplant Patients Treated with Calcineurin Inhibitors Tau accumulation induces synaptic impairment and memory deficit by calcineurin-mediated inactivation of nuclear CaMKIV/CREB signaling Intermediate- and long-term recognition memory deficits in Tg2576 mice are reversed with acute calcineurin inhibition.Cognitive decline in Alzheimer's disease is associated with selective changes in calcineurin/NFAT signaling.Neuronal calcium signaling, mitochondrial dysfunction, and Alzheimer's disease.Role of calcineurin in neurodegeneration produced by misfolded proteins and endoplasmic reticulum stress.Neuroimmunomodulation by calcineurin in aging and Alzheimer's disease.A role for calcineurin in Alzheimer's disease.The Essential Role of Soluble Aβ Oligomers in Alzheimer's Disease.Regulatory Mechanisms of Endoplasmic Reticulum Resident IP3 Receptors.Multifunctional Effect of Human Serum Albumin Reduces Alzheimer's Disease Related Pathologies in the 3xTg Mouse Model.Dysregulation of neuronal calcium homeostasis in Alzheimer's disease - A therapeutic opportunity?The role of Ca2+ signaling in Parkinson's disease.Calcineurin β protects brain after injury by activating the unfolded protein response.NFATs and Alzheimer's Disease.Calcineurin/NFAT Signaling in Activated Astrocytes Drives Network Hyperexcitability in Aβ-Bearing Mice.Age-related synaptic dysfunction in Tg2576 mice starts as a failure in early long-term potentiation which develops into a full abolishment of late long-term potentiation.Calcineurin proteolysis in astrocytes: Implications for impaired synaptic function Non-amyloidogenic effects of α2 adrenergic agonists: implications for brimonidine-mediated neuroprotection.Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease.Near infrared light decreases synaptic vulnerability to amyloid beta oligomers.Zinc as a Gatekeeper of Immune Function.

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P2860

Selective induction of calcineurin activity and signaling by oligomeric amyloid beta

http://www.wikidata.org/entity/Q34194579

description

2008 nî lūn-bûn

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2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Selective induction of calcineurin activity and signaling by oligomeric amyloid beta

@ast

Selective induction of calcineurin activity and signaling by oligomeric amyloid beta

@en

Selective induction of calcineurin activity and signaling by oligomeric amyloid beta

@nl

type

label

Selective induction of calcineurin activity and signaling by oligomeric amyloid beta

@ast

Selective induction of calcineurin activity and signaling by oligomeric amyloid beta

@en

Selective induction of calcineurin activity and signaling by oligomeric amyloid beta

@nl

prefLabel

Selective induction of calcineurin activity and signaling by oligomeric amyloid beta

@ast

Selective induction of calcineurin activity and signaling by oligomeric amyloid beta

@en

Selective induction of calcineurin activity and signaling by oligomeric amyloid beta

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J.1474-9726.2008.00434.X

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Selective induction of calcineurin activity and signaling by oligomeric amyloid beta

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Giulio Taglialatela

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Kelly T Dineley

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Lindsay C Reese

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Rakez Kayed

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WenRu Zhang

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P2860

Time course of the development of Alzheimer-like pathology in the doubly transgenic PS1+APP mouse

Protein misfolding, functional amyloid, and human disease

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain

Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

Immunopharmacology of rapamycin

Regulation of NMDA receptor trafficking by amyloid-beta

Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

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824-835

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scholarly article

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