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Update of TTD: Therapeutic Target DatabaseSystematic analysis of the associations between adverse drug reactions and pathwaysStrategic applications of gene expression: from drug discovery/development to bedsideSmall-Molecule Scaffolds for CYP51 Inhibitors Identified by High-Throughput Screening and Defined by X-Ray CrystallographyStimulated Raman scattering microscopy: an emerging tool for drug discoveryHuman corneal cell culture models for drug toxicity studiesA structure-based approach for mapping adverse drug reactions to the perturbation of underlying biological pathwaysExploring off-targets and off-systems for adverse drug reactions via chemical-protein interactome--clozapine-induced agranulocytosis as a case studyNetwork neighbors of drug targets contribute to drug side-effect similarityCharacterizing the network of drugs and their affected metabolic subpathwaysMetabolism of BYZX in human liver microsomes and cytosol: identification of the metabolites and metabolic pathways of BYZXThe novel tubulin polymerization inhibitor MHPT exhibits selective anti-tumor activity against rhabdomyosarcoma in vitro and in vivoAMPK Activation Prevents and Reverses Drug-Induced Mitochondrial and Hepatocyte Injury by Promoting Mitochondrial Fusion and FunctionA side effect resource to capture phenotypic effects of drugsDrug target identification using side-effect similarityLarge-scale prediction of drug-target relationshipsAnalytical tools and approaches for metabolite identification in early drug discovery.Relationships Between Pharmacovigilance, Molecular, Structural, and Pathway Data: Revealing Mechanisms for Immune-Mediated Drug-Induced Liver Injury.DTNI: a novel toxicogenomics data analysis tool for identifying the molecular mechanisms underlying the adverse effects of toxic compounds.Analysis of protein adduction kinetics by quantitative mass spectrometry: competing adduction reactions of glutathione-S-transferase P1-1 with electrophiles.WDR23 regulates NRF2 independently of KEAP1.Age-related changes in redox signaling and VSMC function.Integrative computational protocol for the discovery of inhibitors of the Helicobacter pylori nickel response regulator (NikR).Identification of mutant Asp251Gly/Gln307His of cytochrome P450 BM3 for the generation of metabolites of diclofenac, ibuprofen and tolbutamide.Genome-wide screening identifies new genes required for stress-induced phase 2 detoxification gene expression in animals.Myelosuppression and kinase selectivity of multikinase angiogenesis inhibitors.What can crystal structures of aminergic receptors tell us about designing subtype-selective ligands?In silico toxicology - non-testing methods.Characterizing protein modifications by reactive metabolites using magnetic bead bioreactors and LC-MS/MSElucidating Organ-Specific Metabolic Toxicity Chemistry from Electrochemiluminescent Enzyme/DNA Arrays and Bioreactor Bead-LC-MS/MS.Automatic signal extraction, prioritizing and filtering approaches in detecting post-marketing cardiovascular events associated with targeted cancer drugs from the FDA Adverse Event Reporting System (FAERS)Modular Synthesis of Novel Macrocycles Bearing α,β-Unsaturated Chemotypes through a Series of One-Pot, Sequential Protocols.Metabolic toxicity screening using electrochemiluminescence arrays coupled with enzyme-DNA biocolloid reactors and liquid chromatography-mass spectrometry.Microsome biocolloids for rapid drug metabolism and inhibition assessment by LC-MSScreening for reactive metabolites using electro-optical arrays featuring human liver cytosol and microsomal enzyme sources and DNA.Comparison of DNA-Reactive Metabolites from Nitrosamine and Styrene Using Voltammetric DNA/Microsomes Sensors.Human cyt P450 mediated metabolic toxicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) evaluated using electrochemiluminescent arrays.Synergistic metabolic toxicity screening using microsome/DNA electrochemiluminescent arrays and nanoreactors.Electrophilic adduction of ubiquitin activating enzyme E1 by N,N-diethyldithiocarbamate inhibits ubiquitin activation and is accompanied by striatal injury in the rat.Cytochrome P450s and other enzymes in drug metabolism and toxicity.
P2860
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P2860
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Elucidating mechanisms of drug-induced toxicity.
@ast
Elucidating mechanisms of drug-induced toxicity.
@en
type
label
Elucidating mechanisms of drug-induced toxicity.
@ast
Elucidating mechanisms of drug-induced toxicity.
@en
prefLabel
Elucidating mechanisms of drug-induced toxicity.
@ast
Elucidating mechanisms of drug-induced toxicity.
@en
P2860
P356
P1476
Elucidating mechanisms of drug-induced toxicity
@en
P2093
F Peter Guengerich
P2860
P2888
P304
P356
10.1038/NRD1720
P577
2005-05-01T00:00:00Z