Two different replication factor C proteins, Ctf18 and RFC1, separately control PCNA-CRL4Cdt2-mediated Cdt1 proteolysis during S phase and following UV irradiation.
about
Checkpoint kinase ATR phosphorylates Cdt2, a substrate receptor of CRL4 ubiquitin ligase, and promotes the degradation of Cdt1 following UV irradiation.Mitotic UV irradiation induces a DNA replication-licensing defect that potentiates G1 arrest response.Mismatch repair proteins recruited to ultraviolet light-damaged sites lead to degradation of licensing factor Cdt1 in the G1 phase.PIP degron proteins, substrates of CRL4Cdt2, and not PIP boxes, interfere with DNA polymerase η and κ focus formation on UV damageFlipping the switch from g1 to s phase with e3 ubiquitin ligasesThymine DNA glycosylase modulates DNA damage response and gene expression by base excision repair-dependent and independent mechanisms.Translesion Synthesis: Insights into the Selection and Switching of DNA Polymerases.Control of Genome Integrity by RFC Complexes; Conductors of PCNA Loading onto and Unloading from Chromatin during DNA Replication.Alternative replication factor C protein, Elg1, maintains chromosome stability by regulating PCNA levels on chromatin.Human CTF18-RFC clamp-loader complexed with non-synthesising DNA polymerase ε efficiently loads the PCNA sliding clamp.Mismatch repair regulates Cdt1 after UV damage.
P2860
Q34431295-BF593799-305F-4831-AB93-99A4BE1F4887Q35583775-05A5D9ED-1303-4429-BC70-8200298082AEQ36302154-041B85C7-A19D-4D98-B91C-1DCC7FD752F5Q37680370-FE0BECB6-E764-4C03-A03E-1D27CE2ADF18Q38103251-1C016F6A-4577-4122-83EE-6B305F394AD2Q38711581-BD1C3560-A012-4F1D-A65F-85B4AF9ED131Q39079498-43A81771-475B-4F05-91B7-28F9FC03266BQ39109267-28EE193C-CDC0-4A68-A5DD-6AC5B0565A28Q39111462-C79FAD13-DAF2-4486-BC4B-B6C46A02A897Q40335075-D221CE95-98C6-43DD-A7EC-EADA8C49CDD8Q52775937-9F9C4FB0-86C6-4594-82CA-B38F98FE5A64
P2860
Two different replication factor C proteins, Ctf18 and RFC1, separately control PCNA-CRL4Cdt2-mediated Cdt1 proteolysis during S phase and following UV irradiation.
description
2012 nî lūn-bûn
@nan
2012年の論文
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2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
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2012年學術文章
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name
Two different replication fact ...... and following UV irradiation.
@en
Two different replication fact ...... and following UV irradiation.
@nl
type
label
Two different replication fact ...... and following UV irradiation.
@en
Two different replication fact ...... and following UV irradiation.
@nl
prefLabel
Two different replication fact ...... and following UV irradiation.
@en
Two different replication fact ...... and following UV irradiation.
@nl
P2093
P2860
P50
P356
P1476
Two different replication fact ...... e and following UV irradiation
@en
P2093
Kaori Shinmyozu
Kaoru Sugasawa
Takashi Ishii
Yasushi Shiomi
P2860
P304
P356
10.1128/MCB.06506-11
P407
P577
2012-04-09T00:00:00Z