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The emerging role of histone lysine demethylases in prostate cancerOxidative stress and epigenetic regulation in ageing and age-related diseasesBiochemical, structural, and biological evaluation of tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and LSD2An Analog of BIX-01294 Selectively Inhibits a Family of Histone H3 Lysine 9 Jumonji DemethylasesProtein recognition by short peptide reversible inhibitors of the chromatin-modifying LSD1/CoREST lysine demethylaseSynthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: a novel class of irreversible inhibitors of histone demethylase KDM1APyrrylphenylethanones related to cathinone and lefetamine: synthesis and pharmacological activitiesNitroquinolones with broad-spectrum antimycobacterial activity in vitro5-Alkyl-2-(alkylthio)-6-(2,6-dihalophenylmethyl)-3, 4-dihydropyrimidin-4(3H)-ones: novel potent and selective dihydro-alkoxy-benzyl-oxopyrimidine derivativesEvaluation of histone deacetylases as drug targets in Huntington's disease models. Study of HDACs in brain tissues from R6/2 and CAG140 knock-in HD mouse models and human patients and in a neuronal HD cell modelProperly substituted analogues of BIX-01294 lose inhibition of G9a histone methyltransferase and gain selective anti-DNA methyltransferase 3A activity.Targeting Lysine Deacetylases (KDACs) in ParasitesP300/CBP associated factor regulates nitroglycerin-dependent arterial relaxation by N(ε)-lysine acetylation of contractile proteinsStructural Basis of Sirtuin 6 Activation by Synthetic Small Molecules."Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence.Discovery of uracil-based histone deacetylase inhibitors able to reduce acquired antifungal resistance and trailing growth in Candida albicans.Small molecule inhibitors of histone arginine methyltransferases: homology modeling, molecular docking, binding mode analysis, and biological evaluations.Pharmacological inhibition of EZH2 as a promising differentiation therapy in embryonal RMSSpecific activity of class II histone deacetylases in human breast cancer cellsPRMT1 arginine methyltransferase accumulates in cytoplasmic bodies that respond to selective inhibition and DNA damageA photoreactive small-molecule probe for 2-oxoglutarate oxygenases.Identification of small-molecule inhibitors of the XendoU endoribonucleases family.Sirtinol treatment reduces inflammation in human dermal microvascular endothelial cellsTNF/p38α/polycomb signaling to Pax7 locus in satellite cells links inflammation to the epigenetic control of muscle regeneration.Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities.Identification of small-molecule enhancers of arginine methylation catalyzed by coactivator-associated arginine methyltransferase 1.Class II HDAC inhibition hampers hepatic stellate cell activation by induction of microRNA-29Nε-lysine acetylation determines dissociation from GAP junctions and lateralization of connexin 43 in normal and dystrophic heart.Screen of pseudopeptidic inhibitors of human sirtuins 1-3: two lead compounds with antiproliferative effects in cancer cells.Synthesis and biological evaluation of enantiomerically pure pyrrolyl-oxazolidinones as a new class of potent and selective monoamine oxidase type A inhibitors.Pure Diastereomers of a Tranylcypromine-Based LSD1 Inhibitor: Enzyme Selectivity and In-Cell Studies.HDAC4-regulated STAT1 activation mediates platinum resistance in ovarian cancer.Interplay among nucleosomal DNA, histone tails, and corepressor CoREST underlies LSD1-mediated H3 demethylation.Evaluation of a large library of (thiazol-2-yl)hydrazones and analogues as histone acetyltransferase inhibitors: enzyme and cellular studies.Specific control of pancreatic endocrine β- and δ-cell mass by class IIa histone deacetylases HDAC4, HDAC5, and HDAC9Quinoline derivative MC1626, a putative GCN5 histone acetyltransferase (HAT) inhibitor, exhibits HAT-independent activity against Toxoplasma gondii.SIRT5 regulation of ammonia-induced autophagy and mitophagy.Histone deacetylation in epigenetics: an attractive target for anticancer therapy.Amino acid starvation induces reactivation of silenced transgenes and latent HIV-1 provirus via down-regulation of histone deacetylase 4 (HDAC4)p300/CBP-associated factor selectively regulates the extinction of conditioned fear.
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Antonello Mai
@ast
Antonello Mai
@en
Antonello Mai
@es
Antonello Mai
@nl
type
label
Antonello Mai
@ast
Antonello Mai
@en
Antonello Mai
@es
Antonello Mai
@nl
prefLabel
Antonello Mai
@ast
Antonello Mai
@en
Antonello Mai
@es
Antonello Mai
@nl
P106
P1153
7005565428
P21
P31
P496
0000-0001-9176-2382