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The aryl hydrocarbon receptor has an important role in the regulation of hematopoiesis: implications for benzene-induced hematopoietic toxicityTranscription factor GATA-1 and Down syndrome leukemogenesisOncogenic pathways of AML1-ETO in acute myeloid leukemia: multifaceted manipulation of marrow maturation.The molecular basis of congenital thrombocytopenias: insights into megakaryopoiesis.Loss of the Gata1 gene IE exon leads to variant transcript expression and the production of a GATA1 protein lacking the N-terminal domainDynamic regulation of Gata1 expression during the maturation of conventional dendritic cells.Repression of c-kit and its downstream substrates by GATA-1 inhibits cell proliferation during erythroid maturationGATA-1 directly regulates p21 gene expression during erythroid differentiationConcise review: preleukemic stem cells: molecular biology and clinical implications of the precursors to leukemia stem cellsStat3 promotes the development of erythroleukemia by inducing Pu.1 expression and inhibiting erythroid differentiationGATA Transcription Factors and Cancer.Differential sensitivities of transcription factor target genes underlie cell type-specific gene expression profiles.The hypomorphic Gata1low mutation alters the proliferation/differentiation potential of the common megakaryocytic-erythroid progenitor.Effect of transcription-factor concentrations on leukemic stem cells.Early block to erythromegakaryocytic development conferred by loss of transcription factor GATA-1.Differential contribution of the Gata1 gene hematopoietic enhancer to erythroid differentiation.Loss of aryl hydrocarbon receptor promotes gene changes associated with premature hematopoietic stem cell exhaustion and development of a myeloproliferative disorder in aging mice.The role of PU.1 and GATA-1 transcription factors during normal and leukemogenic hematopoiesis.Unique clinical and biological features of leukemia in Down syndrome children.Contribution of GATA1 dysfunction to multi-step leukemogenesis.Stem cell origin of myelodysplastic syndromes.Evolution of myeloid leukemia in children with Down syndrome.GATA1 Activity Governed by Configurations of cis-Acting Elements.Establishment of erythroleukemic GAK14 cells and characterization of GATA1 N-terminal domain.Graded levels of GATA-1 expression modulate survival, proliferation, and differentiation of erythroid progenitors.Minimal PU.1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia.Phosphatidylinositol 3-kinase/Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation.GATA factor switching from GATA2 to GATA1 contributes to erythroid differentiation.GATA1 insufficiencies in primary myelofibrosis and other hematopoietic disorders: consequences for therapy.GATA-1 self-association controls erythroid development in vivo.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on December 2004
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Leukemogenesis caused by incapacitated GATA-1 function.
@en
Leukemogenesis caused by incapacitated GATA-1 function.
@nl
type
label
Leukemogenesis caused by incapacitated GATA-1 function.
@en
Leukemogenesis caused by incapacitated GATA-1 function.
@nl
prefLabel
Leukemogenesis caused by incapacitated GATA-1 function.
@en
Leukemogenesis caused by incapacitated GATA-1 function.
@nl
P2093
P2860
P1476
Leukemogenesis caused by incapacitated GATA-1 function.
@en
P2093
Kinuko Ohneda
Masayuki Yamamoto
Osamu Ohneda
Ritsuko Shimizu
Satoru Takahashi
Sjaak Philipsen
Takashi Kuroha
Xiaoqing Pan
P2860
P304
10814-10825
P356
10.1128/MCB.24.24.10814-10825.2004
P407
P577
2004-12-01T00:00:00Z