Structure-function relationships of the viral RNA-dependent RNA polymerase: fidelity, replication speed, and initiation mechanism determined by a residue in the ribose-binding pocket
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Picornavirus genome replication: roles of precursor proteins and rate-limiting steps in oriI-dependent VPg uridylylationPoliovirus cis-acting replication element-dependent VPg Uridylylation lowers the Km of the initiating nucleoside triphosphate for viral RNA replicationHuman rhinovirus type 14 gain-of-function mutants for oriI utilization define residues of 3C(D) and 3Dpol that contribute to assembly and stability of the picornavirus VPg uridylylation complexRNA-Dependent RNA Polymerases of Picornaviruses: From the Structure to Regulatory MechanismsStructural insights into mechanisms of catalysis and inhibition in Norwalk virus polymeraseThe N-Terminus of the RNA Polymerase from Infectious Pancreatic Necrosis Virus Is the Determinant of Genome AttachmentMechanisms of viral mutationVariation in RNA virus mutation rates across host cellsEvolution of tertiary structure of viral RNA dependent polymerasesFidelity variants of RNA dependent RNA polymerases uncover an indirect, mutagenic activity of amiloride compounds.Repeated exposure to 5D9, an inhibitor of 3D polymerase, effectively limits the replication of foot-and-mouth disease virus in host cells.RNA virus population diversity, an optimum for maximal fitness and virulence.What is the role of motif D in the nucleotide incorporation catalyzed by the RNA-dependent RNA polymerase from poliovirus?Residues of the rotavirus RNA-dependent RNA polymerase template entry tunnel that mediate RNA recognition and genome replicationIsolation of fidelity variants of RNA viruses and characterization of virus mutation frequency.Highly similar structural frames link the template tunnel and NTP entry tunnel to the exterior surface in RNA-dependent RNA polymerases.Homology-Based Identification of a Mutation in the Coronavirus RNA-Dependent RNA Polymerase That Confers Resistance to Multiple MutagensCis-active RNA elements (CREs) and picornavirus RNA replicationVaccine-derived mutation in motif D of poliovirus RNA-dependent RNA polymerase lowers nucleotide incorporation fidelity.Alphavirus mutator variants present host-specific defects and attenuation in mammalian and insect modelsTherapeutically targeting RNA viruses via lethal mutagenesis.Epistatic Interactions within the Influenza A Virus Polymerase Complex Mediate Mutagen Resistance and Replication Fidelity.Amiloride is a competitive inhibitor of coxsackievirus B3 RNA polymerase.Attenuation of Foot-and-Mouth Disease Virus by Engineered Viral Polymerase Fidelity.The not-so-infinite malleability of RNA viruses: Viral and cellular determinants of RNA virus mutation rates.Triphosphate Reorientation of the Incoming Nucleotide as a Fidelity Checkpoint in Viral RNA-dependent RNA Polymerases.Determinants of RNA-dependent RNA polymerase (in)fidelity revealed by kinetic analysis of the polymerase encoded by a foot-and-mouth disease virus mutant with reduced sensitivity to ribavirin.Long-range interaction networks in the function and fidelity of poliovirus RNA-dependent RNA polymerase studied by nuclear magnetic resonance.Interrelationship between HIV-1 fitness and mutation rate.Amiloride derivatives inhibit coxsackievirus B3 RNA replication.Changes in protein domains outside the catalytic site of the bacteriophage Qβ replicase reduce the mutagenic effect of 5-azacytidine.Human rhinovirus VPg uridylylation AlphaScreen for high-throughput screening.A closed-handed affair: positive-strand RNA virus polymerases
P2860
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P2860
Structure-function relationships of the viral RNA-dependent RNA polymerase: fidelity, replication speed, and initiation mechanism determined by a residue in the ribose-binding pocket
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Structure-function relationshi ...... e in the ribose-binding pocket
@ast
Structure-function relationshi ...... e in the ribose-binding pocket
@en
type
label
Structure-function relationshi ...... e in the ribose-binding pocket
@ast
Structure-function relationshi ...... e in the ribose-binding pocket
@en
prefLabel
Structure-function relationshi ...... e in the ribose-binding pocket
@ast
Structure-function relationshi ...... e in the ribose-binding pocket
@en
P2860
P356
P1476
Structure-function relationshi ...... e in the ribose-binding pocket
@en
P2093
Victoria S Korneeva
P2860
P304
16135-16145
P356
10.1074/JBC.M610090200
P407
P577
2007-03-29T00:00:00Z