Essential role of the B23/NPM core domain in regulating ARF binding and B23 stability.
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NPM1/B23: A Multifunctional Chaperone in Ribosome Biogenesis and Chromatin RemodelingRibosomal protein S9 is a novel B23/NPM-binding protein required for normal cell proliferationCancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradationStructural polymorphism in the N-terminal oligomerization domain of NPM1GLTSCR2 is an upstream negative regulator of nucleophosmin in cervical cancer.The nuclear chaperone nucleophosmin escorts an Epstein-Barr Virus nuclear antigen to establish transcriptional cascades for latent infection in human B cellsAKT regulates NPM dependent ARF localization and p53mut stability in tumors.Elucidation of motifs in ribosomal protein S9 that mediate its nucleolar localization and binding to NPM1/nucleophosminLoss of nucleolar histone chaperone NPM1 triggers rearrangement of heterochromatin and synergizes with a deficiency in DNA methyltransferase DNMT3A to drive ribosomal DNA transcription.Sumoylation of nucleophosmin/B23 regulates its subcellular localization, mediating cell proliferation and survival.Mitochondrial p32 is a critical mediator of ARF-induced apoptosisDynamic Protein Interaction Networks and New Structural Paradigms in Signaling.Expression of nucleophosmin/NPM1 correlates with migration and invasiveness of colon cancer cells.Localization of AML-related nucleophosmin mutant depends on its subtype and is highly affected by its interaction with wild-type NPMNucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA.Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination.The promiscuity of ARF interactions with the proteasome.Deregulated expression of Nucleophosmin 1 in gastric cancer and its clinicopathological implications.PI3K/Akt-mediated regulation of p53 in cancer.Asymmetric Modulation of Protein Order-Disorder Transitions by Phosphorylation and Partner Binding.Mutation of cysteine 21 inhibits nucleophosmin/B23 oligomerization and chaperone activityNPM1 histone chaperone is upregulated in glioblastoma to promote cell survival and maintain nucleolar shape.RNA helicase DDX5 is a p53-independent target of ARF that participates in ribosome biogenesis.Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer.Estrogen stimulates the proliferation of human endometrial cancer cells by stabilizing nucleophosmin/B23 (NPM/B23).Hepatocyte odd protein shuttling (HOPS) is a bridging protein in the nucleophosmin-p19 Arf network.Binding to nucleophosmin determines the localization of human and chicken ARF but not its impact on p53.Guanine nucleotide depletion inhibits pre-ribosomal RNA synthesis and causes nucleolar disruption.Release the ink4a/arf growth suppression by "u" and "me"?Lysine 263 residue of NPM/B23 is essential for regulating ATP binding and B23 stability.Analysis of the oligomeric states of nucleophosmin using size exclusion chromatography.
P2860
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P2860
Essential role of the B23/NPM core domain in regulating ARF binding and B23 stability.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Essential role of the B23/NPM core domain in regulating ARF binding and B23 stability.
@en
type
label
Essential role of the B23/NPM core domain in regulating ARF binding and B23 stability.
@en
prefLabel
Essential role of the B23/NPM core domain in regulating ARF binding and B23 stability.
@en
P2093
P2860
P356
P1476
Essential role of the B23/NPM core domain in regulating ARF binding and B23 stability.
@en
P2093
Mikael S Lindström
Takeharu Enomoto
Yanping Zhang
P2860
P304
18463-18472
P356
10.1074/JBC.M602788200
P407
P50
P577
2006-05-05T00:00:00Z