Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2).
about
Regulation of microglial survival and proliferation in health and diseases.Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanismsGenome-wide significant risk factors for Alzheimer's disease: role in progression to dementia due to Alzheimer's disease among subjects with mild cognitive impairmentTREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway.The endocytic pathway in microglia during health, aging and Alzheimer's disease.The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2.TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury.The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism.Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status.Rare TREM2 variants associated with Alzheimer's disease display reduced cell surface expressionApolipoprotein E metabolism and functions in brain and its role in Alzheimer's diseaseSoluble TREM2 induces inflammatory responses and enhances microglial survival.TREM2 in Neurodegenerative Diseases.The Triggering Receptor Expressed on Myeloid Cells 2: A Molecular Link of Neuroinflammation and Neurodegenerative DiseasesTREM2-Ligand Interactions in Health and Disease.A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells.The Alzheimer's disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathwayThe role of APOE on lipid homeostasis and inflammation in normal brains.Apolipoprotein E and Alzheimer's disease: the influence of apolipoprotein E on amyloid-β and other amyloidogenic proteins.Untangling Genetic Risk for Alzheimer's Disease.The lipid-sensor TREM2 aggravates disease in a model of LCMV-induced hepatitis.An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.Behavioral and transcriptomic analysis of Trem2-null mice: not all knockout mice are created equal.TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease.TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy.Microglia-Mediated Neuroprotection, TREM2, and Alzheimer's Disease: Evidence From Optical Imaging.Intracellular trafficking of TREM2 is regulated by presenilin 1.Erythrocyte efferocytosis modulates macrophages towards recovery after intracerebral hemorrhage.Erythromyeloid-Derived TREM2: A Major Determinant of Alzheimer's Disease Pathology in Down Syndrome.The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.Microglia emerge as central players in brain disease.Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model.Vps35-dependent recycling of Trem2 regulates microglial function.Neurophagy, the phagocytosis of live neurons and synapses by glia, contributes to brain development and disease.Differential contribution of microglia and monocytes in neurodegenerative diseases.Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism.A transcriptomic atlas of aged human microglia.Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models.Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation.
P2860
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P2860
Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2).
description
2015 nî lūn-bûn
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2015年の論文
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2015年学术文章
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2015年学术文章
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2015年学术文章
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2015年学术文章
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2015年学术文章
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2015年學術文章
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name
Apolipoprotein E Is a Ligand f ...... ed on Myeloid Cells 2 (TREM2).
@ast
Apolipoprotein E Is a Ligand f ...... ed on Myeloid Cells 2 (TREM2).
@en
type
label
Apolipoprotein E Is a Ligand f ...... ed on Myeloid Cells 2 (TREM2).
@ast
Apolipoprotein E Is a Ligand f ...... ed on Myeloid Cells 2 (TREM2).
@en
prefLabel
Apolipoprotein E Is a Ligand f ...... ed on Myeloid Cells 2 (TREM2).
@ast
Apolipoprotein E Is a Ligand f ...... ed on Myeloid Cells 2 (TREM2).
@en
P2093
P2860
P356
P1476
Apolipoprotein E Is a Ligand f ...... ed on Myeloid Cells 2 (TREM2).
@en
P2093
Chia-Chen Liu
Christophe Verbeeck
Honghua Zheng
John D Fryer
Meghan M Painter
Pritam Das
Silvia S Kang
Steven Younkin
P2860
P304
26043-26050
P356
10.1074/JBC.M115.679043
P407
P577
2015-09-15T00:00:00Z