BRCA1 16 years later: nuclear import and export processes.
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The BRCA1 Breast Cancer Suppressor: Regulation of Transport, Dynamics, and Function at Multiple Subcellular LocationsCharacterization of Promiscuous Binding of Phosphor Ligands to Breast-Cancer-Gene 1 (BRCA1) C-Terminal (BRCT): Molecular Dynamics, Free Energy, Entropy and Inhibitor DesignHomologs of breast cancer genes in plantsTargeting nucleocytoplasmic transport in cancer therapyNucleo-cytoplasmic transport as a therapeutic target of cancerSystematic nucleo-cytoplasmic trafficking of proteins following exposure of MCF7 breast cancer cells to estradiol.Nuclear localization of the transcriptional regulator MIER1α requires interaction with HDAC1/2 in breast cancer cells.Biomarkers of histone deacetylase inhibitor activity in a phase 1 combined-modality study with radiotherapy.Role of the nuclear receptor coactivator AIB1-Delta4 splice variant in the control of gene transcription.Hypoxia elicits broad and systematic changes in protein subcellular localization.Exploiting the P-1 pocket of BRCT domains toward a structure guided inhibitor design.Inhibition of Stat5a/b Enhances Proteasomal Degradation of Androgen Receptor Liganded by Antiandrogens in Prostate Cancer.Nucleoporin NUP153 guards genome integrity by promoting nuclear import of 53BP1Ubc9 mediates nuclear localization and growth suppression of BRCA1 and BRCA1a proteinsAssociation between cytosolic expression of BRCA1 and metastatic risk in breast cancer.BRCA1 proteins regulate growth of ovarian cancer cells by tethering Ubc9RCC1-dependent activation of Ran accelerates cell cycle and DNA repair, inhibiting DNA damage-induced cell senescence.Targeting BRCA1 localization to augment breast tumor sensitivity to poly(ADP-Ribose) polymerase inhibition.BRCA1 16 years later: risk-associated BRCA1 mutations and their functional implications.BRCA1 16 years later: DNA damage-induced BRCA1 shuttling.Proteomics reveals the importance of the dynamic redistribution of the subcellular location of proteins in breast cancer cells.Design Principles Involving Protein Disorder Facilitate Specific Substrate Selection and Degradation by the Ubiquitin-Proteasome System.hCAS/CSE1L regulates RAD51 distribution and focus formation for homologous recombinational repair.Enzalutamide, an androgen receptor signaling inhibitor, induces tumor regression in a mouse model of castration-resistant prostate cancer.Discovery of cell-permeable inhibitors that target the BRCT domain of BRCA1 protein by using a small-molecule microarray.O-GlcNAc cycling and the regulation of nucleocytoplasmic dynamics.Targeting endogenous nuclear antigens by electrotransfer of monoclonal antibodies in living cells.The identification of a novel role for BRCA1 in regulating RNA polymerase I transcription.Impact of Etoposide on BRCA1 Expression in Various Breast Cancer Cell Lines.A cross-sectional study of associations between nonsynonymous mutations of the BARD1 gene and breast cancer in Han Chinese women.Induced Cre-mediated knockdown of Brca1 in skeletal muscle reduces mitochondrial respiration and prevents glucose intolerance in adult mice on a high-fat diet.Protein-Protein Interaction Inhibitors of BRCA1 Discovered Using Small Molecule Microarrays.Expression of proteins involved in DNA damage response in familial and sporadic breast cancer patients.
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BRCA1 16 years later: nuclear import and export processes.
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article científic
@ca
article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on July 2010
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
BRCA1 16 years later: nuclear import and export processes.
@en
BRCA1 16 years later: nuclear import and export processes.
@nl
type
label
BRCA1 16 years later: nuclear import and export processes.
@en
BRCA1 16 years later: nuclear import and export processes.
@nl
prefLabel
BRCA1 16 years later: nuclear import and export processes.
@en
BRCA1 16 years later: nuclear import and export processes.
@nl
P2860
P1433
P1476
BRCA1 16 years later: nuclear import and export processes.
@en
P2093
Marilyn E Thompson
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P304
P356
10.1111/J.1742-4658.2010.07733.X
P407
P577
2010-07-01T00:00:00Z