Cytoskeletal mechanics of proplatelet maturation and platelet release. - Wikidata - thesis-toulmin - TriplyDB

Cytoskeletal mechanics of proplatelet maturation and platelet release.

Cytoskeletal mechanics of proplatelet maturation and platelet release.

http://www.wikidata.org/entity/Q34317068

about

ACTN1 mutations cause congenital macrothrombocytopenia Platelets in Pulmonary Immune Responses and Inflammatory Lung Diseases Platelet generation in vivo and in vitro Understanding platelet generation from megakaryocytes: implications for in vitro-derived platelets Linkage between the mechanisms of thrombocytopenia and thrombopoiesis IL-1α induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs.Terminal platelet production is regulated by von Willebrand factor Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming Microfluidic model of the platelet-generating organ: beyond bone marrow biomimetics The secret life of a megakaryocyte: emerging roles in bone marrow homeostasis control Proteasome function is required for platelet production Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function.Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet function Myosin-II inhibition and soft 2D matrix maximize multinucleation and cellular projections typical of platelet-producing megakaryocytes.The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation.High-content live-cell imaging assay used to establish mechanism of trastuzumab emtansine (T-DM1)--mediated inhibition of platelet production.A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis.T granules in human platelets function in TLR9 organization and signaling.LIM kinase/cofilin dysregulation promotes macrothrombocytopenia in severe von Willebrand disease-type 2B.Outside-in signalling generated by a constitutively activated integrin αIIbβ3 impairs proplatelet formation in human megakaryocytes.FlnA-null megakaryocytes prematurely release large and fragile platelets that circulate poorly.Mouse models of MYH9-related disease: mutations in nonmuscle myosin II-A.Does size matter in platelet production?Inherited thrombocytopenias: an approach to diagnosis and management.TUBB1 mutation disrupting microtubule assembly impairs proplatelet formation and results in congenital macrothrombocytopenia.Lessons in platelet production from inherited thrombocytopenias.Interpreting the developmental dance of the megakaryocyte: a review of the cellular and molecular processes mediating platelet formation.Myosin-II repression favors pre/proplatelets but shear activation generates platelets and fails in macrothrombocytopenia Microtubule sliding drives proplatelet elongation and is dependent on cytoplasmic dynein.Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization.Manipulating megakaryocytes to manufacture platelets ex vivo.Cytoskeletal perturbation leads to platelet dysfunction and thrombocytopenia in variant forms of Glanzmann thrombasthenia Synthesis and dephosphorylation of MARCKS in the late stages of megakaryocyte maturation drive proplatelet formation.Congenital macrothrombocytopenia-linked mutations in the actin-binding domain of α-actinin-1 enhance F-actin association.Megakaryocytes from CYCS mutation-associated thrombocytopenia release platelets by both proplatelet-dependent and -independent processes.Gfi1b controls integrin signaling-dependent cytoskeleton dynamics and organization in megakaryocytes.Platelet bioreactor: accelerated evolution of design and manufacture.Loss-of-Function Mutations in KIF15 Underlying a Braddock-Carey Genocopy.The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors.Towards the Manufacture of Megakaryocytes and Platelets for Clinical Application.

P2860

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P2860

Cytoskeletal mechanics of proplatelet maturation and platelet release.

http://www.wikidata.org/entity/Q34317068

description

2010 nî lūn-bûn

@nan

2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

@zh-hk

2010年論文

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2010年論文

@zh-tw

2010年论文

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name

Cytoskeletal mechanics of proplatelet maturation and platelet release.

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Cytoskeletal mechanics of proplatelet maturation and platelet release.

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Cytoskeletal mechanics of proplatelet maturation and platelet release.

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type

label

Cytoskeletal mechanics of proplatelet maturation and platelet release.

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Cytoskeletal mechanics of proplatelet maturation and platelet release.

@en

Cytoskeletal mechanics of proplatelet maturation and platelet release.

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prefLabel

Cytoskeletal mechanics of proplatelet maturation and platelet release.

@ast

Cytoskeletal mechanics of proplatelet maturation and platelet release.

@en

Cytoskeletal mechanics of proplatelet maturation and platelet release.

@nl

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Journal of Cell Biology

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Cytoskeletal mechanics of proplatelet maturation and platelet release

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P2093

Alejandro Montalvo

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Jennifer L Richardson

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John H Hartwig

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Jonathan N Thon

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Joseph E Italiano

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Karin Hoffmeister

http://www.w3.org/2001/XMLSchema#string

Mark K Larson

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Matthew T Devine

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Sunita Patel-Hett

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P2860

Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development

Mechanisms of organelle transport and capture along proplatelets during platelet production.

Visualization of microtubule growth in living platelets reveals a dynamic marginal band with multiple microtubules.

Hematopoietic-specific beta 1 tubulin participates in a pathway of platelet biogenesis dependent on the transcription factor NF-E2.

Molecular and transcriptional regulation of megakaryocyte differentiation.

Mechanisms and implications of platelet discoid shape.

Megakaryocyte morphogenesis stimulated in vitro by whole and partially fractionated thrombocytopenic plasma: a model system for the study of platelet formation.

Mice lacking transcription factor NF-E2 provide in vivo validation of the proplatelet model of thrombocytopoiesis and show a platelet production defect that is intrinsic to megakaryocytes.

The platelet interior revisited: electron tomography reveals tubular alpha-granule subtypes.

Anucleate platelets generate progeny

P304

861-874

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scholarly article

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10.1083/JCB.201006102

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4

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191

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Allen Ehrlicher

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2010-11-01T00:00:00Z

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47794581

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21079248

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2983072

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