TP53 intron 1 hotspot rearrangements are specific to sporadic osteosarcoma and can cause Li-Fraumeni syndrome.
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Emerging Role of Genomic Rearrangements in Breast Cancer: Applying Knowledge from Other CancersNew small molecules targeting apoptosis and cell viability in osteosarcomaGenome Analysis of Osteosarcoma Progression Samples Identifies FGFR1 Overexpression as a Potential Treatment Target and CHM as a Candidate Tumor Suppressor GeneAssociations of polymorphisms in NAT2 gene with risk and metastasis of osteosarcoma in young Chinese population.[Hereditary bone tumors].Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiencyActivation of PTHrP-cAMP-CREB1 signaling following p53 loss is essential for osteosarcoma initiation and maintenance.Unscrambling the genomic chaos of osteosarcoma reveals extensive transcript fusion, recurrent rearrangements and frequent novel TP53 aberrationsTargeted next-generation sequencing of dedifferentiated chondrosarcoma in the skull base reveals combined TP53 and PTEN mutations with increased proliferation index, an implication for pathogenesis.A novel TP53-KPNA3 translocation defines a de novo treatment-resistant clone in osteosarcomaSomatic TP53 Mutations in the Era of Genome Sequencing.Molecular genetics of osteosarcoma.Genome-wide analysis of somatic copy number alterations and chromosomal breakages in osteosarcoma.[Pathogenesis and genetics of osteosarcoma : Current concepts and developments].Detection of circulating tumor DNA in patients with osteosarcoma.Whole-exome sequencing in osteosarcoma reveals important heterogeneity of genetic alterations.Tolerance to sustained activation of the cAMP/Creb pathway activity in osteoblastic cells is enabled by loss of p53Breast cancer patients suggestive of Li-Fraumeni syndrome: mutational spectrum, candidate genes, and unexplained heredity
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TP53 intron 1 hotspot rearrangements are specific to sporadic osteosarcoma and can cause Li-Fraumeni syndrome.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
TP53 intron 1 hotspot rearrang ...... an cause Li-Fraumeni syndrome.
@ast
TP53 intron 1 hotspot rearrang ...... an cause Li-Fraumeni syndrome.
@en
type
label
TP53 intron 1 hotspot rearrang ...... an cause Li-Fraumeni syndrome.
@ast
TP53 intron 1 hotspot rearrang ...... an cause Li-Fraumeni syndrome.
@en
prefLabel
TP53 intron 1 hotspot rearrang ...... an cause Li-Fraumeni syndrome.
@ast
TP53 intron 1 hotspot rearrang ...... an cause Li-Fraumeni syndrome.
@en
P2093
P2860
P50
P356
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TP53 intron 1 hotspot rearrang ...... an cause Li-Fraumeni syndrome.
@en
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Audrey S M Teo
Axel M Hillmer
Daniel Baumhoer
Gernot Jundt
Joshua D Schiffman
Kang Zhang
Kristy Lee
Michaela Nathrath
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P304
P356
10.18632/ONCOTARGET.3115
P407
P577
2015-04-01T00:00:00Z