Enhancement of methotrexate resistance and dihydrofolate reductase gene amplification by treatment of mouse 3T6 cells with hydroxyurea
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Persistent nicotine treatment potentiates amplification of the dihydrofolate reductase gene in rat lung epithelial cells as a consequence of Ras activationGene amplification in a p53-deficient cell line requires cell cycle progression under conditions that generate DNA breakagePosition effects on the timing of replication of chromosomally integrated simian virus 40 molecules in Chinese hamster cells.Hydroxyurea-resistant vaccinia virus: overproduction of ribonucleotide reductaseStructure and regulated expression of genes encoding fructose biphosphate aldolase in Trypanosoma brucei.Niche expansion in bacteria: can infectious gene exchange affect the rate of evolution?Evaluating quantitative variation in the genome of Zea mays.Herpes simplex virus ocular infections: current concepts of acute, latent and reactivated diseaseDifferences in the rates of gene amplification in nontumorigenic and tumorigenic cell lines as measured by Luria-Delbrück fluctuation analysis.Identification of methotrexate transport deficiency in mammalian cells using fluoresceinated methotrexate and flow cytometryFrequencies of independent and simultaneous selection of Chinese hamster cells for methotrexate and doxorubicin (adriamycin) resistancePolyglutamation of methotrexate. Is methotrexate a prodrug?Induction of terminal differentiation in human K562 erythroleukemia cells by arabinofuranosylcytosine.Toxicity of folic acid analogs in cultured human cells: a microtiter assay for the analysis of drug competition.Replication fork integrity and intra-S phase checkpoint suppress gene amplification.Overreplication and recombination of DNA in higher eukaryotes: potential consequences and biological implications.Temporal order of replication of Xenopus laevis 5S ribosomal RNA genes in somatic cells.Evidence that the Bacillus subtilis pyrimidine regulatory protein PyrR acts by binding to pyr mRNA at three sites in vivo.Early replication and expression of oocyte-type 5S RNA genes in a Xenopus somatic cell line carrying a translocation.Intrastrand annealing leads to the formation of a large DNA palindrome and determines the boundaries of genomic amplification in human cancerFifth Gordon Hamilton-Fairley memorial lecture. Methotrexate resistance and gene amplification: an experimental model for the generation of cellular heterogeneityA study of chromosomal changes associated with amplified dihydrofolate reductase genes in rat hepatoma cells and their dedifferentiated variantsAberrant expression of an amplified c-myb oncogene in two cell lines from a colon carcinoma.Induction of circles of heterogeneous sizes in carcinogen-treated cells: two-dimensional gel analysis of circular DNA molecules.Random-choice replication of extrachromosomal bovine papillomavirus (BPV) molecules in heterogeneous, clonally derived BPV-infected cell lines.Autonomously replicating episomes contain mdr1 genes in a multidrug-resistant human cell line.Replication timing of DNA sequences associated with human centromeres and telomeresEffect of cycloheximide on development of methotrexate resistance of Chinese hamster ovary cells treated with inhibitors of DNA synthesis.Herpes simplex virus induces the replication of foreign DNA.Herpes simplex virus virion host shutoff functionA 12-O-tetradecanoylphorbol-13-acetate (TPA)-nonproliferative variant of 3T3 cells is resistant to TPA-enhanced gene amplification.Transient inhibition of DNA synthesis results in increased dihydrofolate reductase synthesis and subsequent increased DNA content per cellDifferential order of replication of Xenopus laevis 5S RNA genes.UV radiation facilitates methotrexate resistance and amplification of the dihydrofolate reductase gene in cultured 3T6 mouse cells.Redox regulation of multidrug resistance in cancer chemotherapy: molecular mechanisms and therapeutic opportunitiesOncogene expression in primary myelodysplasia: correlation with haematological, karyotypic, and clinical progression.Elimination of extrachromosomally amplified MYC genes from human tumor cells reduces their tumorigenicity.Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells.Profiling ribonucleotide and deoxyribonucleotide pools perturbed by gemcitabine in human non-small cell lung cancer cells.Loss of unstably amplified dihydrofolate reductase genes from mouse cells is greatly accelerated by hydroxyurea
P2860
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P2860
Enhancement of methotrexate resistance and dihydrofolate reductase gene amplification by treatment of mouse 3T6 cells with hydroxyurea
description
1983 nî lūn-bûn
@nan
1983年の論文
@ja
1983年論文
@yue
1983年論文
@zh-hant
1983年論文
@zh-hk
1983年論文
@zh-mo
1983年論文
@zh-tw
1983年论文
@wuu
1983年论文
@zh
1983年论文
@zh-cn
name
Enhancement of methotrexate re ...... use 3T6 cells with hydroxyurea
@en
type
label
Enhancement of methotrexate re ...... use 3T6 cells with hydroxyurea
@en
prefLabel
Enhancement of methotrexate re ...... use 3T6 cells with hydroxyurea
@en
P2093
P2860
P356
P1476
Enhancement of methotrexate re ...... use 3T6 cells with hydroxyurea
@en
P2093
P2860
P304
P356
10.1128/MCB.3.6.1097
P407
P577
1983-06-01T00:00:00Z