Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system. - Wikidata - thesis-toulmin - TriplyDB

Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system.

Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system.

http://www.wikidata.org/entity/Q37528540

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Early etiology of Alzheimer's disease: tipping the balance toward autophagy or endosomal dysfunction?Sorting through the roles of beclin 1 in microglia and neurodegeneration Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis Tau phosphorylation regulates the interaction between BIN1's SH3 domain and Tau's proline-rich domain A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of β-amyloid production.Protein kinase D1/2 is involved in the maturation of multivesicular bodies and secretion of exosomes in T and B lymphocytes Isolating pathogenic mechanisms embedded within the hippocampal circuit through regional vulnerability.Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism.GA binding protein augments autophagy via transcriptional activation of BECN1-PIK3C3 complex genes Hyperleucinemia causes hippocampal retromer deficiency linking diabetes to Alzheimer's disease.Caffeine Blocks HIV-1 Tat-Induced Amyloid Beta Production and Tau Phosphorylation.Lipids under stress--a lipidomic approach for the study of mood disorders.Cathepsin L Mediates the Degradation of Novel APP C-Terminal Fragments.Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing Aβ Generation and Amyloid Plaque Pathogenesis.Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer's disease pathogenesis.Autophagy and endosomal trafficking inhibition by Vibrio cholerae MARTX toxin phosphatidylinositol-3-phosphate-specific phospholipase A1 activity Physiological and pathophysiological roles for phospholipase D.Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer's disease.ESCRT-0 dysfunction compromises autophagic degradation of protein aggregates and facilitates ER stress-mediated neurodegeneration via apoptotic and necroptotic pathways.APP Receptor? To Be or Not To Be.A novel contribution of spvB to pathogenesis of Salmonella Typhimurium by inhibiting autophagy in host cells.Role of Endolysosomes in Skeletal Muscle Pathology Observed in a Cholesterol-Fed Rabbit Model of Alzheimer's Disease.The Endosome-associated Deubiquitinating Enzyme USP8 Regulates BACE1 Enzyme Ubiquitination and Degradation.SNX27 and SORLA Interact to Reduce Amyloidogenic Subcellular Distribution and Processing of Amyloid Precursor Protein.Classes of phosphoinositide 3-kinases at a glance.Increased PLEKHO1 within osteoblasts suppresses Smad-dependent BMP signaling to inhibit bone formation during aging.Amphiphysin 2 (BIN1) in physiology and diseases.An overview of inborn errors of complex lipid biosynthesis and remodelling.Role of endolysosomes and cholesterol in the pathogenesis of Alzheimer's disease: Insights into why statins might not provide clinical benefit.PI3K-C2α: One enzyme for two products coupling vesicle trafficking and signal transduction.The Role of Retromer in Alzheimer's Disease.Study of Exosomes Shed New Light on Physiology of Amyloidogenesis.The fine-tuning of proteolytic pathways in Alzheimer's disease.ESCRTs regulate amyloid precursor protein sorting in multivesicular bodies and intracellular amyloid-β accumulation.Amyloid precursor protein processing and bioenergetics.Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing.Endo-lysosomal and autophagic dysfunction: a driving factor in Alzheimer's disease?The spread of prion-like proteins by lysosomes and tunneling nanotubes: Implications for neurodegenerative diseases.Early-Onset Alzheimer Disease and Candidate Risk Genes Involved in Endolysosomal Transport.

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Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system.

http://www.wikidata.org/entity/Q37528540

description

article científic

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article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

@tr

scientific article published on January 2013

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Phosphatidylinositol-3-phospha ...... through the endosomal system.

@en

Phosphatidylinositol-3-phospha ...... through the endosomal system.

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type

label

Phosphatidylinositol-3-phospha ...... through the endosomal system.

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Phosphatidylinositol-3-phospha ...... through the endosomal system.

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prefLabel

Phosphatidylinositol-3-phospha ...... through the endosomal system.

@en

Phosphatidylinositol-3-phospha ...... through the endosomal system.

@nl

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Nature Communications

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Phosphatidylinositol-3-phospha ...... through the endosomal system.

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Brian D McCabe

http://www.w3.org/2001/XMLSchema#string

Christopher Vetanovetz

http://www.w3.org/2001/XMLSchema#string

Claudia Dall'Armi

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Etienne Morel

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Gilbert Di Paolo

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Kimberly S Point Du Jour

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Rebecca L Williamson

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Robin B Chan

http://www.w3.org/2001/XMLSchema#string

Sabrina Simoes

http://www.w3.org/2001/XMLSchema#string

Scott A Small

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P2860

Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex

Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies

Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells

Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

Inhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid beta protein.

Class III phosphatidylinositol 3-kinase and its catalytic product PtdIns3P in regulation of endocytic membrane traffic

Phosphoinositides in cell regulation and membrane dynamics

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

The p11/S100A10 light chain of annexin A2 is dispensable for annexin A2 association to endosomes and functions in endosomal transport

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2250

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10.1038/NCOMMS3250

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4

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2013-01-01T00:00:00Z

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254267148

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1004553348

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23907271

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3905799

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