Use of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasis
about
Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252aBiology of MET: a double life between normal tissue repair and tumor progressionNon-redundant role of Shc in Erk activation by cytoskeletal reorganizationMet receptor tyrosine kinase signals through a cortactin-Gab1 scaffold complex, to mediate invadopodiaGrb2 regulation of the actin-based cytoskeleton is required for ligand-independent EGF receptor-mediated oncogenesis.Identification of Shc Src homology 2 domain-binding peptoid-peptide hybridsGab1 is required for cell cycle transition, cell proliferation, and transformation induced by an oncogenic met receptor.Met receptor-induced Grb2 or Shc signals both promote transformation of intestinal epithelial cells, albeit they are required for distinct oncogenic functions.The Shc adaptor protein is critical for VEGF induction by Met/HGF and ErbB2 receptors and for early onset of tumor angiogenesisFrom Tpr-Met to Met, tumorigenesis and tubes.Development of Grb2 SH2 Domain Signaling Antagonists: A Potential New Class of Antiproliferative AgentsThe interactome of the amyloid beta precursor protein family members is shaped by phosphorylation of their intracellular domains.Specific Grb2-mediated interactions regulate clathrin-dependent endocytosis of the cMet-tyrosine kinase.Distinct involvement of the Gab1 and Grb2 adaptor proteins in signal transduction by the related receptor tyrosine kinases RON and MET.Oncogenic engagement of the Met receptor is sufficient to evoke angiogenic, tumorigenic, and metastatic activities in rat intestinal epithelial cells.Amyloid precursor protein modulates ERK-1 and -2 signaling.Uncoupling ligand-dependent and -independent mechanisms for mitogen-activated protein kinase activation by the murine Ron receptor tyrosine kinase.Grb2-independent recruitment of Gab1 requires the C-terminal lobe and structural integrity of the Met receptor kinase domain.Non-canonical dynamic mechanisms of interaction between the p66Shc protein and Met receptorSublethal heat treatment promotes epithelial-mesenchymal transition and enhances the malignant potential of hepatocellular carcinoma.Insights into the Shc Family of Adaptor Proteins.
P2860
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P2860
Use of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasis
description
2002 nî lūn-bûn
@nan
2002 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մարտին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
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name
Use of signal specific recepto ...... transformation and metastasis
@ast
Use of signal specific recepto ...... transformation and metastasis
@en
Use of signal specific recepto ...... transformation and metastasis
@en-gb
Use of signal specific recepto ...... transformation and metastasis
@nl
type
label
Use of signal specific recepto ...... transformation and metastasis
@ast
Use of signal specific recepto ...... transformation and metastasis
@en
Use of signal specific recepto ...... transformation and metastasis
@en-gb
Use of signal specific recepto ...... transformation and metastasis
@nl
prefLabel
Use of signal specific recepto ...... transformation and metastasis
@ast
Use of signal specific recepto ...... transformation and metastasis
@en
Use of signal specific recepto ...... transformation and metastasis
@en-gb
Use of signal specific recepto ...... transformation and metastasis
@nl
P2093
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Use of signal specific recepto ...... transformation and metastasis
@en
P2093
Alexander Palazzo
Caroline Saucier
Monica A Naujokas
Morag Park
Richard Kremer
Vasilios Papavasiliou
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P2888
P304
P3181
P356
10.1038/SJ.ONC.1205261
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P577
2002-03-14T00:00:00Z
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P6179
1031681974