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Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activityThe Matricellular Receptor LRP1 Forms an Interface for Signaling and Endocytosis in Modulation of the Extracellular Tumor EnvironmentInvolvement of heparanase in atherosclerosis and other vessel wall pathologiesNephroprotective effect of heparanase in experimental nephrotic syndromeImpact of heparanase on renal fibrosisIdentification of a cytotoxic form of dimeric interleukin-2 in murine tissuesMechanisms of heparanase inhibitors in cancer therapy.Cathepsin L is responsible for processing and activation of proheparanase through multiple cleavages of a linker segment.Heparanase promotes engraftment and prevents graft versus host disease in stem cell transplantationExpression of heparanase in soft tissue sarcomas of adults.Regulation of intracellular signaling by extracellular glycan remodeling.A novel human heparanase splice variant, T5, endowed with protumorigenic characteristics.Heparanase is preferentially expressed in human psoriatic lesions and induces development of psoriasiform skin inflammation in mice.Versatile role of heparanase in inflammationUnraveling the specificity of heparanase utilizing synthetic substrates.Heparanase upregulates Th2 cytokines, ameliorating experimental autoimmune encephalitis.Heparanase levels are elevated in the urine and plasma of type 2 diabetes patients and associate with blood glucose levelsEpidermal growth factor-induced heparanase nucleolar localization augments DNA topoisomerase I activity in brain metastatic breast cancer.Heparanase-induced GEF-H1 signaling regulates the cytoskeletal dynamics of brain metastatic breast cancer cells.CXCL7-Mediated Stimulation of Lymphangiogenic Factors VEGF-C, VEGF-D in Human Breast Cancer CellsHeparanase cooperates with Ras to drive breast and skin tumorigenesisTumorigenic and adhesive properties of heparanase.Heparanase regulates retention and proliferation of primitive Sca-1+/c-Kit+/Lin- cells via modulation of the bone marrow microenvironment.Heparanase enhances myeloma progression via CXCL10 downregulation.Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis.Processing of heparanase is mediated by syndecan-1 cytoplasmic domain and involves syntenin and α-actinin.Elevated urine heparanase levels are associated with proteinuria and decreased renal allograft functionPrognostic value of heparanase expression and cellular localization in oral cancer.Clinical significance of heparanase splice variant (t5) in renal cell carcinoma: evaluation by a novel t5-specific monoclonal antibodySecondary storage of dermatan sulfate in Sanfilippo disease.Pre-clinical and clinical significance of heparanase in Ewing's sarcoma.Heparan sulfate proteoglycans.Interleukin-2 is present in human blood vessels and released in biologically active form by heparanase.Upregulation of VEGF-A and CD24 gene expression by the tGLI1 transcription factor contributes to the aggressive behavior of breast cancer cells.Post-transcriptional regulation of heparanase gene expression by a 3' AU-rich elementHeparanase stimulates chondrogenesis and is up-regulated in human ectopic cartilage: a mechanism possibly involved in hereditary multiple exostoses.High glucose-induced intestinal epithelial barrier damage is aggravated by syndecan-1 destruction and heparanase overexpression.Recent data concerning heparanase: focus on fibrosis, inflammation and cancer.Heparanase induces signal transducer and activator of transcription (STAT) protein phosphorylation: preclinical and clinical significance in head and neck cancerTie2 Expressing Monocytes in the Spleen of Patients with Primary Myelofibrosis.
P2860
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P2860
description
2007 nî lūn-bûn
@nan
2007 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Mammalian heparanase: what is the message?
@ast
Mammalian heparanase: what is the message?
@en
Mammalian heparanase: what is the message?
@nl
type
label
Mammalian heparanase: what is the message?
@ast
Mammalian heparanase: what is the message?
@en
Mammalian heparanase: what is the message?
@nl
prefLabel
Mammalian heparanase: what is the message?
@ast
Mammalian heparanase: what is the message?
@en
Mammalian heparanase: what is the message?
@nl
P2860
P1476
Mammalian heparanase: what is the message?
@en
P2093
Guido David
P2860
P304
P356
10.1111/J.1582-4934.2007.00039.X
P577
2007-05-01T00:00:00Z