Predicting QT prolongation in humans during early drug development using hERG inhibition and an anaesthetized guinea-pig model.
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Update on the evaluation of a new drug for effects on cardiac repolarization in humans: issues in early drug developmentIonic mechanisms underlying the negative chronotropic action of propofol on sinoatrial node automaticity in guinea pig heartEpigenetic therapy for Friedreich ataxiaThe electro-mechanical window in anaesthetized guinea pigs: a new marker in screening for Torsade de Pointes risk.Wild type and K897T polymorphisms of the hERG gene: modeling the APD in Caucasians.Age and gender dependent heart rate circadian model development and performance verification on the proarrhythmic drug case study.Anti-addiction drug ibogaine inhibits voltage-gated ionic currents: a study to assess the drug's cardiac ion channel profileExploratory safety pharmacology: a new safety paradigm to de-risk drug candidates prior to selection for regulatory science investigations.Supplemental studies for cardiovascular risk assessment in safety pharmacology: a critical overview.Evidence for the hERG Liability of Antihistamines, Antipsychotics, and Anti-Infective Agents: A Systematic Literature Review From the ARITMO Project.Development and Comparison of hERG Blocker Classifiers: Assessment on Different Datasets Yields Markedly Different Results.The novel benzimidazole derivative BRP-7 inhibits leukotriene biosynthesis in vitro and in vivo by targeting 5-lipoxygenase-activating protein (FLAP).Bridging Functional and Structural Cardiotoxicity Assays Using Human Embryonic Stem Cell-Derived Cardiomyocytes for a More Comprehensive Risk Assessment.Sudden cardiac and sudden unexpected death related to antipsychotics: A meta-analysis of observational studies.Development of (6 R)-2-Nitro-6-[4-(trifluoromethoxy)phenoxy]-6,7-dihydro-5 H-imidazo[2,1- b][1,3]oxazine (DNDI-8219): A New Lead for Visceral Leishmaniasis.Assessment of temperature-induced hERG channel blockade variation by drugs.
P2860
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P2860
Predicting QT prolongation in humans during early drug development using hERG inhibition and an anaesthetized guinea-pig model.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Predicting QT prolongation in ...... naesthetized guinea-pig model.
@ast
Predicting QT prolongation in ...... naesthetized guinea-pig model.
@en
type
label
Predicting QT prolongation in ...... naesthetized guinea-pig model.
@ast
Predicting QT prolongation in ...... naesthetized guinea-pig model.
@en
prefLabel
Predicting QT prolongation in ...... naesthetized guinea-pig model.
@ast
Predicting QT prolongation in ...... naesthetized guinea-pig model.
@en
P2093
P2860
P356
P1476
Predicting QT prolongation in ...... naesthetized guinea-pig model.
@en
P2093
D C Cooper
D L Anderson
J D Becherer
K I MacKenzie
M A Hashim
M L Bergquist
M S McIntyre
P2860
P304
P356
10.1038/BJP.2008.267
P407
P577
2008-06-30T00:00:00Z