Genomic regions of neurovirulence and attenuation in Theiler murine encephalomyelitis virus.
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Leader (L) and L* proteins of Theiler's murine encephalomyelitis virus (TMEV) and their regulation of the virus' biological activitiesTheiler's virus infection: a model for multiple sclerosisA coding RNA sequence acts as a replication signal in cardiovirusesThree-dimensional structure of Theiler murine encephalomyelitis virus (BeAn strain)Theiler's viruses with mutations in loop I of VP1 lead to altered tropism and pathogenesis.The neurovirulence of the DA and GDVII strains of Theiler's virus correlates with their ability To infect cultured neuronsSialylation of the host receptor may modulate entry of demyelinating persistent Theiler's virus.The leader polypeptide of Theiler's murine encephalomyelitis virus is required for the assembly of virions in mouse L cells.The leader protein of Theiler's virus inhibits immediate-early alpha/beta interferon production.A single base deletion in the 5' noncoding region of Theiler's virus attenuates neurovirulenceA spontaneous low-pathogenic variant of Theiler's virus contains an amino acid substitution within the predominant VP1(233-250) T-cell epitope.A determinant for central nervous system persistence localized in the capsid of Theiler's murine encephalomyelitis virus by using recombinant viruses.Mutations that affect the tropism of DA and GDVII strains of Theiler's virus in vitro influence sialic acid binding and pathogenicity.The leader polypeptide of Theiler's virus is essential for neurovirulence but not for virus growth in BHK cells.Role of VP2 amino acid 141 in tropism of Theiler's virus within the central nervous system.Neuropathogenicity of Two Saffold Virus Type 3 Isolates in Mouse Models.Epitope-specific CD8+ T cells play a differential pathogenic role in the development of a viral disease model for multiple sclerosisImportance of amino acid 101 within capsid protein VP1 for modulation of Theiler's virus-induced disease.Assembly of Theiler's virus recombinants used in mapping determinants of neurovirulence.Chimeric cDNA studies of Theiler's murine encephalomyelitis virus neurovirulence.Pathogenesis of early and late disease in mice infected with Theiler's virus, using intratypic recombinant GDVII/DA virusesDeterminants of persistence and demyelination of the DA strain of Theiler's virus are found only in the VP1 gene.cDNA clone of hepatitis A virus encoding a virulent virus: induction of viral hepatitis by direct nucleic acid transfection of marmosets.Genetic mapping of the ability of Theiler's virus to persist and demyelinate.The 5' noncoding sequences from a less virulent Theiler's virus dramatically attenuate GDVII neurovirulenceIntracerebral inoculation of mouse-passaged Saffold virus type 3 affects cerebellar development in neonatal mice.Infection of macrophage primary cultures by persistent and nonpersistent strains of Theiler's virus: role of capsid and noncapsid viral determinants.Saffold virus, a novel human Cardiovirus with unknown pathogenicity.Role of sialyloligosaccharide binding in Theiler's virus persistence.Analysis of cellular mutants resistant to Theiler's virus infection: differential infection of L929 cells by persistent and neurovirulent strains.Mutation of predicted virion pit residues alters binding of Theiler's murine encephalomyelitis virus to BHK-21 cells.Amino acid substitutions in VP2 residues contacting sialic acid in low-neurovirulence BeAn virus dramatically reduce viral binding and spread of infection.Identification of a major T-cell epitope within VP3 amino acid residues 24 to 37 of Theiler's virus in demyelination-susceptible SJL/J mice.Predominant binding of Theiler's viruses to a 34-kilodalton receptor protein on susceptible cell lines.Virus persistence in an animal model of multiple sclerosis requires virion attachment to sialic acid coreceptorsAnalysis of the molecular basis of neuropathogenesis of RNA viruses in experimental animals: relevance for human disease?Evaluation of an indirect enzyme-linked immunosorbent assay for routine screening of Theiler's murine encephalomyelitis virus antibodies in mice colonies.
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P2860
Genomic regions of neurovirulence and attenuation in Theiler murine encephalomyelitis virus.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on February 1990
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Genomic regions of neurovirule ...... urine encephalomyelitis virus.
@en
Genomic regions of neurovirule ...... urine encephalomyelitis virus.
@nl
type
label
Genomic regions of neurovirule ...... urine encephalomyelitis virus.
@en
Genomic regions of neurovirule ...... urine encephalomyelitis virus.
@nl
prefLabel
Genomic regions of neurovirule ...... urine encephalomyelitis virus.
@en
Genomic regions of neurovirule ...... urine encephalomyelitis virus.
@nl
P2093
P2860
P356
P1476
Genomic regions of neurovirule ...... urine encephalomyelitis virus.
@en
P2093
H L Lipton
K S Faaberg
M A Calenoff
P2860
P304
P356
10.1073/PNAS.87.3.978
P407
P577
1990-02-01T00:00:00Z