The interactome of the amyloid beta precursor protein family members is shaped by phosphorylation of their intracellular domains.
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JNK Signaling: Regulation and Functions Based on Complex Protein-Protein PartnershipsAPP processing in Alzheimer's diseaseAPP is cleaved by Bace1 in pre-synaptic vesicles and establishes a pre-synaptic interactome, via its intracellular domain, with molecular complexes that regulate pre-synaptic vesicles functionsUncovering molecular biomarkers that correlate cognitive decline with the changes of hippocampus' gene expression profiles in Alzheimer's disease.A new molecular explanation for age-related neurodegeneration: the Tyr682 residue of amyloid precursor proteinTyr(682) in the intracellular domain of APP regulates amyloidogenic APP processing in vivo.The Intersection of NGF/TrkA Signaling and Amyloid Precursor Protein Processing in Alzheimer's Disease NeuropathologyNovel adaptors of amyloid precursor protein intracellular domain and their functional implications.An intracellular threonine of amyloid-β precursor protein mediates synaptic plasticity deficits and memory loss.A single tyrosine residue in the amyloid precursor protein intracellular domain is essential for developmental function.The intracellular threonine of amyloid precursor protein that is essential for docking of Pin1 is dispensable for developmental function.Visualization and quantification of APP intracellular domain-mediated nuclear signaling by bimolecular fluorescence complementation.Y682G Mutation of Amyloid Precursor Protein Promotes Endo-Lysosomal Dysfunction by Disrupting APP-SorLA Interaction.Amyloid-β precursor protein: Multiple fragments, numerous transport routes and mechanismsAPP is phosphorylated by TrkA and regulates NGF/TrkA signaling.Lessons from a Rare Familial Dementia: Amyloid and Beyond.Tyr682 in the Aβ-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance.Appoptosin is a novel pro-apoptotic protein and mediates cell death in neurodegeneration.Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer's disease.Topologically Diverse Human Membrane Proteins Partition to Liquid-Disordered Domains in Phase-Separated Lipid Vesicles.APP Receptor? To Be or Not To Be.NGF controls APP cleavage by downregulating APP phosphorylation at Thr668: relevance for Alzheimer's disease.Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents.Mediators of tau phosphorylation in the pathogenesis of Alzheimer's disease.Tau protein modifications and interactions: their role in function and dysfunction.Direct binding of cholesterol to the amyloid precursor protein: An important interaction in lipid-Alzheimer's disease relationships?Biology and pathophysiology of the amyloid precursor protein.Intrinsically unstructured proteins and neurodegenerative diseases: conformational promiscuity at its best.APP physiological and pathophysiological functions: insights from animal models.Functions of the APP gene family in the nervous system: insights from mouse models.Relationships between the amyloid precursor protein and its various proteolytic fragments and neuronal systems.Numb and Alzheimer's disease: the current pictureImpact of bilayer lipid composition on the structure and topology of the transmembrane amyloid precursor C99 proteinNot just amyloid: physiological functions of the amyloid precursor protein family.APP Protein Family Signaling at the Synapse: Insights from Intracellular APP-Binding Proteins.Protein Phosphorylation is a Key Mechanism in Alzheimer's Disease.Multisite tyrosine phosphorylation of the N-terminus of Mint1/X11α by Src kinase regulates the trafficking of amyloid precursor proteinAmyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and NeurodegenerationProtein kinase C and rho activated coiled coil protein kinase 2 (ROCK2) modulate Alzheimer's APP metabolism and phosphorylation of the Vps10-domain protein, SorL1.Using Multi-Scale Genetic, Neuroimaging and Clinical Data for Predicting Alzheimer's Disease and Reconstruction of Relevant Biological Mechanisms
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The interactome of the amyloid beta precursor protein family members is shaped by phosphorylation of their intracellular domains.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 14 July 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The interactome of the amyloid ...... f their intracellular domains.
@en
The interactome of the amyloid ...... f their intracellular domains.
@nl
type
label
The interactome of the amyloid ...... f their intracellular domains.
@en
The interactome of the amyloid ...... f their intracellular domains.
@nl
prefLabel
The interactome of the amyloid ...... f their intracellular domains.
@en
The interactome of the amyloid ...... f their intracellular domains.
@nl
P2093
P2860
P356
P1476
The interactome of the amyloid ...... f their intracellular domains.
@en
P2093
Dawang Zhou
Luciano D'Adamio
Robert Tamayev
P2860
P2888
P356
10.1186/1750-1326-4-28
P577
2009-07-14T00:00:00Z
P5875
P6179
1047562055