A specific mechanism for nonspecific activation in reporter-gene assays - Wikidata - thesis-toulmin - TriplyDB

A specific mechanism for nonspecific activation in reporter-gene assays

A specific mechanism for nonspecific activation in reporter-gene assays

http://www.wikidata.org/entity/Q33347807

about

Harmine, a natural beta-carboline alkaloid, upregulates astroglial glutamate transporter expression Recent developments in the use of differential scanning fluorometry in protein and small molecule discovery and characterization Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124 Firefly Luciferase in Chemical Biology: A Compendium of Inhibitors, Mechanistic Evaluation of Chemotypes, and Suggested Use As a Reporter Titration-Based Screening for Evaluation of Natural Product Extracts: Identification of an Aspulvinone Family of Luciferase Inhibitors Small-molecule inhibitor leads of ribosome-inactivating proteins developed using the doorstop approach Drug discovery for Duchenne muscular dystrophy via utrophin promoter activation screening Profile of the GSK published protein kinase inhibitor set across ATP-dependent and-independent luciferases: implications for reporter-gene assays A cell-based high-throughput screen for novel chemical inducers of fetal hemoglobin for treatment of hemoglobinopathies Mixture Effects of Estrogenic Pesticides at the Human Estrogen Receptor α and β Perspectives on validation of high-throughput assays supporting 21st century toxicity testing A basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolution Structure-activity relationships and cancer-cell selective toxicity of novel inhibitors of glioma-associated oncogene homologue 1 (Gli1) mediated transcription.The pilot phase of the NIH Chemical Genomics Center.Improved assays for determining the cytosolic access of peptides, proteins, and their mimetics.Apparent activity in high-throughput screening: origins of compound-dependent assay interference Development and Validation of a Computational Model for Androgen Receptor Activity Exploratory analysis of kinetic solubility measurements of a small molecule library Illuminating insights into firefly luciferase and other bioluminescent reporters used in chemical biology High-throughput screening identifies aclacinomycin as a radiosensitizer of EGFR-mutant non-small cell lung cancer Boosting innate immunity: development and validation of a cell-based screening assay to identify LL-37 inducers.Discovery, synthesis, and biological evaluation of novel SMN protein modulators.PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome.Integrated Model of Chemical Perturbations of a Biological Pathway Using 18 In Vitro High-Throughput Screening Assays for the Estrogen Receptor.A novel quantitative high-throughput screen identifies drugs that both activate SUMO conjugation via the inhibition of microRNAs 182 and 183 and facilitate neuroprotection in a model of oxygen and glucose deprivation.Selecting, Acquiring, and Using Small Molecule Libraries for High-Throughput Screening.Identification of drug modulators targeting gene-dosage disease CMT1A.Mechanism of PTC124 activity in cell-based luciferase assays of nonsense codon suppression.Bioluminescence: a versatile technique for imaging cellular and molecular features.Exemplification of the challenges associated with utilising fluorescence intensity based assays in discovery.Polymer nanoassemblies with hydrophobic pendant groups in the core induce false positive siRNA transfection in luciferase reporter assays.Quantitative High-Throughput Screening Using a Coincidence Reporter Biocircuit.A Luciferase Reporter Gene System for High-Throughput Screening of γ-Globin Gene Activators.Small molecule screening identifies regulators of the transcription factor ΔFosB Plasma protein binding of luciferase substrates influences sensitivity and accuracy of bioluminescence imaging.Computational analysis and predictive modeling of small molecule modulators of microRNA Prediction of luciferase inhibitors by the high-performance MIEC-GBDT approach based on interaction energetic patterns.Bioluminescence Imaging of Spheroids for High-throughput Longitudinal Studies on 3D Cell Culture Models.A detective story in drug discovery: elucidation of a screening artifact reveals polymeric carboxylic acids as potent inhibitors of RNA polymerase.Gene Promoters and Transcription Control Regions as Therapeutic Targets

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P2860

A specific mechanism for nonspecific activation in reporter-gene assays

http://www.wikidata.org/entity/Q33347807

description

2008 nî lūn-bûn

@nan

2008 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2008年の論文

@ja

2008年論文

@yue

2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

name

A specific mechanism for nonspecific activation in reporter-gene assays

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A specific mechanism for nonspecific activation in reporter-gene assays

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type

label

A specific mechanism for nonspecific activation in reporter-gene assays

@ast

A specific mechanism for nonspecific activation in reporter-gene assays

@en

prefLabel

A specific mechanism for nonspecific activation in reporter-gene assays

@ast

A specific mechanism for nonspecific activation in reporter-gene assays

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ACS Chemical Biology

P1476

A specific mechanism for nonspecific activation in reporter-gene assays

@en

P2093

Dac-Trung Nguyen

http://www.w3.org/2001/XMLSchema#string

Douglas S Auld

http://www.w3.org/2001/XMLSchema#string

James Inglese

http://www.w3.org/2001/XMLSchema#string

Natasha Thorne

http://www.w3.org/2001/XMLSchema#string

P2860

The mechanism by which cycloheximide and related glutarimide antibiotics inhibit peptide synthesis on reticulocyte ribosomes

Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries.

Bioluminescent assays for high-throughput screening.

Fluorescence spectroscopic profiling of compound libraries.

Characterization of chemical libraries for luciferase inhibitory activity.

High-throughput screening assays for the identification of chemical probes.

The role of mRNA and protein stability in gene expression.

Development of a destabilized firefly luciferase enzyme for measurement of gene expression.

Modulation of firefly luciferase stability and impact on studies of gene regulation.

Identification of ligand binding by protein stabilization: comparison of ATLAS with biophysical and enzymatic methods.

P304

463-470

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scholarly article

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10.1021/CB8000793

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8

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3

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2008-07-01T00:00:00Z

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5261917

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18590332

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2729322

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