An aptamer-siRNA chimera suppresses HIV-1 viral loads and protects from helper CD4(+) T cell decline in humanized mice. - Wikidata - thesis-toulmin - TriplyDB

An aptamer-siRNA chimera suppresses HIV-1 viral loads and protects from helper CD4(+) T cell decline in humanized mice.

An aptamer-siRNA chimera suppresses HIV-1 viral loads and protects from helper CD4(+) T cell decline in humanized mice.

http://www.wikidata.org/entity/Q35111705

about

Highly significant antiviral activity of HIV-1 LTR-specific tre-recombinase in humanized mice Engineering HIV-1-resistant T-cells from short-hairpin RNA-expressing hematopoietic stem/progenitor cells in humanized BLT mice Targeting Th17 Cells with Small Molecules and Small Interference RNA Bone Marrow Gene Therapy for HIV/AIDS Biosafe nanoscale pharmaceutical adjuvant materials Studies of retroviral infection in humanized mice Pre-clinical modeling of CCR5 knockout in human hematopoietic stem cells by zinc finger nucleases using humanized mice Genetically modified hematopoietic stem cell transplantation for HIV-1-infected patients: can we achieve a cure?Nucleic Acid aptamers: new methods for selection, stabilization, and application in biomedical science Aptamers in diagnostics and treatment of viral infections New generation humanized mice for virus research: comparative aspects and future prospects Gene therapy strategies for HIV/AIDS: preclinical modeling in humanized mice Smart functional nucleic acid chimeras: enabling tissue specific RNA targeting therapy Aptamer-Mediated Targeted Delivery of Therapeutics: An Update Using animal models to overcome temporal, spatial and combinatorial challenges in HIV persistence research Use of Aptamers as Diagnostics Tools and Antiviral Agents for Human Viruses Manipulating the in vivo immune response by targeted gene knockdown Engineering T Cells to Functionally Cure HIV-1 Infection Technologies for controlled, local delivery of siRNA Progress toward in vivo use of siRNAs-II Excision of HIV-1 proviral DNA by recombinant cell permeable tre-recombinase A novel class of anti-HIV agents with multiple copies of enfuvirtide enhances inhibition of viral replication and cellular transmission in vitro Animal models for HIV/AIDS research Aptamer in bioanalytical applications.Preparation of biocompatible heat-labile enterotoxin subunit B-bovine serum albumin nanoparticles for improving tumor-targeted drug delivery via heat-labile enterotoxin subunit B mediation.Intranasal drug delivery of small interfering RNA targeting Beclin1 encapsulated with polyethylenimine (PEI) in mouse brain to achieve HIV attenuation.siRNA against KIR3DL1 as a potential gene therapeutic agent in controlling HIV-1 infection.Multifunctional aptamer-miRNA conjugates for targeted cancer therapy.Cell-type-specific, Aptamer-functionalized Agents for Targeted Disease Therapy Targeting 4-1BB costimulation to the tumor stroma with bispecific aptamer conjugates enhances the therapeutic index of tumor immunotherapy.Humanized Rag1-/- γc-/- mice support multilineage hematopoiesis and are susceptible to HIV-1 infection via systemic and vaginal routes Nucleic acid aptamers: clinical applications and promising new horizons Efficient HIV-1 inhibition by a 16 nt-long RNA aptamer designed by combining in vitro selection and in silico optimisation strategies.Hybrid compounds: from simple combinations to nanomachines.Aptamers in virology: recent advances and challenges.Cell-type-specific aptamer and aptamer-small interfering RNA conjugates for targeted human immunodeficiency virus type 1 therapy.TLR9-mediated siRNA delivery for targeting of normal and malignant human hematopoietic cells in vivo Current humanized mouse models for studying human immunology and HIV-1 immuno-pathogenesis.Transcriptional gene silencing in humans.Human immunodeficiency virus-1 (HIV-1)-mediated apoptosis: new therapeutic targets.

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An aptamer-siRNA chimera suppresses HIV-1 viral loads and protects from helper CD4(+) T cell decline in humanized mice.

http://www.wikidata.org/entity/Q35111705

description

2011 nî lūn-bûn

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2011 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2011 թվականի հունվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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An aptamer-siRNA chimera suppr ...... ell decline in humanized mice.

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An aptamer-siRNA chimera suppr ...... ell decline in humanized mice.

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Charles Preston Neff

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David D Smith

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Haitang Li

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Jane Zhang

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Jes Kuruvilla

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Jiehua Zhou

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John J Rossi

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Leila Remling

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Piotr Swiderski

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Ramesh Akkina

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P2860

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs

T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice

The promises and pitfalls of RNA-interference-based therapeutics

Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase

In vitro selection of RNA molecules that bind specific ligands

Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes

Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells

B cells in HIV infection and disease

Mucosal transmission of R5 and X4 tropic HIV-1 via vaginal and rectal routes in humanized Rag2-/- gammac -/- (RAG-hu) mice.

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