Clostridium difficile toxin B-induced necrosis is mediated by the host epithelial cell NADPH oxidase complex. - Wikidata - thesis-toulmin - TriplyDB

Clostridium difficile toxin B-induced necrosis is mediated by the host epithelial cell NADPH oxidase complex.

Clostridium difficile toxin B-induced necrosis is mediated by the host epithelial cell NADPH oxidase complex.

http://www.wikidata.org/entity/Q37319468

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Clostridium difficile Toxins A and B: Insights into Pathogenic Properties and Extraintestinal Effects Reactive Oxygen Species as Additional Determinants for Cytotoxicity of Clostridium difficile Toxins A and B The Role of Rho GTPases in Toxicity of Clostridium difficile Toxins Utility of Clostridium difficile toxin B for inducing anti-tumor immunity.Translocation domain mutations affecting cellular toxicity identify the Clostridium difficile toxin B pore.Critical roles of Clostridium difficile toxin B enzymatic activities in pathogenesis.Exposure of neutralizing epitopes in the carboxyl-terminal domain of TcdB is altered by a proximal hypervariable region.Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B.Defining the Roles of TcdA and TcdB in Localized Gastrointestinal Disease, Systemic Organ Damage, and the Host Response during Clostridium difficile Infections Identification of an epithelial cell receptor responsible for Clostridium difficile TcdB-induced cytotoxicity.Clostridium difficile Toxin A Undergoes Clathrin-Independent, PACSIN2-Dependent Endocytosis The NADase-Negative Variant of the Streptococcus pyogenes Toxin NAD⁺ Glycohydrolase Induces JNK1-Mediated Programmed Cellular Necrosis.Cloning and variation of ground state intestinal stem cells BPA-toxicity via superoxide anion overload and a deficit in β-catenin signaling in human bone mesenchymal stem cells.Vaccines against Clostridium difficile.Cytotoxin-induced NADPH oxides activation: roles in regulation of cell death.Glucosyltransferase-dependent and -independent effects of TcdB on the proteome of HEp-2 cells.Bacterial glycosyltransferase toxins.Investigation of the Cross-talk Mechanism in Caco-2 Cells during Clostridium difficile Infection through Genetic-and-Epigenetic Interspecies Networks: Big Data Mining and Genome-Wide Identification.Phase Variation of Clostridium difficile Virulence Factors.Novel therapeutic strategies for Clostridium difficile infections.ROS in gastrointestinal inflammation: Rescue Or Sabotage?Pathogenic effects of glucosyltransferase from Clostridium difficile toxins.Pyknotic cell death induced by Clostridium difficile TcdB: chromatin condensation and nuclear blister are induced independently of the glucosyltransferase activity.The emerging metabolic view of Clostridium difficile pathogenesis.Clostridium difficile toxins A and B: Receptors, pores, and translocation into cells.A small-molecule antivirulence agent for treating Clostridium difficile infection.Effective Sequestration of Clostridium difficile Protein Toxins by Calcium Aluminosilicate Clostridium difficile Toxins TcdA and TcdB Cause Colonic Tissue Damage by Distinct Mechanisms.Control of Clostridium difficile Infection by Defined Microbial Communities.Enteric glial cells counteract Clostridium difficile Toxin B through a NADPH oxidase/ROS/JNK/caspase-3 axis, without involving mitochondrial pathways.NADPH oxidase inhibitor, diphenyleneiodonium prevents necroptosis in HK-2 cells.Human neutrophils are activated by a peptide fragment of Clostridium difficile toxin B presumably via formyl peptide receptor.The role of toxins in Clostridium difficile infection.Functional defects in Clostridium difficile TcdB toxin uptake identify CSPG4 receptor-binding determinants.Clostridium difficile toxin B induces autophagic cell death in colonocytes.Receptors and Binding Structures for Clostridium difficile Toxins A and B.

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Clostridium difficile toxin B-induced necrosis is mediated by the host epithelial cell NADPH oxidase complex.

http://www.wikidata.org/entity/Q37319468

description

article científic

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articolo scientifico

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bilimsel makale

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scientific article published on 28 October 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Clostridium difficile toxin B- ...... al cell NADPH oxidase complex.

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Clostridium difficile toxin B- ...... al cell NADPH oxidase complex.

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type

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Clostridium difficile toxin B- ...... al cell NADPH oxidase complex.

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Clostridium difficile toxin B- ...... al cell NADPH oxidase complex.

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prefLabel

Clostridium difficile toxin B- ...... al cell NADPH oxidase complex.

@en

Clostridium difficile toxin B- ...... al cell NADPH oxidase complex.

@nl

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PNAS.1313658110

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Proceedings of the National Academy of Sciences of the United States of America

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Clostridium difficile toxin B- ...... al cell NADPH oxidase complex.

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James R Goldenring

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Jeffrey L Franklin

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Lynne A Lapierre

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Melissa A Farrow

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Nicole M Chumbler

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Stacey A Rutherford

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P2860

Clostridial glucosylating toxins enter cells via clathrin-mediated endocytosis

Cell transformation by the superoxide-generating oxidase Mox1

Clostridium difficile toxins: mechanism of action and role in disease.

Toxins A and B from Clostridium difficile differ with respect to enzymatic potencies, cellular substrate specificities, and surface binding to cultured cells

Host S-nitrosylation inhibits clostridial small molecule-activated glucosylating toxins

Toxin B is essential for virulence of Clostridium difficile

Differential effects of Clostridium difficile toxins on tissue-cultured cells

Biochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular system

Clostridium difficile Toxin B causes epithelial cell necrosis through an autoprocessing-independent mechanism

Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase

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18674-18679

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scholarly article

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10.1073/PNAS.1313658110

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46

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110

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Dana Borden Lacy

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2013-10-28T00:00:00Z

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258117565

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24167244

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Clostridium difficile

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3831945

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