Werner syndrome protein suppresses the formation of large deletions during the replication of human telomeric sequences.
about
G-quadruplexes and helicasesTelomere shortening in human diseasesWerner syndrome: Clinical features, pathogenesis and potential therapeutic interventionsIdentification and characterization of SMARCAL1 protein complexesSingle-molecule imaging reveals a common mechanism shared by G-quadruplex-resolving helicasesWRN regulates pathway choice between classical and alternative non-homologous end joiningThe Werner syndrome protein limits the error-prone 8-oxo-dG lesion bypass activity of human DNA polymerase kappa.G4-associated human diseases.Human RecQ helicases in DNA repair, recombination, and replication.RECQ helicases are deregulated in hematological malignancies in association with a prognostic valueAtrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span.Polymorphisms in DNA repair genes, hair dye use, and the risk of non-Hodgkin lymphomaMTOR-driven quasi-programmed aging as a disposable soma theory: blind watchmaker vs. intelligent designer.The Werner syndrome RECQ helicase targets G4 DNA in human cells to modulate transcription.Targeting an Achilles' heel of cancer with a WRN helicase inhibitorIntramolecular telomeric G-quadruplexes dramatically inhibit DNA synthesis by replicative and translesion polymerases, revealing their potential to lead to genetic change.G-quadruplex interacting small molecules and drugs: from bench toward bedside.Human Rev1 polymerase disrupts G-quadruplex DNA.A hidden role of the inactivated FANCD2: upregulating ΔNp63.Yeast Hrq1 shares structural and functional homology with the disease-linked human RecQ4 helicase.Recent Advances in Understanding Werner Syndrome.Residues in the RecQ C-terminal Domain of the Human Werner Syndrome Helicase Are Involved in Unwinding G-quadruplex DNA.The Hrq1 and Pif1 DNA helicases synergistically modulate telomerase activity
P2860
Q26765428-7CB6083E-42F8-48FF-8ED7-CF145CCE5D9AQ27004080-7F03BC02-6BA9-496F-8871-5BDC48BD63BEQ28274227-3ECDDD9C-C05B-4E7F-B85D-54A12BE001FAQ28487879-E7B3CCDB-08F7-4A90-A812-8F015A15CB28Q28828293-C2008B05-0279-4AF0-873C-9B2122F0E2D1Q30831557-112165D2-5020-40E3-9129-6FF6F3DE754FQ34510161-E4A1F4C9-A197-4FEF-83F1-EF6F466857F6Q36004245-D5D3CD6F-70ED-415A-A88A-D3CDBDDB9B6AQ36101160-E89957F8-B895-4C4F-8693-070D12E0D28AQ36577713-483E96CA-DC3B-4375-BEB1-71276EF2C8B4Q36793436-26D2A2DF-BDD4-4875-BA9A-95201437FBBFQ36832372-5E55B8D4-5135-4B09-8951-4D2C3350B681Q37075896-880A3985-79D9-4BD4-97B4-5D9CEEB6F1ACQ37336151-D88EAC86-0138-47FE-909F-0279F1FF058EQ37452985-51C92932-724C-4991-A1DD-39466669D8E2Q37477870-1C457A24-A90E-4BEA-A9FA-199EFEA55DD6Q38236665-3DDBEE13-1E5E-4D8C-98C3-EDA1BB499048Q38256960-179CF127-A7C8-45B5-8079-FA2816D7D05AQ39107105-EEDB5F88-B60A-457B-8DC6-89B606F3D0A8Q41693967-718C52A3-771A-4709-8DB2-504F11950CF2Q42367242-C8811A9C-8F03-4261-B0FC-B6C95DD3C767Q51204003-43D1397C-33B8-42E3-BBAF-DD614A2AB8BFQ57752983-926105B3-9A3D-40BA-934B-8AA71CA56468
P2860
Werner syndrome protein suppresses the formation of large deletions during the replication of human telomeric sequences.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Werner syndrome protein suppre ...... of human telomeric sequences.
@en
Werner syndrome protein suppre ...... of human telomeric sequences.
@nl
type
label
Werner syndrome protein suppre ...... of human telomeric sequences.
@en
Werner syndrome protein suppre ...... of human telomeric sequences.
@nl
prefLabel
Werner syndrome protein suppre ...... of human telomeric sequences.
@en
Werner syndrome protein suppre ...... of human telomeric sequences.
@nl
P2093
P2860
P50
P356
P1433
P1476
Werner syndrome protein suppre ...... of human telomeric sequences.
@en
P2093
Fu-Jun Liu
Steven Strutt
P2860
P304
P356
10.4161/CC.21399
P577
2012-08-08T00:00:00Z