Talin is required for integrin-mediated platelet function in hemostasis and thrombosis.
about
Platelet proteome analysis reveals integrin-dependent aggregation defects in patients with myelodysplastic syndromes.RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequencesKindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effectsNormal Platelet Integrin Function in Mice Lacking Hydrogen Peroxide-Induced Clone-5 (Hic-5)Novel mouse hemostasis model for real-time determination of bleeding time and hemostatic plug composition.The Structure of an Interdomain Complex That Regulates Talin ActivityThe structure of an integrin/talin complex reveals the basis of inside-out signal transduction.Structure of a double ubiquitin-like domain in the talin head: a role in integrin activationCentral Region of Talin Has a Unique Fold That Binds Vinculin and ActinA novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and functionMice carrying a complete deletion of the talin2 coding sequence are viable and fertileKindlin-2 controls bidirectional signaling of integrinsFmrp Interacts with Adar and Regulates RNA Editing, Synaptic Density and Locomotor Activity in ZebrafishPhosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces.The kinetics of αIIbβ3 activation determines the size and stability of thrombi in mice: implications for antiplatelet therapy.In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling.Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation.A directional switch of integrin signalling and a new anti-thrombotic strategy.Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo.Podocyte-associated talin1 is critical for glomerular filtration barrier maintenance.Platelet actin nodules are podosome-like structures dependent on Wiskott-Aldrich syndrome protein and ARP2/3 complex.The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend.Transgenic, inducible RNAi in megakaryocytes and platelets in mice.New insights into the versatile roles of platelet FlnA.Integrin alphaIIbbeta3 activation in Chinese hamster ovary cells and platelets increases clustering rather than affinityNew PI(4,5)P2- and membrane proximal integrin-binding motifs in the talin head control beta3-integrin clustering.Recreation of the terminal events in physiological integrin activation.Structural and mechanical functions of integrins.Control of cell adhesion dynamics by Rap1 signaling.Significance of talin in cancer progression and metastasis.Neutrophil adhesion and activation under flow.Analysis of covalent modifications of proteins by oxidized phospholipids using a novel method of peptide enrichment.Integrin αII b tail distal of GFFKR participates in inside-out αII b β3 activation.Chemokine arrest signals to leukocyte integrins trigger bi-directional-occupancy of individual heterodimers by extracellular and cytoplasmic ligandsTalins and kindlins: partners in integrin-mediated adhesion.Migfilin and filamin as regulators of integrin activation in endothelial cells and neutrophils.The final steps of integrin activation: the end gameTyrosine phosphorylation of integrin beta3 regulates kindlin-2 binding and integrin activation.Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1.New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2.
P2860
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P2860
Talin is required for integrin-mediated platelet function in hemostasis and thrombosis.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Talin is required for integrin-mediated platelet function in hemostasis and thrombosis.
@ast
Talin is required for integrin-mediated platelet function in hemostasis and thrombosis.
@en
type
label
Talin is required for integrin-mediated platelet function in hemostasis and thrombosis.
@ast
Talin is required for integrin-mediated platelet function in hemostasis and thrombosis.
@en
prefLabel
Talin is required for integrin-mediated platelet function in hemostasis and thrombosis.
@ast
Talin is required for integrin-mediated platelet function in hemostasis and thrombosis.
@en
P2093
P2860
P356
P1476
Talin is required for integrin-mediated platelet function in hemostasis and thrombosis.
@en
P2093
Brian G Petrich
David R Critchley
Mark H Ginsberg
Patrizia Marchese
Rachel A M Weichert
Radek C Skoda
Ralph Tiedt
Saskia Spiess
Susan J Monkley
P2860
P304
P356
10.1084/JEM.20071800
P407
P577
2007-12-17T00:00:00Z