DPP10 splice variants are localized in distinct neuronal populations and act to differentially regulate the inactivation properties of Kv4-based ion channels
about
Kv4.2 and accessory dipeptidyl peptidase-like protein 10 (DPP10) subunit preferentially form a 4:2 (Kv4.2:DPP10) channel complexS-glutathionylation of an auxiliary subunit confers redox sensitivity to Kv4 channel inactivationDipeptidyl peptidase-like protein 6 is required for normal electrophysiological properties of cerebellar granule cellsA novel DPP6 isoform (DPP6-E) can account for differences between neuronal and reconstituted A-type K(+) channels.Dipeptidyl peptidase 10 (DPP10(789)): a voltage gated potassium channel associated protein is abnormally expressed in Alzheimer's and other neurodegenerative diseases.Incorporation of DPP6a and DPP6K variants in ternary Kv4 channel complex reconstitutes properties of A-type K current in rat cerebellar granule cells.Kv4 channels underlie A-currents with highly variable inactivation time courses but homogeneous other gating properties in the nucleus tractus solitarii.A new TASK for Dipeptidyl Peptidase-like Protein 6.Modeling-independent elucidation of inactivation pathways in recombinant and native A-type Kv channels.A novel N-terminal motif of dipeptidyl peptidase-like proteins produces rapid inactivation of KV4.2 channels by a pore-blocking mechanism.Kv4 accessory protein DPPX (DPP6) is a critical regulator of membrane excitability in hippocampal CA1 pyramidal neuronsDPP6 Localization in Brain Supports Function as a Kv4 Channel Associated ProteinThe neuronal Kv4 channel complex.Multiple intermediate states precede pore block during N-type inactivation of a voltage-gated potassium channel.Weighing the evidence for a ternary protein complex mediating A-type K+ currents in neurons.Dipeptidyl peptidase (DP) 6 and DP10: novel brain proteins implicated in human health and disease.Modulatory mechanisms and multiple functions of somatodendritic A-type K (+) channel auxiliary subunitsT-type channels buddy up.Structure of human dipeptidyl peptidase 10 (DPPY): a modulator of neuronal Kv4 channels.Role of A-type potassium currents in excitability, network synchronicity, and epilepsy.Multiple Kv channel-interacting proteins contain an N-terminal transmembrane domain that regulates Kv4 channel trafficking and gating.Ternary Kv4.2 channels recapitulate voltage-dependent inactivation kinetics of A-type K+ channels in cerebellar granule neurons.Manipulation of Dipeptidylpeptidase 10 in mouse and human in vivo and in vitro models indicates a protective role in asthma.Immunohistochemical localization of DPP10 in rat brain supports the existence of a Kv4/KChIP/DPPL ternary complex in neurons.Interaction of DPP10a with Kv4.3 channel complex results in a sustained current component of human transient outward current Ito.
P2860
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P2860
DPP10 splice variants are localized in distinct neuronal populations and act to differentially regulate the inactivation properties of Kv4-based ion channels
description
2007 nî lūn-bûn
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2007 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մարտին հրատարակված գիտական հոդված
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2007年の論文
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2007年論文
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2007年論文
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2007年論文
@zh-hk
2007年論文
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2007年論文
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2007年论文
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name
DPP10 splice variants are loca ...... ties of Kv4-based ion channels
@ast
DPP10 splice variants are loca ...... ties of Kv4-based ion channels
@en
DPP10 splice variants are loca ...... ties of Kv4-based ion channels
@nl
type
label
DPP10 splice variants are loca ...... ties of Kv4-based ion channels
@ast
DPP10 splice variants are loca ...... ties of Kv4-based ion channels
@en
DPP10 splice variants are loca ...... ties of Kv4-based ion channels
@nl
prefLabel
DPP10 splice variants are loca ...... ties of Kv4-based ion channels
@ast
DPP10 splice variants are loca ...... ties of Kv4-based ion channels
@en
DPP10 splice variants are loca ...... ties of Kv4-based ion channels
@nl
P2093
P2860
P1476
DPP10 splice variants are loca ...... ties of Kv4-based ion channels
@en
P2093
Aaron D Lauver
Henry H Jerng
Paul J Pfaffinger
P2860
P304
P356
10.1016/J.MCN.2007.03.008
P577
2007-03-23T00:00:00Z