Role of the WNK-activated SPAK kinase in regulating blood pressure. - Wikidata - thesis-toulmin - TriplyDB

Role of the WNK-activated SPAK kinase in regulating blood pressure.

Role of the WNK-activated SPAK kinase in regulating blood pressure.

http://www.wikidata.org/entity/Q36039159

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MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters Insulin receptor substrate-2 is expressed in kidney epithelium and up-regulated in diabetic nephropathy Molecular regulation of NKCC2 in the thick ascending limb STK39 polymorphism is associated with essential hypertension: a systematic review and meta-analysis A molecular update on pseudohypoaldosteronism type II Current view on the functional regulation of the neuronal K(+)-Cl(-) cotransporter KCC2 Small-molecule WNK inhibition regulates cardiovascular and renal function Domain-Swapping Switch Point in Ste20 Protein Kinase SPAK A SPAK isoform switch modulates renal salt transport and blood pressure Regulation of NKCC2 activity by inhibitory SPAK isoforms: KS-SPAK is a more potent inhibitor than SPAK2 Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression WNK1 kinase balances T cell adhesion versus migration in vivo Phosphorylation and transport in the Na-K-2Cl cotransporters, NKCC1 and NKCC2A, compared in HEK-293 cells.Increasing plasma [K+] by intravenous potassium infusion reduces NCC phosphorylation and drives kaliuresis and natriuresis.Sympathetic stimulation of thiazide-sensitive sodium chloride cotransport in the generation of salt-sensitive hypertension.A novel Ste20-related proline/alanine-rich kinase (SPAK)-independent pathway involving calcium-binding protein 39 (Cab39) and serine threonine kinase with no lysine member 4 (WNK4) in the activation of Na-K-Cl cotransporters.In silico analysis and experimental verification of OSR1 kinase - Peptide interaction.Acute insulin stimulation induces phosphorylation of the Na-Cl cotransporter in cultured distal mpkDCT cells and mouse kidney.Decreased ENaC expression compensates the increased NCC activity following inactivation of the kidney-specific isoform of WNK1 and prevents hypertension.Hypotonicity stimulates potassium flux through the WNK-SPAK/OSR1 kinase cascade and the Ncc69 sodium-potassium-2-chloride cotransporter in the Drosophila renal tubule.Activation of thiazide-sensitive co-transport by angiotensin II in the cyp1a1-Ren2 hypertensive rat.Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension Short forms of Ste20-related proline/alanine-rich kinase (SPAK) in the kidney are created by aspartyl aminopeptidase (Dnpep)-mediated proteolytic cleavage.Thick ascending limb of the loop of Henle.SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction.Kinase drug discovery--what's next in the field?Downregulation of NCC and NKCC2 cotransporters by kidney-specific WNK1 revealed by gene disruption and transgenic mouse models γ-Adducin stimulates the thiazide-sensitive NaCl cotransporter SPAK deficiency corrects pseudohypoaldosteronism II caused by WNK4 mutation.STE20/SPS1-related proline/alanine-rich kinase (SPAK) is critical for sodium reabsorption in isolated, perfused thick ascending limb.Impaired phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome SPAK-mediated NCC regulation in response to low-K+ diet SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation.Perspective of future drugs targeting sterile 20/SPS1-related proline/alanine-rich kinase for blood pressure control.Critical role of the SPAK protein kinase CCT domain in controlling blood pressure Molecular physiology of SPAK and OSR1: two Ste20-related protein kinases regulating ion transport.WNK4 inhibits NCC protein expression through MAPK ERK1/2 signaling pathway.Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process.

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Role of the WNK-activated SPAK kinase in regulating blood pressure.

http://www.wikidata.org/entity/Q36039159

description

2010 nî lūn-bûn

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年學術文章

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2010年學術文章

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2010年學術文章

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Role of the WNK-activated SPAK kinase in regulating blood pressure.

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Role of the WNK-activated SPAK kinase in regulating blood pressure.

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type

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Role of the WNK-activated SPAK kinase in regulating blood pressure.

@ast

Role of the WNK-activated SPAK kinase in regulating blood pressure.

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prefLabel

Role of the WNK-activated SPAK kinase in regulating blood pressure.

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Role of the WNK-activated SPAK kinase in regulating blood pressure.

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EMBO Molecular Medicine

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Role of the WNK-activated SPAK kinase in regulating blood pressure.

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Aleksandar Jovanović

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Ciaran Richardson

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Fatema H Rafiqi

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Kevin M O'Shaughnessy

http://www.w3.org/2001/XMLSchema#string

Mark Glover

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Sofija Jovanović

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Stewart Fleming

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P2860

Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter

Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2

Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4

Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1

Molecular physiology of the thiazide-sensitive sodium-chloride cotransporter

The thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKs

Cloning and characterization of a new intestinal inflammation-associated colonic epithelial Ste20-related protein kinase isoform

Human hypertension caused by mutations in WNK kinases

WNK1 activates ERK5 by an MEKK2/3-dependent mechanism

The Na+:Cl- cotransporter is activated and phosphorylated at the amino-terminal domain upon intracellular chloride depletion

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63-75

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scholarly article

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10.1002/EMMM.200900058

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2

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2

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Annie Mercier Zuber

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2010-02-01T00:00:00Z

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41104077

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20091762

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3377268

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