Overactivation of phospholipase C-gamma1 renders platelet-derived growth factor beta-receptor-expressing cells independent of the phosphatidylinositol 3-kinase pathway for chemotaxis.
about
Site-selective dephosphorylation of the platelet-derived growth factor beta-receptor by the receptor-like protein-tyrosine phosphatase DEP-1Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphataseSpontaneous phosphoinositide 3-kinase signaling dynamics drive spreading and random migration of fibroblastsConstitutive macropinocytosis in oncogene-transformed fibroblasts depends on sequential permanent activation of phosphoinositide 3-kinase and phospholipase C.Mechanisms of platelet-derived growth factor-induced chemotaxis.Activity of PLCε contributes to chemotaxis of fibroblasts towards PDGFPDGF-BB enhances collagen gel contraction through a PI3K-PLCγ-PKC-cofilin pathwayInvolvement of CD9 and PDGFR in migration is evolutionarily conserved from Drosophila glia to human glioma.Role of phospholipase Cgamma1 in cell spreading requires association with a beta-Pix/GIT1-containing complex, leading to activation of Cdc42 and Rac1.Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor.Chemokine-independent preference for T-helper-1 cells in transendothelial migration.Activation of protein kinase C alpha is necessary for sorting the PDGF beta-receptor to Rab4a-dependent recycling.The MMAC1 tumor suppressor phosphatase inhibits phospholipase C and integrin-linked kinase activity.Platelet-derived growth factor-induced Akt phosphorylation requires mTOR/Rictor and phospholipase C-γ1, whereas S6 phosphorylation depends on mTOR/Raptor and phospholipase DMacrophage/microglia-specific protein Iba1 enhances membrane ruffling and Rac activation via phospholipase C-gamma -dependent pathway.Gab1 contributes to cytoskeletal reorganization and chemotaxis in response to platelet-derived growth factor.
P2860
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P2860
Overactivation of phospholipase C-gamma1 renders platelet-derived growth factor beta-receptor-expressing cells independent of the phosphatidylinositol 3-kinase pathway for chemotaxis.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Overactivation of phospholipas ...... kinase pathway for chemotaxis.
@en
type
label
Overactivation of phospholipas ...... kinase pathway for chemotaxis.
@en
prefLabel
Overactivation of phospholipas ...... kinase pathway for chemotaxis.
@en
P2093
P2860
P356
P1476
Overactivation of phospholipas ...... -kinase pathway for chemotaxis
@en
P2093
P2860
P304
22089-22094
P356
10.1074/JBC.274.31.22089
P407
P577
1999-07-01T00:00:00Z