Targeted disruption of the orphanin FQ/nociceptin gene increases stress susceptibility and impairs stress adaptation in mice.
about
Pharmacology of nociceptin and its receptor: a novel therapeutic targetNeuropeptide regulation of signaling and behavior in the BNST.Neuropeptide modulation of central amygdala neuroplasticity is a key mediator of alcohol dependence.Nociceptin and the nociceptin receptor in learning and memory50 years of hurdles and hope in anxiolytic drug discoveryControl of glutamate and GABA release by nociceptin/orphanin FQ in the rat lateral amygdalaNeuropeptides: developmental signals in placode progenitor formationNeuropeptidergic signaling partitions arousal behaviors in zebrafish.The role of orphanin FQ/nociceptin in neuroplasticity: relationship to stress, anxiety and neuroinflammation.The clinical implications of mouse models of enhanced anxiety.The bed nucleus is a neuroanatomical substrate for the anorectic effect of corticotropin-releasing factor and for its reversal by nociceptin/orphanin FQ.Hypocretin/orexin and nociceptin/orphanin FQ coordinately regulate analgesia in a mouse model of stress-induced analgesia.Emergence of anxiety-like behaviours in depressive-like Cpe(fat/fat) miceChronic treatment with novel brain-penetrating selective NOP receptor agonist MT-7716 reduces alcohol drinking and seeking in the ratRole of opioid receptor like-1 receptor in modulation of endocrine, immunological, and behavioral responses to the T-cell superantigen staphylococcal enterotoxin AMPTP treatment increases expression of pre-pro-nociceptin/orphanin FQ mRNA in a subset of substantia nigra reticulata neurons.A combined pharmacological and genetic approach to investigate the role of orphanin FQ in learning and memory.Anorexia nervosa: a unified neurological perspectiveAnxiolytic effects of the MCH1R antagonist TPI 1361-17.Direct inhibition of hypocretin/orexin neurons in the lateral hypothalamus by nociceptin/orphanin FQ blocks stress-induced analgesia in rats.The pharmacology of Ro 64-6198, a systemically active, nonpeptide NOP receptor (opiate receptor-like 1, ORL-1) agonist with diverse preclinical therapeutic activity.Central injections of nocistatin or its C-terminal hexapeptide exert anxiogenic-like effect on behaviour of mice in the plus-maze testNociceptin/orphanin FQ: actions within the brain.Orphanin FQ/nociceptin interacts with the basolateral amygdala noradrenergic system in memory consolidation.Social Regulation of Gene Expression in Threespine SticklebacksEndogenous nociceptin/orphanin-FQ in the dorsal hippocampus facilitates despair-related behavior.Effect of orphanin FQ/nociceptin (OFQ/N) and isoflurane on the prolactin secretory response in OFQ/N knockout mice.The central amygdala and alcohol: role of γ-aminobutyric acid, glutamate, and neuropeptidesDisruption of the circadian output molecule prokineticin 2 results in anxiolytic and antidepressant-like effects in miceThe biology of Nociceptin/Orphanin FQ (N/OFQ) related to obesity, stress, anxiety, mood, and drug dependence.MT-7716, a novel selective nonpeptidergic NOP receptor agonist, effectively blocks ethanol-induced increase in GABAergic transmission in the rat central amygdala.UFP-112 a potent and long-lasting agonist selective for the Nociceptin/Orphanin FQ receptor.New Technologies for Elucidating Opioid Receptor Function.N/OFQ system in brain areas of nerve-injured mice: its role in different aspects of neuropathic pain.Characterization of [Nphe(1)]nociceptin(1-13)NH(2), a new selective nociceptin receptor antagonist.Parsing the hedonic and motivational influences of nociceptin on feeding using licking microstructure analysis in mice.Endogenous nociceptin / orphanin FQ system involvement in hypothalamic-pituitary-adrenal axis responses: relevance to models of inflammation.Nociceptin/orphanin FQ modulates the cardiovascular, but not renal, responses to stress in spontaneously hypertensive rats.Role of nociceptin/orphanin FQ and NOP receptors in the response to acute and repeated restraint stress in rats.Usefulness of knockout mice to clarify the role of the opioid system in chronic pain.
P2860
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P2860
Targeted disruption of the orphanin FQ/nociceptin gene increases stress susceptibility and impairs stress adaptation in mice.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Targeted disruption of the orp ...... irs stress adaptation in mice.
@ast
Targeted disruption of the orp ...... irs stress adaptation in mice.
@en
type
label
Targeted disruption of the orp ...... irs stress adaptation in mice.
@ast
Targeted disruption of the orp ...... irs stress adaptation in mice.
@en
prefLabel
Targeted disruption of the orp ...... irs stress adaptation in mice.
@ast
Targeted disruption of the orp ...... irs stress adaptation in mice.
@en
P2093
P2860
P356
P1476
Targeted disruption of the orp ...... irs stress adaptation in mice.
@en
P2093
A Montkowski
H P Nothacker
J L Moreau
R K Reinscheid
P2860
P304
10444-10449
P356
10.1073/PNAS.96.18.10444
P407
P577
1999-08-01T00:00:00Z