High-throughput screening assays for the identification of chemical probes.
about
Identification of direct protein targets of small moleculesBright ideas for chemical biologyCan Invalid Bioactives Undermine Natural Product-Based Drug Discovery?A Role for Fragment-Based Drug Design in Developing Novel Lead Compounds for Central Nervous System TargetsHit identification and optimization in virtual screening: practical recommendations based on a critical literature analysisPhysicochemical characterization of a thermostable alcohol dehydrogenase from Pyrobaculum aerophilumComprehensive Mechanistic Analysis of Hits from High-Throughput and Docking Screens against β-LactamaseTitration-Based Screening for Evaluation of Natural Product Extracts: Identification of an Aspulvinone Family of Luciferase InhibitorsCell-Based Assay Design for High-Content Screening of Drug CandidatesHigh-throughput screening for small-molecule inhibitors of plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonaseRational methods for the selection of diverse screening compoundsIdentification of potent chemotypes targeting Leishmania major using a high-throughput, low-stringency, computationally enhanced, small molecule screenQuantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascadeIdentification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1Bioluminescence-based high-throughput screen identifies pharmacological agents that target neurotransmitter signaling in small cell lung carcinomaUsing nuclear receptor activity to stratify hepatocarcinogensA high throughput screen identifies chemical modulators of the laminin-induced clustering of dystroglycan and aquaporin-4 in primary astrocytesDifferential mitochondrial toxicity screening and multi-parametric data analysisDiverse small molecule inhibitors of human apurinic/apyrimidinic endonuclease APE1 identified from a screen of a large public collectionInhibitors of the influenza A virus M2 proton channel discovered using a high-throughput yeast growth restoration assayProfile of the GSK published protein kinase inhibitor set across ATP-dependent and-independent luciferases: implications for reporter-gene assaysTargeting an Essential GTPase Obg for the Development of Broad-Spectrum AntibioticsThe state of the art of odorant receptor deorphanization: a report from the orphanageOpen access high throughput drug discovery in the public domain: a Mount Everest in the making.High-throughput screening in primary neuronsFluorescence-based assay as a new screening tool for toxic chemicalsImproving drug discovery with high-content phenotypic screens by systematic selection of reporter cell linesHigh-throughput compatible fluorescence resonance energy transfer-based assay to identify small molecule inhibitors of AMSH deubiquitinase activityEpigenetic assays for chemical biology and drug discovery.Breath biomarkers in toxicology.Development of a fluorogenic sensor for activated Cdc42.Paradigm shift in toxicity testing and modeling.Considerations for designing chemical screening strategies in plant biology.Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes.Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol proteaseInteraction-dependent PCR: identification of ligand-target pairs from libraries of ligands and libraries of targets in a single solution-phase experiment.A high-throughput screening assay for determining cellular levels of total tau protein.Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput screens of NFkappaB activation.Dual-fluorophore quantitative high-throughput screen for inhibitors of BRCT-phosphoprotein interactionA specific mechanism for nonspecific activation in reporter-gene assays
P2860
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P2860
High-throughput screening assays for the identification of chemical probes.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
High-throughput screening assays for the identification of chemical probes.
@en
type
label
High-throughput screening assays for the identification of chemical probes.
@en
prefLabel
High-throughput screening assays for the identification of chemical probes.
@en
P2093
P50
P356
P1476
High-throughput screening assays for the identification of chemical probes.
@en
P2093
Douglas S Auld
James Inglese
Menghang Xia
Ronald L Johnson
P2888
P304
P356
10.1038/NCHEMBIO.2007.17
P577
2007-08-01T00:00:00Z