Block of C/EBP alpha function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations.
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C/EBPα Dysregulation in AML and ALLInterleukin (IL)-32β-mediated CCAAT/enhancer-binding protein α (C/EBPα) phosphorylation by protein kinase Cδ (PKCδ) abrogates the inhibitory effect of C/EBPα on IL-10 productionLEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropeniaDownstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implicationsC/EBP and DEK coordinately regulate myeloid differentiationLogical modeling of lymphoid and myeloid cell specification and transdifferentiation.EVI2B is a C/EBPα target gene required for granulocytic differentiation and functionality of hematopoietic progenitors.Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia1,25-dihydroxyvitamin D3 enhances the apoptotic activity of MDM2 antagonist nutlin-3a in acute myeloid leukemia cells expressing wild-type p53.Disruption of the C/EBPα-miR-182 balance impairs granulocytic differentiation.The biological effects of C/EBPalpha in K562 cells depend on the potency of the N-terminal regulatory region, not on specificity of the DNA binding domain.Genome-wide epigenetic analysis delineates a biologically distinct immature acute leukemia with myeloid/T-lymphoid features.Expression of the transcriptional repressor Gfi-1 is regulated by C/EBP{alpha} and is involved in its proliferation and colony formation-inhibitory effects in p210BCR/ABL-expressing cellsTriptolide inhibits IL-12/IL-23 expression in APCs via CCAAT/enhancer-binding protein alpha.Epigenomics of macrophages.MicroRNA-16 is down-regulated in mutated FLT3 expressing murine myeloid FDC-P1 cells and interacts with Pim-1.The Future of Targeting FLT3 Activation in AML.Characterization of CEBPA mutations and promoter hypermethylation in pediatric acute myeloid leukemia.C/EBPβ expression is an independent predictor of overall survival in breast cancer patients by MHCII/CD4-dependent mechanism of metastasis formation.Mapping of MN1 sequences necessary for myeloid transformation.CCAAT/enhancer-binding protein alpha (C/EBPalpha) is critical for interleukin-4 expression in response to FcepsilonRI receptor cross-linkingUnfolded protein response suppresses CEBPA by induction of calreticulin in acute myeloid leukaemia.Gene expression profiles associated with pediatric relapsed AML.Targeting cell cycle regulators in hematologic malignancies.Loss of the wild-type allele contributes to myeloid expansion and disease aggressiveness in FLT3/ITD knockin mice.Protein disulfide isomerase blocks CEBPA translation and is up-regulated during the unfolded protein response in AML.NF-κB/STAT5/miR-155 network targets PU.1 in FLT3-ITD-driven acute myeloid leukemia.Targeting MCL-1 sensitizes FLT3-ITD-positive leukemias to cytotoxic therapies.Knock-in of a FLT3/ITD mutation cooperates with a NUP98-HOXD13 fusion to generate acute myeloid leukemia in a mouse modelPhosphorylation of serine 21 modulates the proliferation inhibitory more than the differentiation inducing effects of C/EBPα in K562 cells.High levels of the BCR/ABL oncoprotein are required for the MAPK-hnRNP-E2 dependent suppression of C/EBPalpha-driven myeloid differentiationA Cell-Based High-Throughput Screening for Inducers of Myeloid Differentiation.Targeting CDK1 promotes FLT3-activated acute myeloid leukemia differentiation through C/EBPα.C/EBPalpha binds and activates the PU.1 distal enhancer to induce monocyte lineage commitment.FLT3-ITD cooperates with inv(16) to promote progression to acute myeloid leukemia.Terminal myeloid differentiation in vivo is induced by FLT3 inhibition in FLT3/ITD AML.C/EBPγ deregulation results in differentiation arrest in acute myeloid leukemia.Lenalidomide-mediated enhanced translation of C/EBPα-p30 protein up-regulates expression of the antileukemic microRNA-181a in acute myeloid leukemiaCDC25A governs proliferation and differentiation of FLT3-ITD acute myeloid leukemia.Pharmacogenetics of alkylator-associated acute myeloid leukemia.
P2860
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P2860
Block of C/EBP alpha function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Block of C/EBP alpha function ...... ith FLT3 activating mutations.
@ast
Block of C/EBP alpha function ...... ith FLT3 activating mutations.
@en
type
label
Block of C/EBP alpha function ...... ith FLT3 activating mutations.
@ast
Block of C/EBP alpha function ...... ith FLT3 activating mutations.
@en
prefLabel
Block of C/EBP alpha function ...... ith FLT3 activating mutations.
@ast
Block of C/EBP alpha function ...... ith FLT3 activating mutations.
@en
P2093
P2860
P50
P356
P1476
Block of C/EBP alpha function ...... with FLT3 activating mutations
@en
P2093
D Gary Gilliland
David W Sternberg
Donald Small
Hanna S Radomska
Marie-Hélène Delmotte
Nathalie Lokker
Neill A Giese
Roger J Davis
P2860
P304
P356
10.1084/JEM.20052242
P407
P577
2006-01-30T00:00:00Z