Enhancement of glycine receptor function by ethanol is inversely correlated with molecular volume at position alpha267.
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General anaesthetic actions on ligand-gated ion channelsStructure of a specific alcohol-binding site defined by the odorant binding protein LUSH from Drosophila melanogasterOpen-channel structures of the human glycine receptor α1 full-length transmembrane domain.Methionine 286 in transmembrane domain 3 of the GABAA receptor beta subunit controls a binding cavity for propofol and other alkylphenol general anestheticsPositive allosteric modulation by ivermectin of human but not murine P2X7 receptorsEthanol effects on glycinergic transmission: From molecular pharmacology to behavior responsesMolecular requirements for ethanol differential allosteric modulation of glycine receptors based on selective Gbetagamma modulation.Propofol binding to the resting state of the gloeobacter violaceus ligand-gated ion channel (GLIC) induces structural changes in the inter- and intrasubunit transmembrane domain (TMD) cavitiesAllosteric modulation of glycine receptors.Direct evidence for a cause-effect link between ethanol potentiation of GABA(A) receptor function and intoxication from hyperbaric studies in C57, LS, and SS mice.Ethanol potentiation of glycine receptors expressed in Xenopus oocytes antagonized by increased atmospheric pressure.Targets for ethanol action and antagonism in loop 2 of the extracellular domain of glycine receptors.A point mutation in the ectodomain-transmembrane 2 interface eliminates the inhibitory effects of ethanol in P2X4 receptors.The role of GABA(A) receptors in the acute and chronic effects of ethanol: a decade of progressEthanol and protein kinase C.Ethanol actions on multiple ion channels: which are important?Molecular targets and mechanisms for ethanol action in glycine receptorsA transmembrane amino acid in the GABAA receptor β2 subunit critical for the actions of alcohols and anesthetics.Specific binding sites for alcohols and anesthetics on ligand-gated ion channels.Acetylcholine and alcohol sensitivity of neuronal nicotinic acetylcholine receptors: mutations in transmembrane domains.Microsecond simulations indicate that ethanol binds between subunits and could stabilize an open-state model of a glycine receptor.Agonist activation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane sitePotentiation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site.Two alcohol binding residues interact across a domain interface of the L1 neural cell adhesion molecule and regulate cell adhesion.Mode of action of ICS 205,930, a novel type of potentiator of responses to glycine in rat spinal neurones.Subunit mutations affect ethanol actions on GABA(A) receptors expressed in Xenopus oocytes.Tryptophan scanning mutagenesis in TM2 of the GABA(A) receptor alpha subunit: effects on channel gating and regulation by ethanol.Mutations of L293 in transmembrane two of the mouse 5-hydroxytryptamine3A receptor alter gating and alcohol modulatory actionsThe role of GABAA receptors in mediating the effects of alcohol in the central nervous system.Positive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: advantages and limitations.Control of ethanol sensitivity of the glycine receptor α3 subunit by transmembrane 2, the intracellular splice cassette and C-terminal domains.Activated G protein α s subunits increase the ethanol sensitivity of human glycine receptorsThe basic property of Lys385 is important for potentiation of the human α1 glycine receptor by ethanol.Mutations at F637 in the NMDA receptor NR2A subunit M3 domain influence agonist potency, ion channel gating and alcohol actionPositive allosteric modulators differentially affect full versus partial agonist activation of the glycine receptorA selective G betagamma-linked intracellular mechanism for modulation of a ligand-gated ion channel by ethanol.Ethanol's molecular targetsA novel alcohol-sensitive position in the N-methyl-D-aspartate receptor GluN2A subunit M3 domain regulates agonist affinity and ion channel gating.Acute alcohol action and desensitization of ligand-gated ion channels.Differential actions of ethanol and trichloroethanol at sites in the M3 and M4 domains of the NMDA receptor GluN2A (NR2A) subunit.
P2860
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P2860
Enhancement of glycine receptor function by ethanol is inversely correlated with molecular volume at position alpha267.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
Enhancement of glycine recepto ...... r volume at position alpha267.
@en
type
label
Enhancement of glycine recepto ...... r volume at position alpha267.
@en
prefLabel
Enhancement of glycine recepto ...... r volume at position alpha267.
@en
P2093
P2860
P356
P1476
Enhancement of glycine recepto ...... r volume at position alpha267.
@en
P2093
Harrison NL
Koltchine VV
P2860
P304
P356
10.1074/JBC.273.6.3314
P407
P577
1998-02-01T00:00:00Z