Functional interactions of Prp8 with both splice sites at the spliceosomal catalytic center.
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The human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formation.The 65 and 110 kDa SR-related proteins of the U4/U6.U5 tri-snRNP are essential for the assembly of mature spliceosomesA novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site.Prp8 protein: at the heart of the spliceosomeThe network of protein-protein interactions within the human U4/U6.U5 tri-snRNPAn upstream AG determines whether a downstream AG is selected during catalytic step II of splicingThe spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctionsPre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctionsExtended base pair complementarity between U1 snRNA and the 5' splice site does not inhibit splicing in higher eukaryotes, but rather increases 5' splice site recognitionThe architecture of the spliceosomal U4/U6.U5 tri-snRNP.Crystal structure of the functional domain of the splicing factor Prp18Crystal structure of the -finger domain of Prp8 reveals analogy to ribosomal proteinsStructure and function of an RNase H domain at the heart of the spliceosomeStructural basis for dual roles of Aar2p in U5 snRNP assemblyA conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligationEvidence for a role of Sky1p-mediated phosphorylation in 3' splice site recognition involving both Prp8 and Prp17/Slu4.The Isy1p component of the NineTeen complex interacts with the ATPase Prp16p to regulate the fidelity of pre-mRNA splicing.Functional interactions between Prp8, Prp18, Slu7, and U5 snRNA during the second step of pre-mRNA splicing.The yeast U5 snRNP coisolated with the U1 snRNP has an unexpected protein composition and includes the splicing factor Aar2pSplicing proofreading at 5' splice sites by ATPase Prp28p.Prp8 retinitis pigmentosa mutants cause defects in the transition between the catalytic steps of splicing.CEF1/CDC5 alleles modulate transitions between catalytic conformations of the spliceosome.Central region of the human splicing factor Hprp3p interacts with Hprp4pATP-dependent interaction of yeast U5 snRNA loop 1 with the 5' splice site.A ribozyme selected from variants of U6 snRNA promotes 2',5'-branch formationThe 100-kda U5 snRNP protein (hPrp28p) contacts the 5' splice site through its ATPase siteRNA structure analysis of human spliceosomes reveals a compact 3D arrangement of snRNAs at the catalytic core.Defining a 5' splice site by functional selection in the presence and absence of U1 snRNA 5' end.A general approach for identification of RNA-protein cross-linking sites within native human spliceosomal small nuclear ribonucleoproteins (snRNPs). Analysis of RNA-protein contacts in native U1 and U4/U6.U5 snRNPs.From the ribosome to the spliceosome and back again.SF3b1 mutations associated with myelodysplastic syndromes alter the fidelity of branchsite selection in yeastInteraction of the yeast DExH-box RNA helicase prp22p with the 3' splice site during the second step of nuclear pre-mRNA splicingSpliceosomal introns in the deep-branching eukaryote Trichomonas vaginalisDistinct domains of splicing factor Prp8 mediate different aspects of spliceosome activationProximity of the invariant loop of U5 snRNA to the second intron residue during pre-mRNA splicing.trans and cis splicing in trypanosomatids: mechanism, factors, and regulation.A tertiary interaction detected in a human U2-U6 snRNA complex assembled in vitro resembles a genetically proven interaction in yeast.Splicing enhancement in the yeast rp51b intron.Identification of a U2/U6 helix la mutant that influences 3' splice site selection during nuclear pre-mRNA splicing.Genetic interactions between the 5' and 3' splice site consensus sequences and U6 snRNA during the second catalytic step of pre-mRNA splicing.
P2860
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P2860
Functional interactions of Prp8 with both splice sites at the spliceosomal catalytic center.
description
1999 nî lūn-bûn
@nan
1999 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Functional interactions of Prp ...... spliceosomal catalytic center.
@ast
Functional interactions of Prp ...... spliceosomal catalytic center.
@en
type
label
Functional interactions of Prp ...... spliceosomal catalytic center.
@ast
Functional interactions of Prp ...... spliceosomal catalytic center.
@en
prefLabel
Functional interactions of Prp ...... spliceosomal catalytic center.
@ast
Functional interactions of Prp ...... spliceosomal catalytic center.
@en
P2093
P2860
P356
P1433
P1476
Functional interactions of Prp ...... spliceosomal catalytic center.
@en
P2093
M M Konarska
M Siatecka
P2860
P304
P356
10.1101/GAD.13.15.1983
P577
1999-08-01T00:00:00Z