Phosphorylation of threonine 290 in the activation loop of Tpl2/Cot is necessary but not sufficient for kinase activity.
about
Plant and animal pathogen recognition receptors signal through non-RD kinasesTranslocation of human ribosomal protein S3 to sites of DNA damage is dependant on ERK-mediated phosphorylation following genotoxic stressTumor progression locus 2 (Tpl2) kinase as a novel therapeutic target for cancer: double-sided effects of Tpl2 on cancerChromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomesEvidence that phosphorylation of threonine in the GT motif triggers activation of PknA, a eukaryotic-type serine/threonine kinase from Mycobacterium tuberculosisRegulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinaseRegulation of mixed-lineage kinase activation in JNK-dependent morphogenesis.Phosphorylation at Thr-290 regulates Tpl2 binding to NF-kappaB1/p105 and Tpl2 activation and degradation by lipopolysaccharide.Macrophages in multiple myeloma: emerging concepts and therapeutic implications.Inhibition of Cot1/Tlp2 oncogene in AML cells reduces ERK5 activation and up-regulates p27Kip1 concomitant with enhancement of differentiation and cell cycle arrest induced by silibinin and 1,25-dihydroxyvitamin D(3).Pharmacological inhibition of TPL2/MAP3K8 blocks human cytotoxic T lymphocyte effector functions.Phosphorylation of TPL-2 on serine 400 is essential for lipopolysaccharide activation of extracellular signal-regulated kinase in macrophages.A comprehensive map of the toll-like receptor signaling network.IκB kinase regulation of the TPL-2/ERK MAPK pathway.Cancer Osaka thyroid (Cot) phosphorylates Polo-like kinase (PLK1) at Ser137 but not at Thr210.IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2.Interleukin 1/Toll-like receptor-induced autophosphorylation activates interleukin 1 receptor-associated kinase 4 and controls cytokine induction in a cell type-specific mannerA TPL2 (MAP3K8) disease-risk polymorphism increases TPL2 expression thereby leading to increased pattern recognition receptor-initiated caspase-1 and caspase-8 activation, signalling and cytokine secretion.Tpl2 (tumor progression locus 2) phosphorylation at Thr290 is induced by lipopolysaccharide via an Ikappa-B Kinase-beta-dependent pathway and is required for Tpl2 activation by external signals.Assaying kinase activity of the TPL-2/NF-κB1 p105/ABIN-2 complex using an optimal peptide substrate.Interleukin-1 stimulated activation of the COT catalytic subunit through the phosphorylation of Thr290 and Ser62.Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood.Autophosphorylation Mechanism of the Ser/Thr Kinase Stk1 From Staphylococcus aureus.Mechanism of dysfunction of human variants of the IRAK4 kinase and a role for its kinase activity in interleukin-1 receptor signalingA Single Amino Acid Substitution in the Renal Betaine/GABA Transporter Prevents Trafficking to the Plasma Membrane
P2860
Q21131622-2EA07AB0-C84E-4575-81F5-ADFA98D0D2BBQ24309217-E447AD18-C448-4F2E-A79F-3192E8D35780Q27021391-9728215C-B517-44F3-90CC-EBAA5ADE2EFBQ27301063-91FD615A-2FD9-41A0-B437-3CC13477E2B1Q27697968-4CCF9661-82FC-42BD-BAA2-BDB525D39BC8Q28392677-A2D36179-08B1-4559-8D39-C475496D57BCQ30156053-B77751A6-8405-4564-AB1B-308BA631255DQ33850120-68B0D68F-66F1-4BEB-8B33-60D4DCF2E91DQ34329242-4DF2F52A-4A93-42BD-BD68-2DC77CA2A9A6Q34620898-D134F1F5-3660-418C-8F80-0321E633BE18Q35124167-397A5F2A-502B-4135-88FF-DE8855DE1BE9Q36315622-22081DE0-7FF1-42ED-B1B8-CBDA1DAB9FD6Q36494115-910EF84D-AD38-446E-A26C-637BFB780A32Q37995683-F1BF97C4-B63C-44C3-B0EA-66078336008CQ39791482-51C564E0-99D6-41D5-AC69-16314D599D8CQ39799629-5FDEB854-254D-4070-94FF-DFA5A118A584Q40002165-9EA0E020-8A26-4643-A25D-AB57799E28AFQ42741761-37D38253-EA86-47B6-B3B5-5034E2EFFA2DQ46390923-8C98C719-68B2-4CDE-AABA-82C8B0AEF50AQ49920636-6C2A8763-59B7-40E5-BC76-C6872FF0BC87Q50335837-3D7E5CB0-A214-4CE0-A8EA-07702F4761AFQ50665953-017DA5ED-CFD3-4040-A270-B0768679669CQ53687214-6E638335-DD78-4532-9FE5-C034B08634D7Q57059334-D388DFC3-F58C-4E81-99F7-AE673C90D59EQ58919899-181ABE8B-DE49-4E5E-8B28-41CC9E8C7092
P2860
Phosphorylation of threonine 290 in the activation loop of Tpl2/Cot is necessary but not sufficient for kinase activity.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Phosphorylation of threonine 2 ...... ufficient for kinase activity.
@en
type
label
Phosphorylation of threonine 2 ...... ufficient for kinase activity.
@en
prefLabel
Phosphorylation of threonine 2 ...... ufficient for kinase activity.
@en
P2093
P2860
P356
P1476
Phosphorylation of threonine 2 ...... ufficient for kinase activity.
@en
P2093
Brenda S Luciano
John W Cuozzo
Lih-Ling Lin
Padma L Channavajhala
P2860
P304
52117-52123
P356
10.1074/JBC.M403716200
P407
P577
2004-10-04T00:00:00Z