Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide - Wikidata - thesis-toulmin - TriplyDB

Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide

Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide

http://www.wikidata.org/entity/Q35032502

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A new paradigm of DNA synthesis: three-metal-ion catalysis.Reactive Oxygen Species Play an Important Role in the Bactericidal Activity of Quinolone Antibiotics A fidelity mechanism in DNA polymerase lambda promotes error-free bypass of 8-oxo-dG Oxidant and environmental toxicant-induced effects compromise DNA ligation during base excision DNA repair Insights into Watson-Crick/Hoogsteen breathing dynamics and damage repair from the solution structure and dynamic ensemble of DNA duplexes containing m1A.Capturing a mammalian DNA polymerase extending from an oxidized nucleotide.Viewing Human DNA Polymerase β Faithfully and Unfaithfully Bypass an Oxidative Lesion by Time-Dependent Crystallography New structural snapshots provide molecular insights into the mechanism of high fidelity DNA synthesis.Slow Replication Fork Velocity of Homologous Recombination-Defective Cells Results from Endogenous Oxidative Stress Requirement for transient metal ions revealed through computational analysis for DNA polymerase going in reverse.Nucleotide binding interactions modulate dNTP selectivity and facilitate 8-oxo-dGTP incorporation by DNA polymerase lambda.Echinacoside induces apoptotic cancer cell death by inhibiting the nucleotide pool sanitizing enzyme MTH1.Reprint of "Oxidant and environmental toxicant-induced effects compromise DNA ligation during base excision DNA repair".DNA mismatch repair and the DNA damage response.Insertion of oxidized nucleotide triggers rapid DNA polymerase opening Oxidized dNTPs and the OGG1 and MUTYH DNA glycosylases combine to induce CAG/CTG repeat instability.Divalent ions attenuate DNA synthesis by human DNA polymerase α by changing the structure of the template/primer or by perturbing the polymerase reaction.Oxidized nucleotide insertion by pol β confounds ligation during base excision repair.Time-lapse crystallography snapshots of a double-strand break repair polymerase in action Oxidative guanine base damage regulates human telomerase activity.Base excision repair of oxidative DNA damage: from mechanism to disease.Exploring the mechanism of DNA polymerases by analyzing the effect of mutations of active site acidic groups in Polymerase β Role of DNA polymerase β oxidized nucleotide insertion in DNA ligation failure.Crystal structures of ternary complexes of archaeal B-family DNA polymerases.The m6A methylation perturbs the Hoogsteen pairing-guided incorporation of an oxidized nucleotide.Molecular snapshots of APE1 proofreading mismatches and removing DNA damage.Modulating the DNA polymerase β reaction equilibrium to dissect the reverse reaction.Protocols for Molecular Dynamics Simulations of RNA Nanostructures.Is There Still Any Role for Oxidative Stress in Mitochondrial DNA-Dependent Aging?Pol μ dGTP mismatch insertion opposite T coupled with ligation reveals promutagenic DNA repair intermediate

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Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide

http://www.wikidata.org/entity/Q35032502

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2014 nî lūn-bûn

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2014 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

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2014年論文

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2014年论文

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name

Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide

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Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide

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Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide

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Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide

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Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide

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Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide

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Bret D Freudenthal

http://www.w3.org/2001/XMLSchema#string

David D Shock

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Taejin Kim

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Tamar Schlick

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William A Beard

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P2860

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Processing of X-ray diffraction data collected in oscillation mode

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

Mutagenic conformation of 8-oxo-7,8-dihydro-2′-dGTP in the confines of a DNA polymerase active site

Watching DNA polymerase η make a phosphodiester bond

DNA polymerase minor groove interactions modulate mutagenic bypass of a templating 8-oxoguanine lesion

Observing a DNA Polymerase Choose Right from Wrong

Structural Basis for Promutagenicity of 8-Halogenated Guanine

Crystal Structure of DNA Polymerase β with DNA Containing the Base Lesion Spiroiminodihydantoin in a Templating Position

Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy

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10.1038/NATURE13886

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Samuel H. Wilson

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2014-11-17T00:00:00Z

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268791287

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