Intranasal delivery of HMGB1 siRNA confers target gene knockdown and robust neuroprotection in the postischemic brain. - Wikidata - thesis-toulmin - TriplyDB

Intranasal delivery of HMGB1 siRNA confers target gene knockdown and robust neuroprotection in the postischemic brain.

Intranasal delivery of HMGB1 siRNA confers target gene knockdown and robust neuroprotection in the postischemic brain.

http://www.wikidata.org/entity/Q35876200

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Formulations for Intranasal Delivery of Pharmacological Agents to Combat Brain Disease: A New Opportunity to Tackle GBM?HMGB1 in health and disease.Protective effect of glycyrrhizin, a direct HMGB1 inhibitor, on focal cerebral ischemia/reperfusion-induced inflammation, oxidative stress, and apoptosis in rats Guanidinylated block copolymers for gene transfer: A comparison with amine-based materials for in vitro and in vivo gene transfer efficiency Systemic dendrimer-drug treatment of ischemia-induced neonatal white matter injury Stress-induced neuroinflammation is mediated by GSK3-dependent TLR4 signaling that promotes susceptibility to depression-like behavior.Inhibition of microRNA-210 provides neuroprotection in hypoxic-ischemic brain injury in neonatal rats.A novel dendritic nanocarrier of polyamidoamine-polyethylene glycol-cyclic RGD for "smart" small interfering RNA delivery and in vitro antitumor effects by human ether-à-go-go-related gene silencing in anaplastic thyroid carcinoma cells Nonviral gene therapy in vivo with PAM-RG4/apoptin as a potential brain tumor therapeutic Intranasal brain delivery of cationic nanoemulsion-encapsulated TNFα siRNA in prevention of experimental neuroinflammation High-mobility group box-1 induces decreased brain-derived neurotrophic factor-mediated neuroprotection in the diabetic retina.Alcohol-induced IL-1β in the brain is mediated by NLRP3/ASC inflammasome activation that amplifies neuroinflammation Intranasal Oncolytic Virotherapy with CXCR4-Enhanced Stem Cells Extends Survival in Mouse Model of Glioma.Emerging role of high-mobility group box 1 (HMGB1) in liver diseases.Ethanol extracts from Portulaca oleracea L. attenuated ischemia/reperfusion induced rat neural injury through inhibition of HMGB1 induced inflammation.siRNA Treatment: "A Sword-in-the-Stone" for Acute Brain Injuries One-Compound-Multi-Target: Combination Prospect of Natural Compounds with Thrombolytic Therapy in Acute Ischemic Stroke.Biodistribution of fluorescently labeled PAMAM dendrimers in neonatal rabbits: effect of neuroinflammation.Down-regulation of nuclear HMGB1 reduces ischemia-induced HMGB1 translocation and release and protects against liver ischemia-reperfusion injury.Drug delivery systems for the treatment of ischemic stroke.Targeted delivery of nano-therapeutics for major disorders of the central nervous system.Small RNA drugs for prion disease: a new frontier.Poly(amidoamine) dendrimer complexes as a platform for gene delivery.Intranasal delivery: circumventing the iron curtain to treat neurological disorders.Role of high-mobility group box-1 protein in disruption of vascular barriers and regulation of leukocyte-endothelial interactions.Targeted delivery of growth factors in ischemic stroke animal models.Destination Brain: the Past, Present, and Future of Therapeutic Gene Delivery.Systems-level thinking for nanoparticle-mediated therapeutic delivery to neurological diseases.Inhibiting HMGB1 with Glycyrrhizic Acid Protects Brain Injury after DAI via Its Anti-Inflammatory Effect.Intranasal, siRNA Delivery to the Brain by TAT/MGF Tagged PEGylated Chitosan Nanoparticles.HMGB1-Binding Heptamer Confers Anti-Inflammatory Effects in Primary Microglia Culture.Intranasal administration of plasmid DNA nanoparticles yields successful transfection and expression of a reporter protein in rat brain.Pivotal neuroinflammatory and therapeutic role of high mobility group box 1 in ischemic stroke.Neuroprotective and Anti-inflammatory Effects of a Dodecamer Peptide Harboring Ninjurin 1 Cell Adhesion Motif in the Postischemic Brain.Short interfering RNA and the central nervous system: development of nonviral delivery systems.microRNA-219 Reduces Viral Load and Pathologic Changes in Theiler's Virus-Induced Demyelinating Disease.Intranasal Delivery of RGD Motif-Containing Osteopontin Icosamer Confers Neuroprotection in the Postischemic Brain via αvβ3 Integrin Binding.Dendrimers as carriers for siRNA delivery and gene silencing: a review.Alarmin HMGB1 induces systemic and brain inflammatory exacerbation in post-stroke infection rat model.Intranasal delivery of a Fas-blocking peptide attenuates Fas-mediated apoptosis in brain ischemia

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Intranasal delivery of HMGB1 siRNA confers target gene knockdown and robust neuroprotection in the postischemic brain.

http://www.wikidata.org/entity/Q35876200

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Intranasal delivery of HMGB1 s ...... ion in the postischemic brain.

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Intranasal delivery of HMGB1 s ...... ion in the postischemic brain.

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Intranasal delivery of HMGB1 s ...... ion in the postischemic brain.

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Intranasal delivery of HMGB1 s ...... ion in the postischemic brain.

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Molecular Therapy

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Intranasal delivery of HMGB1 s ...... tion in the postischemic brain

@en

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Il-Doo Kim

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Ja-Kyeong Lee

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Jong-Sang Park

http://www.w3.org/2001/XMLSchema#string

Joo-Hyun Shin

http://www.w3.org/2001/XMLSchema#string

Junseong Ahn

http://www.w3.org/2001/XMLSchema#string

Seung-Woo Kim

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Sunghyun Choi

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P2860

Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease

Cholecystokinin modulates migration of gonadotropin-releasing hormone-1 neurons

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

HMG-1 as a late mediator of endotoxin lethality in mice

Neuroprotection by biodegradable PAMAM ester (e-PAM-R)-mediated HMGB1 siRNA delivery in primary cortical cultures and in the postischemic brain

Central nervous system effects of intranasally administered insulin during euglycemia in men.

Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion.

Transport of drugs from the nasal cavity to the central nervous system.

Intranasal delivery of cells to the brain.

Is nose-to-brain transport of drugs in man a reality?

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829-839

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10.1038/MT.2011.291

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4

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20

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221754419

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22252450

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3321593

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