Stereochemical modification of geminal dialkyl substituents on pantothenamides alters antimicrobial activity

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A pantetheinase-resistant pantothenamide with potent, on-target, and selective antiplasmodial activity A cross-metathesis approach to novel pantothenamide derivatives.Triazole Substitution of a Labile Amide Bond Stabilizes Pantothenamides and Improves Their Antiplasmodial Potency.

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Stereochemical modification of geminal dialkyl substituents on pantothenamides alters antimicrobial activity

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article científic

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article scientifique

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artigo científico

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bilimsel makale

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scientific article published on 18 June 2014

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Stereochemical modification of ...... alters antimicrobial activity

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Stereochemical modification of ...... alters antimicrobial activity.

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Stereochemical modification of ...... alters antimicrobial activity

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Stereochemical modification of ...... alters antimicrobial activity.

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Stereochemical modification of ...... alters antimicrobial activity

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Stereochemical modification of ...... alters antimicrobial activity.

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Stereochemical modification of ...... alters antimicrobial activity

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Annabelle Hoegl

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Eleanor S C Kerdo

http://www.w3.org/2001/XMLSchema#string

Elisa Tran

http://www.w3.org/2001/XMLSchema#string

Emelia Awuah

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Hamed Darabi

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Karine Auclair

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P2860

From genetic footprinting to antimicrobial drug targets: examples in cofactor biosynthetic pathways

Inhibitors of pantothenate kinase: novel antibiotics for staphylococcal infections

Structural modification of pantothenamides counteracts degradation by pantetheinase and improves antiplasmodial activity

Antibacterial activity of N-pentylpantothenamide is due to inhibition of coenzyme a synthesis

Provitamin B5 (pantothenol) inhibits growth of the intraerythrocytic malaria parasite.

A class of pantothenic acid analogs inhibits Plasmodium falciparum pantothenate kinase and represses the proliferation of malaria parasites

Pantothenamides are potent, on-target inhibitors of Plasmodium falciparum growth when serum pantetheinase is inactivated

Geminal dialkyl derivatives of N-substituted pantothenamides: synthesis and antibacterial activity.

The fallacies of hope: will we discover new antibiotics to combat pathogenic bacteria in time?

Coenzyme A biosynthesis: an antimicrobial drug target.

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3274-3277

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scholarly article

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10.1016/J.BMCL.2014.06.013

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English

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P478

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Kevin J. Saliba

Eric Habib

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2014-06-18T00:00:00Z

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24986662

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5226837

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Stereochemical modification of geminal dialkyl substituents on pantothenamides alters antimicrobial activity

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P2860

P2860

Stereochemical modification of geminal dialkyl substituents on pantothenamides alters antimicrobial activity

description

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type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P932